A5074813575- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Curcumin's Biomedical Applications
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Gut microbiota and health
- Sirtuins and Resveratrol in Medicine
- Bone health and osteoporosis research
- Traditional Chinese Medicine Studies
- Circular RNAs in diseases
- RNA modifications and cancer
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Reproductive Biology and Fertility
- Natural product bioactivities and synthesis
- Sperm and Testicular Function
- Traditional Chinese Medicine Analysis
- Medicinal Plant Pharmacodynamics Research
- Antioxidant Activity and Oxidative Stress
- Hydrogen's biological and therapeutic effects
Beijing University of Chinese Medicine
2015-2024
Aim. In routine histopathology, decalcification is an essential step for mineralized tissues. The purpose of this study to evaluate the effects different solutions on morphological and antigenicity preservation in Sprague Dawley (SD) rat femurs. Materials Methods. Four were employed remove mineral substances from femurs, including 10% neutral buffered EDTA, 3% nitric acid, 5% 8% hydrochloric acid/formic acid. Shaking low temperature used process samples. stainings hematoxylin-eosin (HE)...
Gut dysbiosis and oxidative stress may trigger senile osteoporosis. Fructus Ligustri Lucidi (FLL) has bone-preserving properties affects the intestinal microecology. However, mechanism of anti-osteoporotic effect FLL its link to gut microbiota remains be elucidated. Here, we demonstrated that sustained exposure ICR mice D-galactose / sodium nitrite for 90 days causes aging-related osteoporosis reduced cognitive performance. The aging phenotype is also characterized by increased in serum....
Type 2 diabetes mellitus (T2DM) is closely related to depression; however, the exact molecular mechnisms of this association are unknown. Here, we investigated whether circular RNAs (circRNAs) in blood occurrence depression patients with T2DM. Fourteen T2DM and depressive symptoms, as assessed by Self-Rating Depression Scale, were included study. Cutoff points 44 (total coarse points) 55 (standard score) used define depression. The Patient Health Questionnaire 9 was for common mental...
Background/Aims: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed investigate potential effects of on mice fed high-fat diet (HFD) explore possible mechanisms involved. Methods: Male C57BL/6J an HFD for 12 weeks were supplemented (40 mg/kg/day) via gavage additional 8 weeks....
Salvianolic acid B prevents body weight gain and improves insulin sensitivity in obese mice. The underlying mechanism behind these effects may be associated with the regulation of metabolic endotoxemia, gut microbiota homeostasis LPS/TLR4 pathway.
Purpose: Increasing evidence supported that semaphorin 3A (Sema3A), insulin-like growth factor (IGF)-1 and β-catenin were involved in the development of osteoporosis diabetes. This study is aimed to evaluate whether Sema3A/IGF-1/β-catenin directly alterations bone microarchitecture strength diabetic rats. Methods: Diabetic rats induced by streptozotocin high fat diet exposure. Bone femurs evaluated micro-CT scanning, three-point bending examination stainings HE, alizarin red S safranin...
Curcumin is an active component derived from Curcuma longa L. which a traditional Chinese medicine that widely used for treating metabolic diseases through regulating different molecular pathways. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism vivo and vitro then determine underlying mechanism. Male C57BL/6 J obese mice 3T3-L1 adipocytes were respectively. Our results demonstrated treatment with eight weeks decreased body weight,...
Purpose: This study is designed to explore whether Fructus ligustri lucidi (FLL) exhibits antioxidant effect in ovariectomized (OVX) rats, and identify the signaling pathway involved this process. Methods: OVX rats were treated with FLL aqueous extract (3.5 g/kg) for 12 weeks. Serum, uteri, tibias harvested from levels of total capacity (TAC), nitric oxide (NO), malondialdehyde (MDA), 8-hydroxy-desoxyguanosine (8-OHdG), superoxide dismutase (SOD) determined. Changes NF-κB-p65,...
This study was aimed at examining the effects of lycopene on bone metabolism in high-fat diet (HFD)- induced obese mice and to identify potential underlying mechanisms. Mice were fed a HFD for 12 weeks then continue with or without intervention (15 mg/kg) additional 10 weeks. The blood glucose lipid metabolism, as well serum levels total antioxidant capacity (T-AOC), superoxide dismutase (SOD), malondialdehyde (MDA) determined by biochemical assays. Bone histomorphological features...
Jiang Tang Xiao Ke (JTXK) granule, a Chinese herbal formula, has been used clinically to treat type 2 diabetes (T2DM) for decades. Our previous studies showed that JTXK granule exhibited anti-diabetic and anti-oxidative functions in experimental diabetic rats induced by high fat diet streptozotocin. However, the underlying mechanisms remain poorly understood. Herein, we aimed investigate therapeutic effect of on T2DM KKAy mice possible associations with skeletal muscle current study. results...
This study sought to identify sources of the reduced fertility men with type 2 diabetes mellitus. Significant reductions in semen volume, sperm concentration, and total count were observed diabetic individuals, while transmission electron microscopy revealed that structure mitochondria tail from patients was damaged. Proteins potentially associated these defects identified using proteomics. Isobaric tagging for relative absolute quantitation labeling high-performance liquid...
Purpose: Mitochondrial dysfunction in adipose tissue has emerged as key to the development of obesity and diabetes. Salvianolic acid B (SalB) is a water-soluble ingredient derived from Salvia miltiorrhiza that been shown possess potential anti-obese anti-diabetic activities. However, cellular mechanism SalB on mitochondrial function with respect these metabolic disorders not elucidated. Therefore, we aim investigate effects 3T3-L1 adipocytes analyze underlying molecular mechanism. Methods:...
Accumulating evidence suggests that mitochondrial dysfunction and adipocyte differentiation promote lipid accumulation in the development of obesity diabetes. Curcumin is an active ingredient extracted from Curcuma longa has been shown to exhibit antioxidant anti-inflammatory potency metabolic disorders. However, underlying mechanisms curcumin adipocytes remain largely unexplored. We studied effects on adipogenic oxygen consumption analysed possible mechanisms. 3T3-L1 preadipocytes were used...
Long non-coding RNAs (lncRNAs) play an important role in epigenetic regulation, and abnormalities may lead to male infertility. To investigate whether lncRNAs are involved intergenerational inheritance of obesity obesity-induced decline fertility, we divided mice into (F0 fed a high-fat diet, F0-HFD) non-obese normal chow, F0-NC) model groups their offspring (F1-HFD F1-NC, respectively). We examined the differences expression levels mRNAs F0-HFD/F0-NC F1-HFD/F1-NC groups. The results...