A5033106639- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Sinusitis and nasal conditions
- Advanced biosensing and bioanalysis techniques
- Cytokine Signaling Pathways and Interactions
- Toxin Mechanisms and Immunotoxins
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- Reproductive Biology and Fertility
- Collaboration in agile enterprises
- Online and Blended Learning
- S100 Proteins and Annexins
- Advanced Drug Delivery Systems
- Luminescence and Fluorescent Materials
- Tissue Engineering and Regenerative Medicine
- Phagocytosis and Immune Regulation
- Monoclonal and Polyclonal Antibodies Research
- Educational Technology and Assessment
- Nasal Surgery and Airway Studies
- Cancer-related molecular mechanisms research
- Supramolecular Self-Assembly in Materials
- Inflammatory mediators and NSAID effects
- Head and Neck Surgical Oncology
- Elbow and Forearm Trauma Treatment
Xuzhou Medical College
2022-2024
Beijing University of Chinese Medicine
2023
Jiangyin People's Hospital
2020-2022
Animal Science Research Institute
2022
Institute of Animal Sciences
2020-2021
Nanjing Medical University
2014-2020
Guangxi University
2020
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2020
Southeast University
2020
Nanjing University of Chinese Medicine
2016-2019
The treatment for ischemic stroke is one of the most challenging problems and therapeutic effect remains unsatisfied due to poor permeation drugs across blood brain barrier (BBB). In this study, HAIYPRH (T7), a peptide that targeted transferrin receptor (TfR) can mediate transport nanocarriers BBB, was conjugated liposomes targeting novel neuroprotectant (ZL006). T7-conjugated PEGylated (T7-P-LPs) loaded with ZL006 (T7-P-LPs/ZL006) were showed satisfactory vesicle size distribution....
Abstract Glioma presents one of the most malignant brain tumors and therapeutic effect is often limited due to existence tumor barrier. Based on interleukin-13 receptor α2 (IL-13Rα2) over-expression glioma cell, it was demonstrated be a potential for targeting. In this study, Pep-1-conjugated PEGylated nanoparticles loaded with paclitaxel (Pep-NP-PTX) were developed as targeting drug delivery system treatment. The Pep-NP-PTX presented satisfactory size 95.78 nm narrow distribution. Compared...
Glioma is the most lethal brain tumor with a poor prognosis, and combination of multiple therapeutic strategies critical for postoperative glioma treatment. Herein, multifunctional hybrid hydrogel system (designated as CP&CL@RNPPTX-Gel) was developed local treatment glioma. The composed self-illuminating chlorin e6 (Ce6) conjugated luminol molecule (CL)-loaded glioma-targeting paclitaxel prodrug nanoparticles copper peroxide nanodots (CP NDs) coembedded into three-dimensional thermosensitive...
Celastrol inhibits colorectal cancer through TGF-beta1/Smad signaling Zhitao Jiang,1,* Qianyu Cao,2,* Guoliang Dai,3 Jianchun Wang,1 Chundi Liu,1 Lingyan Lv,1 Jinhuo Pan4 1Department of Pharmacy Office, Zhangjiagang Hospital Traditional Chinese Medicine Affiliated to Nanjing University Medicine, Zhangjiagang, China; 2The First Clinical College, Nanjing, 3Department Pharmacology, 4College Pharmacy, China *These authors contributed equally this work Background: There are few clinical...
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Combining treatment of anticancer cells and antiangiogenesis is considered to be a potential targeted strategy for brain glioblastoma therapy. In this study, by utilizing the overexpression Interleukin 13 receptor α2 (IL-13Rα2) on glioma heparan sulfate neovascular endothelial cells, we developed paclitaxel (PTX) loaded Pep-1 CGKRK peptide-modified PEG–PLGA nanoparticle (PC-NP-PTX) neovasculature dual-targeted chemotherapy enhance antiglioma efficacy. There were significant differences both...
The serious therapeutic obstacles to glioma treatment include poor penetration across the blood-brain barrier (BBB) and low accumulation of drugs at tumor sites. In this study, borneol combined with CGKRK peptide (a ligand heparan sulfate which overexpress on cells) modified paclitaxel prodrug self-assembled redox-responsive nanoparticles (CGKRK-PSNPs) were hypothesized enhance BBB ability active targeting efficiency, respectively. resulting CGKRK-PSNPs possessed a spherical shape small...
Follicular atresia is primarily caused by breakdown to granulosa cells (GCs) due oxidative stress (OS). MicroRNAs (miRNAs) elicit a defense response against environmental stresses, such as OS, acting gene-expression regulators. However, the association between miRNA expression and OS in porcine GCs (PGCs) unclear. Here, we examined impact of H2O2-mediated PGCs through miRNA-Seq. We identified 22 (14 upregulated 8 downregulated) 33 (19 14 differentially expressed miRNAs (DEmiRNAs) at 100 μM...
Epithelial barrier dysfunction is involved in the pathogenesis of allergic disorders, such as nasal allergy. TWIK‐related K(+) 1 (Trek1) potassium channels are required maintenance epithelial function. This study aims to investigate role antigen‐specific immunotherapy (SIT) regulation Trek1 expression mucosa. In this study, patients with allergy were treated SIT and/or Clostridium butyricum . The and histone demethylase (HDAC1) epithelia was assessed by real‐time reverse transcription...
In the Qing dynasty, Yanghe decoction was as a therapeutic soup for effectively treating chronic inflammatory disorders. It used clinical use of decoction, adjustment medication variety diseases have effect, including mastitis. Therefore, Jiawei (JWYHD) may be to treat breast diseases.First, LM- and JWYHD-related components were retrieved from database analysis platform. Next, protein-protein interaction networks constructed screen key targets, gene ontology Kyoto encyclopedia genome...
A novel candidate named 5-(3,5-dichloro-2-hydroxybenzylamino)-2- hydroxybenzoic acid (ZL006) can effectively treat focal cerebral ischemic stroke. However, the application potential of ZL006 was compromised by its poor solubility. In this study, loaded into liposomes to improve solubility and bioavailability. The particle size ZL006-loaded (LPs) about 115.5 nm with acceptable polydispersity index. in vitro release profiles indicated that could keep sustained from LPs for more than 48 h....
This study aims at, for an e-business Web site, how to use data mining technology in its management analysis, i.e. holding customer behavior patterns and digging potential customers. The connection between e-commerce was analyzed. Based on a case of consumer pattern digging, explanation gathering, filtering formatting shows different algorithms, like decision tree, neural network, genetic algorithms case-based reasoning, should be selectively taken according application backgrounds.