A5088099999- Global Public Health Policies and Epidemiology
- Chronic Disease Management Strategies
- Clostridium difficile and Clostridium perfringens research
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Gut microbiota and health
- Healthcare Systems and Reforms
- Diabetes Management and Education
- Mobile Health and mHealth Applications
- Cardiovascular Health and Risk Factors
- Global Cancer Incidence and Screening
- Blood Pressure and Hypertension Studies
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Virus-based gene therapy research
- Barrier Structure and Function Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Health Care Issues
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
- Cervical Cancer and HPV Research
- Vaccine Coverage and Hesitancy
- Climate variability and models
Yale University
2020-2025
Kathmandu University
2017-2025
Dhulikhel Hospital
2018-2025
University of Pittsburgh
2014-2025
Patan Academy of Health Sciences
2025
B.P. Koirala Institute of Health Sciences
2024
Government of Nepal
2023
Tribhuvan University
2019-2023
Institute for Social and Environmental Research-Nepal
2022
Rutgers, The State University of New Jersey
2022
Clostridium perfringens is an extremely versatile pathogen of humans and livestock, causing wound infections like gas gangrene (clostridial myonecrosis), enteritis/enterocolitis (including one the most common human food-borne illnesses), enterotoxemia (where toxins produced in intestine are absorbed damage distant organs such as brain). The virulence this Gram-positive, spore-forming, anaerobe largely attributable to its copious toxin production; diverse actions roles infection these now...
Childhood overweight/obesity has become a major public health concern globally because of its adverse consequences and escalating prevalence. The factors underlying the disease conditions manifested during adulthood commonly originate in childhood. Nepal is going through transition where under-nutrition co-exists with obesity; however, there lack well-documented information on childhood overweight or obesity Nepal. This study was carried out to determine prevalence associated among urban...
Significance Sickle cell anemia (SCA) is a common monogenic disorder associated with significant morbidity and mortality high incidence of unexplained sudden death in young adults. With the prevention infections, there an increasing appreciation for cardiopulmonary complications cardiac phenotype that cannot be solely attributed to chronic anemia. We used mouse models SCA iron-deficient show distinct functional, pathological, ultrastructural, molecular features causing unique restrictive...
Although previous studies have suggested alarming rise in the prevalence of hypertension Nepal, there is dearth information on its awareness, treatment and control. In this cross-sectional study, we assessed control among 298 hypertensive adults from suburban town Dhulikhel, Nepal.This study based Dhulikhel Heart Study, which included 1073 adults, aged ≥18 years, recruited randomly selected households. Comprehensive health interviews blood pressure measurements were completed during home...
Abstract Background Patient satisfaction is one proxy indicator of the health care quality; however, enhancing patient in low-income settings very challenging due to inadequacy resources as well low literacy among patients. In this study, we assess and its correlates a tertiary public hospital Nepal. Methods We conducted cross sectional study at outpatient department Bhaktapur Hospital To recruit participants for applied systematic random sampling method. Our used validated Satisfaction...
Clostridium perfringens enterotoxin (CPE) contributes to several important human gastrointestinal (GI) diseases. This toxin and its derivatives are also being explored for translational applications, i.e., cancer therapy or drug delivery. Some, but not all, members of the 24-member claudin (Cldn) family mammalian tight junction proteins can serve as CPE receptors. Among Cldns (hCldns), hCldn-3 -4 known convey sensitivity when expressed by fibroblast transfectants. However, other reportedly...
ABSTRACT In humans and livestock, Clostridium perfringens is an important cause of intestinal infections that manifest as enteritis, enterocolitis, or enterotoxemia. This virulence largely related to the toxin-producing ability C. . article primarily focuses on type F strains a very common human food poisoning many cases nonfoodborne gastrointestinal diseases. The enteric dependent their produce enterotoxin (CPE). CPE has unique amino acid sequence but belongs structurally aerolysin...
Background Inappropriate use of antimicrobials is a global public health issue, particularly in developing countries, including Nepal, where over-the-counter sales and self-medication are common. Objectives To explore knowledge, perceptions, practices their resistance among medicine dispensers community members Nepal. Methods The study was conducted three rural five urban municipalities the Kavrepalanchok district from May 2021 to August 2021. Data were collected using two qualitative...
ABSTRACT Clostridium perfringens enterotoxin (CPE) is responsible for causing the gastrointestinal symptoms of C. type A food poisoning, second most commonly identified bacterial food-borne illness in United States. CPE produced by sporulating cells small intestinal lumen, where it then causes epithelial cell damage and villous blunting that leads to diarrhea cramping. Those effects are typically self-limiting; however, severe outbreaks this particularly two occurring psychiatric...
Hypertension is a significant contributor to cardiovascular and renal diseases. In low-income settings like Nepal, there are few epidemiological studies assessing hypertension burden. Thus, the purpose was determine prevalence, awareness, treatment, control of in Nepal.A cross-sectional survey conducted semi-urban area western Nepal among randomly selected participants, aged between 25 65 years. Systolic blood pressure (BP) ≥140 mm Hg and/or diastolic BP ≥90 taking current antihypertensive...
Abstract Background Women in nursing professions are at high risk for developing varicose veins as it requires physical work and prolonged standing. The aim of the study is to estimate current prevalence among nurses Dhulikhel Hospital assess its factors. Methods A cross sectional was carried out 181 female from different clinical settings Hospital. structured questionnaire administered gather demographic, related medical history information. participants underwent Doppler ultrasound...
This study investigated the contextual factors associated with knowledge, perceptions, and willingness of frontline healthcare workers (FHWs) to work during COVID-19 pandemic in Nepal among a total 1051 FHWs. Multivariable logistic regression analysis was applied identify independent associations between predictors outcome variables. Of subjects, 17.2% reported inadequate knowledge on COVID-19, 63.6% that they perceived government response as unsatisfactory, 35.9% showed an unwillingness...
Microorganisms with antimicrobial resistance (AMR) are prevalent among humans and animals, also found in the environment. Though organisms AMR can spread to via food from animal sources, burden of food-producing animals remains largely unknown. Thus, we assessed pattern Escherichia coli isolated chicken cecum samples explored issues contributing Dhulikhel Municipality Nepal. We conducted a mixed-methods study, comprising cross-sectional quantitative component, collection cecal slaughter...
Postnatal care services helps in detecting and subsequently managing life threatening complications. With the ubiquitous use of mobile phone Nepal, social media based postpartum education has potential to increase PNC knowledge among pregnant women. This study aimed assess effect media-based health program on women attending Dhulikhel hospital, Nepal.We conducted a two-arm open-label randomized controlled trial literate visiting hospital for ANC check-up from May August, 2021. A...
Abstract Background Type 2 diabetes mellitus (T2DM) has increased globally; with a disproportionate burden in South and Southeast Asian countries, including Nepal. There is an urgent need for clinically cost-effective culturally adapted T2DM management programs. In this study, we aim to assess the effectiveness of community based appropriate lifestyle intervention improving care people T2DM. Methods We will conduct cluster randomized control trial evaluate outcomes. The be conducted 30...
Cardiovascular diseases (CVDs) are the leading cause of disease burden globally, disproportionately affecting low and middle-income countries. The continued scarcity literature on CVDs in Nepal has thwarted efforts to develop population-specific prevention management strategies. This article reports including, prevalence, incidence, disability basis as well trends over past two decades by age gender. We used Institute Health Metrics Evaluation's Global Burden Diseases database cardiovascular...