A5101511472- Bone Metabolism and Diseases
- Adipose Tissue and Metabolism
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Curcumin's Biomedical Applications
- Biomarkers in Disease Mechanisms
- Medicinal Plants and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Bone and Dental Protein Studies
- Bone health and osteoporosis research
- Natural Antidiabetic Agents Studies
- Medicinal Plant Pharmacodynamics Research
- Fatty Acid Research and Health
- Inflammasome and immune disorders
- Signaling Pathways in Disease
- GDF15 and Related Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Flavonoids in Medical Research
- Molecular Biology Techniques and Applications
- Geoscience and Mining Technology
- Cardiac Fibrosis and Remodeling
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Metastasis and carcinoma case studies
Beijing University of Chinese Medicine
2016-2021
Nanjing General Hospital of Nanjing Military Command
2020
Nanjing University
2004-2020
Guang’anmen Hospital
2018-2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2019
Aim. In routine histopathology, decalcification is an essential step for mineralized tissues. The purpose of this study to evaluate the effects different solutions on morphological and antigenicity preservation in Sprague Dawley (SD) rat femurs. Materials Methods. Four were employed remove mineral substances from femurs, including 10% neutral buffered EDTA, 3% nitric acid, 5% 8% hydrochloric acid/formic acid. Shaking low temperature used process samples. stainings hematoxylin-eosin (HE)...
Background/Aims: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed investigate potential effects of on mice fed high-fat diet (HFD) explore possible mechanisms involved. Methods: Male C57BL/6J an HFD for 12 weeks were supplemented (40 mg/kg/day) via gavage additional 8 weeks....
Purpose: Increasing evidence supported that semaphorin 3A (Sema3A), insulin-like growth factor (IGF)-1 and β-catenin were involved in the development of osteoporosis diabetes. This study is aimed to evaluate whether Sema3A/IGF-1/β-catenin directly alterations bone microarchitecture strength diabetic rats. Methods: Diabetic rats induced by streptozotocin high fat diet exposure. Bone femurs evaluated micro-CT scanning, three-point bending examination stainings HE, alizarin red S safranin...
Purpose: This study is designed to explore whether Fructus ligustri lucidi (FLL) exhibits antioxidant effect in ovariectomized (OVX) rats, and identify the signaling pathway involved this process. Methods: OVX rats were treated with FLL aqueous extract (3.5 g/kg) for 12 weeks. Serum, uteri, tibias harvested from levels of total capacity (TAC), nitric oxide (NO), malondialdehyde (MDA), 8-hydroxy-desoxyguanosine (8-OHdG), superoxide dismutase (SOD) determined. Changes NF-κB-p65,...
Purpose: The present study is aimed to explore whether the aqueous extract of Mori Folium (MF) exhibits bone protective effect by regulating calcium and redox homeostasis in diabetic rats, identify signaling pathways involved this process. Methods: Diabetic rats were established using high-sugar high-fat diet streptozotocin . Histopathological alterations femurs evaluated stainings hematoxylin-eosin alizarin red S. In addition, femoral strength was detected a three-point bending assay,...
Accumulating evidence suggests that mitochondrial dysfunction and adipocyte differentiation promote lipid accumulation in the development of obesity diabetes. Curcumin is an active ingredient extracted from Curcuma longa has been shown to exhibit antioxidant anti-inflammatory potency metabolic disorders. However, underlying mechanisms curcumin adipocytes remain largely unexplored. We studied effects on adipogenic oxygen consumption analysed possible mechanisms. 3T3-L1 preadipocytes were used...
Although radix Salviae miltiorrhizae (RSM) is reported to exhibit the antiosteoporotic effect in preclinical study, underlying mechanism unclear. To this end, ovariectomized (OVX) rats were employed with administration of RSM (5 g/kg) for 14 weeks. The disturbed serum levels alkaline phosphatase (ALP), osteoprotegerin (OPG), tartrate‐resistant acid phosphatase, and receptor activator nuclear factor‐κB ligand (RANKL) OVX improved by treatment. Furthermore, supplement resulted an increase...
Accumulating evidence suggests that Fructus Ligustri Lucidi (FLL) plays a beneficial role in preventing the development of osteoporosis. However, effects FLL on estrogen receptor (ER) α and ERβ expressions remain unknown. Therefore, current study we attempted to probe into ERα femurs, tibias uteri ovariectomized (OVX) rats.The OVX rats were orally administrated with water extract (3.5 g/kg/day) for 12 weeks. The uteri, serum harvested from rats. levels (E2), luteinizing hormone (LH)...
Fructus Ligustri Lucidi (FLL) has been preclinically and clinically used to treat musculoskeletal diseases. However, whether how FLL affect the canonical Wnt/β‐catenin signaling in management of osteoporosis remains largely unknown. To this end, ovariectomized (OVX) rats primary osteoblasts were administrated with aqueous extract medicated serum, respectively. Supplement OVX maintains bone quality by attenuating reduction mineral density, strength microstructure. The maintenance may be...
Coronary heart disease (CHD) is a leading cause of death and disability worldwide. Huoxue Anxin Recipe (HAR) novel Chinese Herbal Medicine formula that has been used to treat CHD for several decades. Our previous study found HAR had anti-oxidative effects, could promote myocardial angiogenesis improve cardiac function following infarction (MI) in rats. However, the active compounds, potential targets, biological processes related have not systematically investigated. Here, network...
The Jiang Tang Xiao Ke (JTXK) granule is a classic Chinese herbal formula that has been put into clinical use in the treatment of type 2 diabetes mellitus for decades. However, whether its ability to ameliorate skeletal muscle insulin resistance (IR) through modulation AMPK/SIRT1/PGC-1α signaling pathway remains unknown. Therefore, we aimed investigate effects JTXK granules on IR high-fat diet-induced diabetic mice and C2C12 cells analyze underlying mechanisms. In present study, showed...
To determine the effect of Salvianolic acid B (Sal B) on glucose and lipid metabolism in mice with high-fat diet (HFD)-induced obesity, to investigate underlying mechanisms by measuring expression levels key adipogenic transcription factors. Six-week-old C57BL/6J male were fed for 12 weeks a HFD induce obesity or standard serve as normal controls. A mean body weight increase more than 20% after these was used criteria obesity. HFD-fed obese then received supplement Sal (100 mg/kg...
A phase II study was conducted to evaluate the safety and efficacy of preoperative, intra-arterial perfusion epirubicin, etoposide, oxaliplatin combined with oral chemotherapy S-1 (SEEOX) for treatment type 4 gastric cancer.A single-center, single-arm trial on 36 patients histologically proven cancer without distant peritoneal or organ metastasis. Patients received 3, 21-day courses SEEOX preoperative chemotherapy. The primary endpoint overall survival (OS) secondary outcomes assessed were...