A5035688709- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Schizophrenia research and treatment
- Treatment of Major Depression
- Spatial Neglect and Hemispheric Dysfunction
- Advanced MRI Techniques and Applications
- Visual perception and processing mechanisms
- Neuroscience and Music Perception
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Health, Environment, Cognitive Aging
- Receptor Mechanisms and Signaling
- EEG and Brain-Computer Interfaces
- Bipolar Disorder and Treatment
- Pharmaceutical studies and practices
- Migraine and Headache Studies
- Creativity in Education and Neuroscience
- Medical Imaging Techniques and Applications
- Cognitive Science and Mapping
Centre Hospitalier Le Vinatier
2016-2025
Inserm
2014-2025
Centre National de la Recherche Scientifique
2014-2025
Université Claude Bernard Lyon 1
2014-2025
Centre de Recherche en Neurosciences de Lyon
2014-2025
Yale University
2020-2024
Connecticut Mental Health Center
2024
A single transcranial direct current stimulation (tDCS) session applied over the dorsolateral prefrontal cortex (DLFPC) can be associated with procognitive effects. Furthermore, repeated DLPFC tDCS sessions are under investigation as a new therapeutic tool for range of neuropsychiatric conditions. possible mechanism explaining such beneficial effects is modulation meso-cortico-limbic dopamine transmission. We explored spatial and temporal neurobiological bifrontal on subcortical transmission...
Abstract This article describes the rationale, aims, and methodology of Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). is largest international collaboration to date that will develop algorithms predict trajectories outcomes individuals at clinical high risk (CHR) for psychosis advance development use novel pharmacological interventions CHR individuals. We present a description participating research networks data processing analysis coordination center, their processes...
Introduction Neuroimaging technology has experienced explosive growth and transformed the study of neural mechanisms across health disease. However, given diversity sophisticated tools for handling neuroimaging data, field faces challenges in method integration, particularly multiple modalities species. Specifically, researchers often have to rely on siloed approaches which limit reproducibility, with idiosyncratic data organization limited software interoperability. Methods To address these...
Background: Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it unclear how ketamine’s molecular mechanisms connect its neural behavioral effects. Methods: We conducted a single-blind placebo-controlled study, with participants blinded their treatment condition. 40 healthy received acute (initial bolus 0.23 mg/kg, continuous infusion 0.58 mg/kg/hr)....
Auditory verbal hallucinations (AVH) of schizophrenia are associated with a disrupted connectivity between frontal and temporoparietal language areas. We hypothesized that this dysconnectivity is underpinned by white matter abnormalities in the left arcuate fasciculus, main fiber bundle connecting speech production perception therefore investigated relationship AVH severity integrity fasciculus measured diffusion tensor imaging (DTI) tractography patients schizophrenia. Thirty-eight...
Difficulties in advancing effective patient-specific therapies for psychiatric disorders highlight a need to develop stable neurobiologically grounded mapping between neural and symptom variation. This gap is particularly acute psychosis-spectrum (PSD). Here, sample of 436 PSD patients spanning several diagnoses, we derived replicated dimensionality-reduced space across hallmark psychopathology symptoms cognitive deficits. In turn, these axes mapped onto distinct, reproducible brain maps....
Abstract Decades of research have highlighted the importance optimal stimulation cortical dopaminergic receptors, particularly D1R receptor (D1R), for prefrontal-mediated cognition. This mechanism is relevant to cognitive deficits in schizophrenia, given abnormalities dopamine (DA) neurotransmission and expression D1R. Despite critical need D1R-based therapeutics, many factors complicated their development prevented this important therapeutic target from being adequately interrogated....
Each cortical area has a distinct pattern of anatomical connections within the thalamus, central subcortical structure composed functionally and structurally nuclei. Previous studies have suggested that certain areas may more extensive target multiple thalamic nuclei, which potentially allows them to modulate distributed information flow. However, there is lack quantitative investigations into connectivity patterns thalamus. Consequently, it remains unknown if exhibit systematic differences...
Deficits in working memory (WM) are a hallmark of neuropsychiatric disorders such as schizophrenia, yet their neurobiological basis remains poorly understood. Glutamate N-methyl-D-aspartate receptors (NMDARs) critical for spatial WM (sWM), with NMDAR antagonist ketamine known to attenuate task-evoked activation and reduce sWM accuracy. Cortical microcircuit models hypothesize that antagonism impairs by broadening neural tuning, but this mechanism has not been directly tested humans. Using...
Despite decades of research, cognitive impairment remains a critical untreated symptom for many patients with schizophrenia. One way to accelerate the development pro-cognitive therapies schizophrenia is evaluate compounds using biomarker approaches tailored relevant neural mechanisms. While D1/D5 receptor (D1R/D5R) agonism has been extensively studied in neuroscience, its therapeutic potential untapped. The Translational Neuroscience & Computational Evaluation D1R Partial Agonist...
Abstract Auditory verbal hallucinations (AVH) in patients with schizophrenia are linked to abnormalities within a large cerebral network including frontal and temporal regions. Whilst of speech production perception regions have been extensively studied, alterations the dorsolateral prefrontal cortex (DLPFC), region critically involved pathophysiology schizophrenia, rarely studied relation AVH. Using 1.5 T proton magnetic resonance spectroscopy, this study examined relationship between right...
Neural activity and behavior vary within an individual (states) between individuals (traits). However, the mapping of state-trait neural variation to is not well understood. To address this gap, we quantify moment-to-moment changes in brain-wide co-activation patterns derived from resting-state functional magnetic resonance imaging. In healthy young adults, identify reproducible spatio-temporal features at single subject level. We demonstrate that a joint analysis variations feature...
Neuroimaging technology has experienced explosive growth and transformed the study of neural mechanisms across health disease. However, given diversity sophisticated tools for handling neuroimaging data, field faces challenges in method integration (1–3), particularly multiple modalities species. Specifically, researchers often have to rely on siloed approaches which limit reproducibility, with idiosyncratic data organization limited software interoperability. To address these challenges, we...
This paper proposes an innovative method, named b-ntPET, for solving a competition model in PET. The is built upon the state-of-the-art method called lp-ntPET. It consists identifying parameters of PET kinetic relative to reference region that rule steady state exchanges, together with identification four additional defining displacement curve caused by endogenous neurotransmitter discharge, or competing injected drug targeting same receptors as tracer. resolution process lp-ntPET however...
Each cortical area has a distinct pattern of anatomical connections within the thalamus, central subcortical structure composed functionally and structurally nuclei. Previous studies have suggested that certain areas may more extensive target multiple thalamic nuclei, which potentially allows them to modulate distributed information flow. However, there is lack quantitative investigations into connectivity patterns thalamus. Consequently, it remains unknown if exhibit systematic differences...
Neural activity and behavior vary within an individual (states) between individuals (traits). However, the mapping of state-trait neural variation to is not well understood. To address this gap, we quantify moment-to-moment changes in brain-wide co-activation patterns derived from resting-state functional magnetic resonance imaging. In healthy young adults, identify reproducible spatiotemporal features at single-subject level. We demonstrate that a joint analysis variations feature reduction...