A5004441137- Retinoids in leukemia and cellular processes
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Lymphatic System and Diseases
- Cancer Treatment and Pharmacology
- Berberine and alkaloids research
- Plant-based Medicinal Research
- Bone Metabolism and Diseases
- Medicinal Plant Pharmacodynamics Research
- Breastfeeding Practices and Influences
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Bioactive Compounds and Antitumor Agents
- Curcumin's Biomedical Applications
- Medicinal Plants and Bioactive Compounds
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Biomarkers in Disease Mechanisms
- Traditional Chinese Medicine Analysis
- Breast Implant and Reconstruction
- Phytoestrogen effects and research
- Synthesis and Characterization of Heterocyclic Compounds
- Cytokine Signaling Pathways and Interactions
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
Beijing University of Chinese Medicine
2016-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2007-2023
First Affiliated Hospital of Xiamen University
2021
Hubei Provincial Hospital of Traditional Chinese Medicine
2013
Beijing Hospital of Traditional Chinese Medicine
2013
Nanjing Medical University
2011
The present study examined the effects of tetrandrine suppressing proliferation, targeting LC3, p62, and Beclin-1 autophagy genes by inhibiting PI3K/AKT/mTOR signaling in Triple-negative breast cancer (TNBC) MDA-MB-231 cell. Cell viability apoptosis were evaluated MTT Annexin-V/PI double staining. Cytotoxicity was determined with LDH assay. Western Blot Immunofluorescence used to measure protein levels p62/SQSTM1, Beclin1, LC3-II/LC3-I, PTEN/PI3K/AKT/mTOR signaling. Results showed that...
Background: Breast cancer has become one of the most common malignant tumors in women owing to its increasing incidence each year. Clinical studies have shown that Cinnamomum cassia (L.) J. Presl (cinnamon) a positive influence on prevention and treatment breast cancer. Aim: We aimed screen potential targets cinnamon through network pharmacology explore therapeutic mechanism cell experiments. Methods: used TCMSP, TCM Database @ Taiwan, TCMID websites established active ingredient target...
To provide novel insight into the development of new therapeutic strategies to combat breast cancer using trivalent arsenic (AsIII)-based combination therapy, cytotoxicity a AsIII and tetrandrine (Tetra), Chinese plant-derived alkaloid, was investigated in human cell line MCF-7. Cytotoxicity evaluated viability, colony formation, wound healing, lactate dehydrogenase leakage cycle assay. Alterations genes associated with proliferation death were analyzed real-time PCR western blotting....
Triple-negative breast cancer (TNBC) is a basal-like which considered to be more intrusive, have poorer prognosis and chemoresistance. TNBC characterized by the presence of epithelial mesenchymal transition (EMT) that plays major role in progression cancer. In present study, we first use classic prescription Chinese medicine Fangjihuangqi Decoction treat TGFβ1-induced MDA-MB-231 cells vitro. Our data showed cell morphology change, promoted MDA-MB 231 invasion, increased Vimentin expression,...
Based on the murine model, this study explored efficacy of Fangxia-Dihuang Decoction (FXDH) in interfering with cognitive impairment induced by doxorubicin (DOX) after chemotherapy for breast cancer. Build 4T1 cancer xenograft tumor model Balb/c mice, intraperitoneal injection DOX (5mg/kg) once a week, build related (CRCI), and administration lasted three weeks. From first while was given, FXDH given high, medium low doses gavage every day. Conduct Y-maze Novel object recognition (NOR)...
Objective: To evaluate the effect of moxibustion on relieving breast cancer–related lymphedema. Materials and Methods: A randomized controlled trial was conducted in our institution from March 2016 to 2017. All patients (N = 48) with cancer-related lymphedema were allocated 2 groups: a treatment group, which performed, control pneumatic circulation performed compression garments worn every day. Therapeutic efficacy evaluated by measuring arm circumference (wrist crease, 10 cm proximal wrist...
Tetrandrine (TET) is an alkaloid extracted from a traditional Chinese medicinal plant. It exerts remarkable anticancer activity and induces apoptotic cell death in various human cancer cells. The present study aimed to investigate the effects of TET on inhibition tumor growth induction apoptosis MDA-MB-231 breast xenograft mice. Tumor weight volume were measured. histopathological changes tissue observed. Immunohistochemistry analysis Bcl-2-associated X protein (Bax) B-cell...
The need for novel therapeutic strategies breast cancer remains paramount given the sustained development of drug resistance, tumor recurrence and metastasis. Trivalent arsenic derivatives (arsenite, AsIII) with remarkable clinical efficacy in acute promyelocytic leukemia has been demonstrated to exhibit inhibitory effect against cells. We recently that AsIII plus tetrandrine (Tetra), a Chinese plant-derived alkaloid, exerted potent antitumor activity human cells, however, underlying...
Fructus Ligustri Lucidi (FLL) has been preclinically and clinically used to treat musculoskeletal diseases. However, whether how FLL affect the canonical Wnt/β‐catenin signaling in management of osteoporosis remains largely unknown. To this end, ovariectomized (OVX) rats primary osteoblasts were administrated with aqueous extract medicated serum, respectively. Supplement OVX maintains bone quality by attenuating reduction mineral density, strength microstructure. The maintenance may be...
Dandelion (Pugongying) is one of the most frequently used Chinese herbs for treating lactational mastitis (LM). Pugongying granules, a patented medication primarily comprised dandelion extract, have been approved by CFDA LM treatment in China. The aims this study were to investigate etiology and mechanism which granules decrease symptoms, with particular focus on microbial communities found breastmilk.Participants recruited from previously performed randomized controlled trial (Identifier:...
To evaluate the effects of tetrandrine plus arsenic trioxide on HCC1937 cells, a triple negative breast cancer cell line, and to explore possible mechanisms.The 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide method was used compare antiproliferative tetrandrine, alone cells. The median-effect principle (Chou-Talalay combination index method) examine interaction between two drugs. Flow cytometry treatment with or both apoptosis. Real-time polymerase chain reaction western...
The objective of this study is to evaluate the effect Tuina combined with moxibustion on relieving breast cancer-related lymphedema (BCRL). A randomized cross-over controlled trial was conducted at our institution. All patients BCRL were assigned 2 groups: Group and B. In first period (weeks 1-4), tuina performed in pneumatic circulation compression garment washout took place from weeks 5 6. second 7-10), A, Therapeutic efficacy evaluated by measuring affected arm volume, circumference,...
In the Qing dynasty, Yanghe decoction was as a therapeutic soup for effectively treating chronic inflammatory disorders. It used clinical use of decoction, adjustment medication variety diseases have effect, including mastitis. Therefore, Jiawei (JWYHD) may be to treat breast diseases.First, LM- and JWYHD-related components were retrieved from database analysis platform. Next, protein-protein interaction networks constructed screen key targets, gene ontology Kyoto encyclopedia genome...
Background Breast cancer persists as a major public health issue on global scale. Lymphangiogenesis is an indispensable element in the promotion of breast metastasis. Inhibiting metastasis can be accomplished through targeting lymphangiogenesis. The purpose this study was to examine research trends, topics, and development directions lymphangiogenesis bibliometric analysis, which may serve reference for future clinical practice. Methods English publications with article type or review about...
The present study examined the effects of brucine on OPG/RANKL/RANK signaling pathway for exploring mechanism suppression bone metastasis in breast cancer. MDA‐MB‐231 cancer cells and mouse osteoblast MC3T3‐E1 were cocultured to mimic microenvironment vitro . qRT‐PCR Western blotting used detect expressions OPG RANKL at mRNA protein levels, respectively, brucine‐treated cultures they compared those untreated cultures. We aimed understand effect entire after analyzing these effects. Results...
The purpose of this study is to explore whether the Xiaozheng pill (XZP) has effect anti-hyperplasia mammary glands (HMG) and identify related signaling pathways.We analyzed effective chemical components XZP, as well key components, proteins, main biological processes, pathways in treatment HMG; Secondly, levels Estradiol (E2), Follicle-stimulating hormone (FSH), Luteinizing (LH), Progesterone (P), Raf/ERK/ELK HIF-1α/bFGF proteins were detected; Finally, XZP on metabolites was by...