A5007574102- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Viral-associated cancers and disorders
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Lymphoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- RNA Research and Splicing
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Neural Networks and Applications
- Ear and Head Tumors
- Cancer, Lipids, and Metabolism
- Mycobacterium research and diagnosis
- Cancer-related gene regulation
- Advanced Radiotherapy Techniques
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
Sun Yat-sen University
2018-2024
Sun Yat-sen University Cancer Center
2018-2024
State Key Laboratory of Oncology in South China
2019-2023
University of Colorado Denver
2022
University of Colorado Cancer Center
2022
Key Laboratory of Guangdong Province
2020-2021
Long noncoding RNAs (lncRNA) play important roles in the tumorigenesis and progression of cancers. However, clinical significance lncRNAs their regulatory mechanisms nasopharyngeal carcinogenesis (NPC) are largely unknown. Here, based on a microarray analysis, we identified 384 dysregulated lncRNAs, which, FAM225A was one most upregulated NPC. significantly associated with poor survival N(6)-Methyladenosine (m6A) highly enriched within enhanced its RNA stability. functioned as an oncogenic...
The AJCC/UICC TNM classification describes anatomic extent of tumor progression and guides treatment decisions. Our comprehensive analysis 8,834 newly diagnosed patients with non-metastatic Epstein-Barr virus related nasopharyngeal carcinoma (NPC) from six Chinese centers indicates certain limitations in the current staging system. 8th edition inadequately differentiates patient outcomes, particularly between T2 T3 categories within N classification. We propose reclassifying cases NPC early...
Abstract Liquid biopsies have the utility for detecting minimal residual disease in several cancer types. Here, we investigate if liquid biopsy tracking on-treatment informs on tumour phenotypes by longitudinally quantifying circulating Epstein-barr virus (EBV) DNA copy number 673 nasopharyngeal carcinoma patients undergoing radical induction chemotherapy (IC) and chemo-radiotherapy (CRT). We observe significant inter-patient heterogeneity viral clearance that is classifiable into eight...
Alternative splicing (AS) has emerged as a key event in tumor development and microenvironment formation. However, comprehensive analysis of AS its clinical significance head neck squamous cell carcinoma (HNSC) is urgently required. Methods: Genome-wide profiling events using RNA-Seq data from The Cancer Genome Atlas (TCGA) program was performed cohort 464 patients with HNSC. Cancer-associated (CASEs) were identified between paired HNSC adjacent normal tissues evaluated functional enrichment...
Abstract Frontier evidence suggests that dysregulation of long noncoding RNAs (lncRNA) is ubiquitous in all human tumors, indicating lncRNAs might have essential roles tumorigenesis. Therefore, an in-depth study the lncRNA nasopharyngeal carcinoma (NPC) carcinogenesis be helpful to provide novel therapeutic targets. Here we report TINCR was significantly upregulated NPC and associated positively with poor survival. Silencing inhibited progression cisplatin resistance. Mechanistically, bound...
Background The current study was performed to investigate whether circulating cell‐free Epstein‐Barr virus DNA (cfEBV DNA) would be useful for posttreatment surveillance in patients with nasopharyngeal carcinoma (NPC). Methods authors identified a total of 1984 nondisseminated NPC from an institutional big‐data research platform. Blood samples were collected within 3 months the completion radiotherapy and every 12 thereafter cfEBV analysis. Patients followed until disease recurrence detected...
Background: Head and neck adenoid cystic carcinoma (ACC) is a rare malignant tumor that prone to local recurrence. The NCCN Guidelines for Neck Cancers recommend all patients with ACC receive postoperative radiotherapy (PORT). However, whether PORT can improve control which benefit from are unknown. This study aimed assess the role of provide individualized suggestions therapy in ACC. Patients Methods: We retrospectively reviewed nonmetastatic head who underwent surgery or without PORT....
An increasing number of clinical trials are being conducted exploring the efficacy neoadjuvant immune checkpoint inhibitors. Surrogate end-points for overall survival (OS) urgently needed.Phase II or III immunotherapy that reported data on OS and surrogate were identified from January 1, 2000, to November 25, 2022. Individual patient data, trial-level requested corresponding authors extracted eligible trials. At individual level, correlations between radiological pathological response...
Abstract The optimal post-treatment surveillance strategy that can detect early recurrence of a cancer within limited visits remains unexplored. Here we adopt nasopharyngeal carcinoma as the study model to establish an approach balances effectiveness disease detection versus costs. A total 7,043 newly-diagnosed patients are grouped according clinic-molecular risk grouping system. We use random survival forest simulate monthly probability recurrence, and thereby risk-based arrangements...
The value of post-neoadjuvant chemotherapy (NACT) tumor volume for prognostication in loco-regionally advanced nasopharyngeal carcinoma (LA-NPC) is unascertained. Here, we recruited 4109 histologically proven LA-NPC (stage III-IVA) that were treated with radical chemo-intensive-modulated radiotherapy (IMRT). Post-NACT gross primary (GTVp) and lymph node (GTVnd) volumes each patient calculated from planning computed tomography (CT). We observed similar linear association between GTVp/GTVnd...
To develop a risk stratification model based on the International Federation of Gynecology and Obstetrics (FIGO) staging combined with squamous cell carcinoma antigen (SCC-Ag) for classification patients cervical (CSCC) into different groups.We retrospectively reviewed data 664 women stage IIA-IVB CSCC according to 2018 FIGO system who received definitive radiotherapy from March 2013 December 2017 at department radiation oncology Sun Yat-sen University Cancer Center. Cutoff values continuous...
Significance of plasma Epstein-Barr virus deoxyribonucleic acid (EBV DNA)-a proven robust indicator for nasopharyngeal carcinoma (NPC)-is not yet clarified in risk stratification metastatic NPC (mNPC). We aim to establish effective M1 stage subdivisions mNPC by integrating radiological features and EBV DNA at diagnosis metastasis (mEBV DNA).The study comprised 1,007 patients, including 817 metachronous (mmNPC) patients randomized into training (n=613) internal validation (n=204) cohorts, 190...
To quantify the long-term evaluation of optic chiasma (OC) and/or nerve(s) (ONs) and to develop predictive models for radiation-induced neuropathy (RION) in nasopharyngeal carcinoma after intensity-modulated radiotherapy (IMRT). A total 3,662 patients' OC/ONs with full visual acuity dosimetry data between 2010 2015 were identified. Critical predictors RION chosen by machine learning penalized regression survival. nomogram containing clinical variables was generated predicting RION-free The...
We investigated the clinical characteristics, prognostic factors, and post-recurrence factors of early- late-recurrence patients for nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiation therapy (IMRT). This was a single-center retrospective analysis in China from January 2010 to December 2015. The overall survival (OS) OS were identified using univariate multivariate Cox regression analyses. Of 9,468 included, 409 (4.3%), 325 (3.4%), 182(1.9%) developed purely local...
The objective of this study was to construct a risk classification system integrating cell-free Epstein-Barr virus (cfEBV) DNA with T- and N- categories for better prognostication in nasopharyngeal carcinoma (NPC).Clinical records 10,149 biopsy-proven, non-metastatic NPC were identified from two cancer centers; comprised training (N = 9,259) validation cohorts 890; including one randomized controlled phase 3 trial cohort). Adjusted hazard ratio (AHR) method using two-tiered stratification by...