A5101704566- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Neuroendocrine regulation and behavior
- Gut microbiota and health
- Nutritional Studies and Diet
- Biochemical effects in animals
- Hormonal Regulation and Hypertension
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Fatty Acid Research and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Signaling Pathways in Disease
- Biological Activity of Diterpenoids and Biflavonoids
- Ubiquitin and proteasome pathways
- ATP Synthase and ATPases Research
- Herbal Medicine Research Studies
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Traditional Chinese Medicine Analysis
- Nerve injury and regeneration
- CRISPR and Genetic Engineering
- Meat and Animal Product Quality
University of Hong Kong - Shenzhen Hospital
2020-2024
University of Hong Kong
2014-2024
Chinese University of Hong Kong
2014-2024
Chengdu University of Traditional Chinese Medicine
2022-2023
Chinese PLA General Hospital
2023
Chinese People's Liberation Army
2023
Chinese Center For Disease Control and Prevention
2018
Yakult (Netherlands)
2009-2015
Neuroinflammation has been suggested that affects the processing of depression. There is renewed interest in berberine owing to its anti-inflammatory effects. Herein, we investigated whether attenuate depressive-like behaviors via inhibiting NLRP3 inflammasome activation mice model depression.Adult male C57BL/6N were administrated corticosterone (CORT, 20 mg/kg/day) for 35 days. Two doses (100 mg/kg/day and 200 orally from day 7 until 35. Behavioral tests performed measure depression-like...
Summary Aim Nerve growth factor ( NGF ) regulates neuronal survival and differentiation by activating extracellular signal‐regulated‐kinases ERK 1/2 phosphoinositide‐3‐kinase PI 3K)/Akt pathways in two distinct processes: latency process neurite extension process. This study was designed to investigate whether botanical drug C‐glucosylated isoflavone puerarin coordinates with regulate neuritogenesis via 3K/Akt Methods We investigated the neuroprotective neurotrophic activities of MPTP...
Abstract This report summarises talks given at the 8th International Yakult Symposium, held on 23–24 April 2015 in Berlin. Two presentations explored different aspects of probiotic intervention: small intestine as a target and inclusion probiotics into integrative approaches to gastroenterology. Probiotic recommendations gastroenterology guidelines current data efficacy paediatric patients were reviewed. Updates gut microbiota research obesity obesity-related diseases, gut–brain axis...
Background: Inflammation and fibrosis are typical symptoms of non-alcoholic steatohepatitis (NASH), which is one the most common chronic liver diseases. The cGAS-STING signaling pathway has been implicated in progression NASH, targeting this may represent a new therapeutic strategy. Licorice widely used herb with anti-inflammatory liver-protective properties. In study, we assessed effect licorice extract on pathway. Methods: Bone marrow-derived macrophages (BMDMs) were treated then...
Abstract Neuroinflammation hallmarks the pathology of depression although etiological complexity has not yet been resolved. Previous studies demonstrate that bacterial lipopolysaccharide induces depressive‐like behaviors by activating RagA‐mTOR‐p70S6K signaling pathway. The current project aims to investigate whether and how brain‐specific RagA overexpression triggers in mice. Full‐length cDNA is cloned into mammalian expression vector under control brain specific promoter, subsequently...
Progesterone receptor (PR) modulates neuroprotective and regenerative responses in Parkinson's disease related neurological diseases. The present study was designed to determine whether botanical drug puerarin could exhibit neurorestorative activities via PR signaling. neurotrophic of were investigated MPTP-lesioned mice MPP+-challenged primary rat midbrain neurons. Rotarod performance test tail suspension used assess motor functions. Tyrosine hydroxylase (TH) determined by immunostaining,...
Myocardial infarction (MI) is a highly prevalent and lethal disease worldwide. Prevention timely recovery are critical for the control of recurrence heart failure in MI survivors. The present study was designed to investigate cardioprotective activity herbal medicine formula Baoyuan Decoction (BYD) identify active compounds molecular targets. ethanolic BYD extract (BYDE) prepared by water extraction ethanol precipitation four medicines, Astragali Radix, Ginseng Radix et Rhizoma, Cinnamomi...
Background & Objective: Alzheimer’s disease (AD) and Parkinson’s (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve core symptoms AD PD in a temporary manner cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed pharmacokinetics eight potent natural products druggability discussed underlying...
The development of a new triggered-release system for selective detection catecholamines in biological samples including living cells is reported. Catecholamines are class tightly regulated hormones and neurotransmitters the human body their dysregulation implicated various neurodegenerative diseases. It highly challenging to selectively sense detect complex environment due small size, non-specific molecular shape trivial chemical properties. In this study, copper-based,...
Aberrant microglial activation drives neuroinflammation and neurodegeneration in Alzheimer’s disease (AD). The present study is aimed at investigating whether the herbal formula Qi-Fu-Yin (QFY) could inhibit inflammatory of cultured BV-2 microglia. A network pharmacology approach was employed to predict active compounds QFY, protein targets, affected pathways. representative pathways molecular functions targets were analyzed by Gene Ontology (GO) pathway enrichment. total 145 selected from...
Abstract Background Bacterial infection is a potential risk factor for depression. However, little known about the mechanistic link between bacterial endotoxin and depressive-like behaviors. The aim of present study was to clarify whether liposaccharide (LPS) could induce behaviors in mice via sequentially activating small GTPase RagA, mammalian target rapamycin (mTOR), p70S6K. Methods C57BL/6 N were treated with 0.83 mg/kg LPS by intraperitoneal injection 24 h. animals assessed forced swim...
Background: Small ubiquitin-like modifier (SUMO) proteins modify through SUMOylation as an essential protein post-translational modification (PTM) for regulating redox status, inflammation, and cardiac fibrosis in myocardial infarction. This study aimed to investigate whether natural product puerarin could alleviate ischemia/reperfusion injury (MI-RI) by targeting SUMOylation. Methods: Mouse MI-RI model was induced ligating the left anterior descending (LAD) coronary artery subsequently...
Background . The depressive symptom hallmarks the progression of neurodegenerative diseases, especially Alzheimer’s disease. Bacterial infection is related to inflammation and depression. present project thereby examined whether botanical drug puerarin could attenuate liposaccharide‐ (LPS‐) induced behaviors in mice. Methods Adult male C57BL/6N mice were sequentially treated with LPS evaluated for by tail suspension test forced swim test. brain tissues profiled molecular targets...
A new aromatic glycoside (1) and a natural product, neolignan (2), along with twenty-three known compounds (3-25), were isolated from the thorns of Gleditsia sinensis. According to spectroscopic analyses (IR, UV, HRESIMS, NMR ECD), structures isolates elucidated. Herein, 4, 6-8, 10-13, 15, 16, 18, 20, 23 plant G. sinensis for first time. Moreover, 6, 15 24 showed cytotoxic effects on human ovarian cancer (SKOV-3) cells IC50 values 24.83 ± 4.90, 48.86 9.11, 80.13 5.62, 15.38 2.21 μM, respectively.
To explore whether the modified Qing' e Pills (MQEP) exerts anti-osteoporotic effects and prevents bone loss by enhancing angiogenesis.Network pharmacology was used to assess MQEP has a pro-angiogenic capacity predict its potential targets. Human umbilical vein endothelial cells were treated with glucocorticoids cell viability. The expression of angiotensin II type 1 receptor, 2 converting enzyme, which are associated activation renin-angiotensin-aldosterone system, vascular growth factor...
Ras-related GTP-binding protein A (RagA), encoded by RRAGA gene, initially senses the availability of cellular amino acids (e.g., leucine) and controls translocation mTORC1 to lysosomal membrane. RagA overexpression appears be associated with onset depression. To discover biological roles RagA, we employed CRISPR/Cas9 system generate a gene knockout stem cell line from human induced pluripotent (iPSC) iPSN0003. Such iPSC may help development new therapeutics for
Since exploding rates of modern mental diseases, application antidepressants has increased. Worryingly, the antidepressant-induced liver injury gradually become a serious health burden. Furthermore, since most knowledge about antidepressant hepatotoxicity are from pharmacovigilance and clinical case reports lack observational studies, underlying mechanisms poorly understood there is efficient treatment strategies. In this study, paroxetine directly triggered inflammasome activation evidenced...