A5080524557- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Liver physiology and pathology
- Diverticular Disease and Complications
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Anorectal Disease Treatments and Outcomes
- Protein Tyrosine Phosphatases
- Glycosylation and Glycoproteins Research
- Urologic and reproductive health conditions
- PI3K/AKT/mTOR signaling in cancer
- Toxin Mechanisms and Immunotoxins
- Fibroblast Growth Factor Research
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Advanced Proteomics Techniques and Applications
- Proteoglycans and glycosaminoglycans research
- ATP Synthase and ATPases Research
- Cancer-related Molecular Pathways
- Microbial metabolism and enzyme function
- Paraoxonase enzyme and polymorphisms
- Sirtuins and Resveratrol in Medicine
- Multiple Myeloma Research and Treatments
Sir Run Run Shaw Hospital
2012-2025
Zhejiang University
2007-2025
Early diagnosis plays a decisive role in the outcome of colorectal cancer (CRC) therapy. The ex vivo culture fresh CRC tissues and paired normal provides feasible way to explore potential serum biomarkers for early detection under near-physiological conditions. In present work, we applied lectin affinity based approach enrich increase number secreted proteins conditioned media cultured tissues. captured were then analyzed by proteomic strategy one-dimensional gel electrophoresis coupled...
Background: Conventional neoadjuvant chemoradiotherapy (nCRT) yields a pathologic complete response (pCR) rate of 15%–30% for locally advanced rectal cancer (LARC). This study ventures to shift this paradigm by incorporating short-course nCRT with immunotherapy, specifically Envafolimab, achieve improved treatment efficacy and possibly redefine the standard care LARC. Materials methods: The PRECAM is prospective, single-arm, phase 2 clinical trial LARC in patients microsatellite stable (MSS)...
TPS3641 Background: Total neoadjuvant chemoradiotherapy is the standard of care for locally advanced rectal cancer (LARC) to control local recurrence and achieve organ preservation. However, proficient mismatch repair (pMMR) or microsatellite stable (MSS) LARC, which accounts nearly 90% cancers, conventional has limited efficacy associated with significant side effects. Recent studies have shown that combining radiotherapy immunochemotherapy can improve pathological complete response (pCR)...
Altered expression of the RON receptor tyrosine kinase, accompanied by generation splicing variants, contributes to pathogenesis epithelial cancers such as invasive growth colorectal caners. In this study, we have studied a novel variant (designated RONΔ170) that regulates tumorigenic activities cancer cells blocking RON-mediated signals. RONΔ170 is with deletion exon 19 encodes 46 amino acids in catalytic kinase domain. This also causes reading-frame shift and creates new stop codon, which...
134 Background: Chemoradiation is the standard neoadjuvant treatment for locally advanced rectal cancer. Microsatellite stable (MSS)/ mismatch repair proficient (pMMR) cancer rarely responds to immune checkpoint inhibitor monotherapy, but combination with chemoradiation may improve sensitivity of MSS/pMMR tumors by inducing immune-stimulatory effects. Therefore, we aimed investigate efficacy and safety patients treated preoperative short-course radiation followed envafolimab plus CAPEOX...
// Yu Ling 1, * , Yeye Kuang 2, Lin-Lin Chen 1 Wei-Feng Lao Yao-Ru Zhu Le-Qi Wang and Da Department of Colorectal Surgery, Sir Run Shaw Hospital, Zhejiang University Medicine, Hangzhou, 310016, People's Republic China 2 Biomedical Center, School These authors have contributed equally to this work Correspondence to: Wang, email: wangda1973@hotmail.com Keywords: RON, splicing variants, PTEN, PI3K/AKT pathway, colorectal cancer cell Received: January 06, 2017 Accepted: March 01, Published: 27,...
Background/Aim: In earlier research, we demonstrated that pyrvinium pamoate (PP) can effectively inhibit the proliferation and migration of colorectal cancer (CRC) cells. current study, further explore possibility PP, as a potential therapeutic drug in treatment CRC. Materials Methods: Hoechst 33258 staining, immunofluorescence, western blotting were used to investigate connection between PP CRC cell apoptosis autophagy. Results: We found promoted autophagy At protein level, expression...
Bcl-XL, a mitochondria membrane protein, is overexpressed in colorectal cancers and promotes cell survival. We have previously shown that the adenovector expressing small hairpin (sh)RNA targeting Bcl-XL could induce significantly apoptosis colon cancer cells. In present study, we aimed to further detect anti-cancer effect of shRNA (Ad/Bcl-XL shRNA) on rectal xenografts were derived from patient tumors.We first established three xenografts. These subsequently treated with Ad/Bcl-XL alone or...
To analyze whether the European Organisation for Treatment and Research of Cancer (EORTC) Quality Life Questionnaires (QLQ-C30 QLQ-CR29) complement low anterior resection rectum syndrome (LARS) score in evaluating quality life patients who underwent laparoscopic or robotic rectal cancer surgery. Initially, 335 surgery were randomly selected at Sir Run Shaw Hospital, Zhejiang University School Medicine from June 2013 to September 2020. All took questionnaires LARS score, QLQ-C30 QLQ-CR29....
3614 Background: Conventional neoadjuvant chemoradiotherapy (nCRT) yields a pathologic complete response (pCR) rate of about 15%–- 30% for locally advanced rectal cancer (LARC). This PRECAM study aimed to investigate the efficacy and safety short-course radiotherapy combined with CAPEOX plus Envafolimab in Patients Microsatellite Stable (MSS) LARC, redefining standard care (SOC) LARC. Methods: The is an open-label, prospective, single-arm, phase II clinical . Eligible patients MSS LARC were...
<p>Given that anastomotic leakage (AL) is a severe complication of low anterior resection (LAR) for rectal cancer, ileostomy the most common method reducing severity AL, which in turn has stoma-related side effects. A self-developed technique named stent-based diverting (SDT) not only protects anastomosis but also avoids stoma. From December 2021 to March 2023, 80 patients were randomized into arm (n = 43) or SDT 37). Demographic characteristics, laboratory test results, surgical...
Neoadjuvant chemoradiotherapy followed by total mesorectal excision is a standard treatment for locally advanced rectal cancer. Mismatch repair-deficient cancer (LARC) was highly sensitive to PD-1 blockade. However, most cancers are microsatellite stable (MSS) or mismatch repair-proficient (pMMR) subtypes which blockade ineffective. Radiation can trigger the activation of CD8 + T cells, further enhancing responses MSS/pMMR Radioimmunotherapy offers promising therapeutic modality Progenitor...
Despite improved survival rates in rectal cancer treatment, many patients experience low anterior resection syndrome (LARS). The preoperative LARS score (POLARS) aims to address the limitations of assessment by predicting outcomes preoperatively enhance surgical planning. To investigate predictive accuracy POLARS assessing occurrence LARS. This study enrolled a total 335 who underwent laparoscopic or robotic anal sphincter-preserving surgery for tumors. Patients were categorized into three...
Perianal tuberculosis (TB) is an extremely rare form of mycobacterial infection, in which the anal mucocutaneous junction becomes infected by autoinoculation from active draining gastrointestinal tract infection. The case a 73-year-old immunocompetent male patient, who came with refractory perianal ulcer presented. patient had no history TB and his lab tests for were all negative. A chest X-ray showed streak nodular opacities both upper lungs. was biopsied twice diagnosis finally rendered...
<title>Abstract</title> <bold>Background</bold> Neoadjuvant chemoradiotherapy followed by total mesorectal excision is a standard treatment for locally advanced rectal cancer. Mismatch repair-deficient cancer was highly sensitive to PD-1 blockade. However, most cancers are mismatch repair-proficient or microsatellite stable subtypes which blockade ineffective. Radiation can trigger the activation of CD8 + T cells, further enhancing responses Radioimmunotherapy offers promising therapeutic...
To investigate the effects of sodium hyaluronate on growth and adhesion colorectal cancer cells.Human cell lines SW620 Colo205 were treated with (25 -2,500 microg/ml), proliferation was measured by MTT assay in vitro. Flow-cytometric analysis applied to detect expression CD44 cells.In vitro enhanced cells, but it had no appreciable effect under same doses, Meantime, cells decreased compared controls.In has different lines, can inhibit influence their ability adhesion.
Abstract The authors have requested that this preprint be removed from Research Square.
Colonoscopic polypectomy is extremely effective in protecting against colorectal cancers, and recognition of adenomas by colonoscopy paramount importance preventing cancer (CRC) CRC-associated mortality. Incomplete polyp resection (IPR) occurs routinely medical practice following polypectomy. We conducted a comprehensive literature search to identify studies that reported on the potential risk factors for IPR using MEDLINE, EMBASE, PubMed. Publication time was limited between January 2004...