A5006675553- Advanced MRI Techniques and Applications
- Fractional Differential Equations Solutions
- Advanced Neuroimaging Techniques and Applications
- NMR spectroscopy and applications
- Ultrasound Imaging and Elastography
- Advanced NMR Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Lipid Membrane Structure and Behavior
- Microfluidic and Capillary Electrophoresis Applications
- Elasticity and Material Modeling
- Nanoparticle-Based Drug Delivery
- Electron Spin Resonance Studies
- Osteoarthritis Treatment and Mechanisms
- Ultrasonics and Acoustic Wave Propagation
- Microfluidic and Bio-sensing Technologies
- Lanthanide and Transition Metal Complexes
- Electromagnetic Fields and Biological Effects
- Photoacoustic and Ultrasonic Imaging
- Wireless Body Area Networks
- Microbial Inactivation Methods
- Spectroscopy and Quantum Chemical Studies
- MRI in cancer diagnosis
- Thermoelastic and Magnetoelastic Phenomena
- Pancreatic function and diabetes
- Mesenchymal stem cell research
University of Illinois Chicago
2014-2023
University of Illinois Urbana-Champaign
1997-2020
Technical University of Košice
2019
Rzeszów University of Technology
2019
Universidad de Extremadura
2019
University of Rochester
1974-2018
Bioengineering Center
1978-2011
University of Chicago
2006
University of Illinois System
1984-2005
National Cancer Institute
1977-2005
Abstract We have developed a new class of magnetic resonance imaging contrast agents with large proton relaxation enhancements and high molecular relaxivities. The reagents are built from the polyamidoamine form Starburs™ dendrimers in which free amines been conjugated to chelator 2‐(4‐isothiocyanatobnenzyl)‐6‐methyl‐diethylenetriaminepenta‐acetic acid. dendrimer gadolinium poly‐chelates enhancement factors, i.e., ratlo relaxivity per Gd(III) ion that Gd(III)‐diethylenetriaminepentaacetic...
Fractional calculus (integral and differential operations of noninteger order) is not often used to model biological systems. Although the basic mathematical ideas were developed long ago by mathematicians Leibniz (1695), Liouville (1834), Riemann (1892), others brought attention engineering world Oliver Heaviside in 1890s, it was until 1974 that first book on topic published Oldham Spanier. Recent monographs symposia proceedings have highlighted application fractional physics, continuum...
High-resolution, proton nuclear magnetic resonance (NMR) spectra of 5-nanoliter samples have been obtained with much higher mass sensitivity [signal-to-noise ratio (S/N) per micromole] than traditional methods. Arginine and sucrose show a mean enhancement 130 compared to 278-microliter run in 5-millimeter tube conventional, commercial probe. This can reduce data acquisition time by factor >16,000 or the needed sample about 130. A linewidth 0.6 hertz was achieved on 300-megahertz...
Abstract The brain's attentional system identifies and selects information that is task-relevant while ignoring task-irrelevant. In two experiments using functional magnetic resonance imaging, we examined the effects of varying compared to task-irrelevant information. first experiment, patterns activation as demands were increased for Stroop tasks differed in information, but not information: a color-word task spatial-word task. Distinct subdivisions dorsolateral prefrontal cortex precuneus...
Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated 42 C unheated control tumors. Most of the accumulated drug appeared be intracellular and bound dihydrofolate reductase, enzyme blocked by in its role an antineoplastic agent.
The tissue electrode interface is common to all forms of biopotential recording (e.g., ECG, EMG, EEG) and functional electrical stimulation pacemaker, cochlear implant, deep brain stimulation). Conventional lumped element circuit models electrodes can be extended by generalization the order differentiation through modification defining current-voltage relationships. Such fractional provide an improved description observed bioelectrode behaviour, but recent experimental studies cardiac...
It is well known that diffusion-induced MR signal loss deviates from monoexponential decay, particularly at high b-values (e.g., >1500 sec/mm2 for human brain tissues). A number of models have been developed to describe this anomalous diffusion behavior and relate the measurements tissue structures. Recently, a new model was proposed by solving Bloch-Torrey equation using fractional order calculus with respect time space (Magin et al., J Magn Reson 2008;190:255-270; Zhou Proc Int'l Soc Med...
Abstract Nuclear magnetic resonance (NMR) is a physical phenomenon widely used in chemistry, medicine, and engineering to study complex materials. NMR governed by the Bloch equation, which relates macroscopic model of magnetization applied radiofrequency, gradient static fields. Simple models materials are well described classical first order dynamics precession relaxation inherent vector form equation. Fractional generalization equation presents an opportunity extend its use describe wider...
Purpose In diffusion‐weighted MRI studies of neural tissue, the classical model assumes statistical mechanics Brownian motion and predicts a monoexponential signal decay. However, there have been numerous reports decays that are not monoexponential, particularly in white matter. Theory We modeled diffusion tissue from perspective continuous time random walk. The characteristic decay is represented by Mittag‐Leffler function, which relaxes priori assumptions about governing statistics. then...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1H-NMR Spectroscopy on the Nanoliter Scale for Static and Online MeasurementsNian. Wu, Timothy L. Peck, Andrew G. Webb, Richard Magin, Jonathan V. SweedlerCite this: Anal. Chem. 1994, 66, 22, 3849–3857Publication Date (Print):November 15, 1994Publication History Published online1 May 2002Published inissue 15 November 1994https://pubs.acs.org/doi/10.1021/ac00094a003https://doi.org/10.1021/ac00094a003research-articleACS PublicationsRequest reuse...
Abstract Human lymphocytes were labeled with biotinylated anti‐lymphocyte‐directed monoclonal antibodies, to which streptavidin and subsequently dextran‐magnetite particles coupled. This labeling resulted in a strong selective negative contrast enhancement of lymphocyte suspensions at 2.0 T, caused predominantly by the specific increase R 2 small but significant . The 1 was found decrease increasing field strength. immunolabeling procedure described here may be used for signal depletion...
Abstract Human peripheral blood mononuclear cells (PBMCs) were incubated with large unilamellar vesicles (LUV) containing encapsulated dextran‐magnetite particles (DMP). This resulted in an efficient incorporation of DMP. Electron microscopy revealed the presence DMP mainly phagosomes and secondary lysosomes. DMP‐labeled PBMCs showed a strong increase transverse relaxation rate (up to 16.6 s −1 for 5 x 10 7 cells/ml) and, accordingly, great loss signal intensity MR imaging. The fraction...
Abstract Localized electron spin resonance spectroscopy in Live mice was performed using a surface coil operating at 1.1 GHz with sufficient sensitivity and stability to measure quantitatively the time course of distribution, uptake, reduction nitroxides selected organsfregions (liver, bladder, head) mice. The ability regional concentrations vivo could be used for pharmacokinetic analysis drugs labeled measurement oxygen redox metabolism. © 1989 Academic Press, Inc.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNanoliter Volume Sample cells for 1H NMR: Application to Online Detection in Capillary ElectrophoresisNian Wu, Timothy L. Peck, Andrew G. Webb, Richard Magin, and Jonathan V. SweedlerCite this: J. Am. Chem. Soc. 1994, 116, 17, 7929–7930Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00096a073https://doi.org/10.1021/ja00096a073research-articleACS...