A5016599969- Aquaculture Nutrition and Growth
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Aquaculture disease management and microbiota
- Sulfur-Based Synthesis Techniques
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Neuroscience and Neural Engineering
- Chemical Synthesis and Reactions
- Animal Nutrition and Physiology
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Neuroscience and Neuropharmacology Research
- Peroxisome Proliferator-Activated Receptors
- Physiological and biochemical adaptations
- MicroRNA in disease regulation
- Moringa oleifera research and applications
- Oxidative Organic Chemistry Reactions
- Infant Nutrition and Health
- Gut microbiota and health
- ATP Synthase and ATPases Research
- Phytase and its Applications
Guangxi Academy of Sciences
2022-2024
Chengdu Medical College
2024
Guangxi University
2024
Guangdong Ocean University
2021-2023
Sichuan University
2011-2022
State Key Laboratory of Biotherapy
2011-2022
Shaoyang University
2022
Nanjing Tech University
2019-2021
The Synergetic Innovation Center for Advanced Materials
2020
Huazhong Agricultural University
2010-2019
A direct electrochemical oxidative cyclization of activated alkynes with diselenides or disulfides toward functionalized coumarins and quinolinones has been developed.
A novel and green route has been developed for the electrochemical synthesis of spiro[4.5]trienones through radical-initiated dearomative spirocyclization alkynes with diselenides. This metal-free oxidant-free electrosynthesis reaction was performed in an undivided cell under mild conditions. variety selenation products were prepared moderate-to-good yields, showing a broad scope functional group tolerance. Moreover, continuous-flow system combined possesses potential to achieve scaled-up...
Oxidative phosphorylation is an important biological process in the body to produce energy, during which oxygen free radicals are generated as byproduct. Excessive cause cell death and reduce rate of tissue regeneration healing a wound. Lignin natural antioxidant derived from plants, but its biomedical application restricted because uncertain biocompatibility. In this work, we developed lignin-incorporated nanogel explored for wound healing. was extracted coconut husks determined have strong...
Dietary bile acid (BA) supplementation can notably ameliorate fatty liver disease caused by high dietary lipids, but the mechanism behind this is poorly understood. The present study was aimed at gaining insight into how TCA (taurocholic sodium) reduced hepatic lipid accumulation via regulation of metabolism. We explored BA metabolism in juvenile hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂). Three trials were: (1) fed control, (HD) or gradient diet; (2) a diet with without...
Voltage-gated potassium (K+) channels are assembled by four identical or homologous alpha-subunits to form a tetrameric complex with central conduction pore for ions. Most of the cloned genes classified into subfamilies: Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw), and Kv4 (Shal). Subfamily-specific assembly heteromeric K+ channel complexes has been observed in vitro vivo, which contributes diversity currents. However, molecular codes that mediate subfamily-specific association remain unknown. To...
There are at least five subfamilies of Shaker-like K+ channels. The diverse functions channels thought to be further modulated by hydrophilic β subunits. Here we report that Kvβ1 inactivates RCK4 and Shaker B the Kv1 subfamily, but not Shal2 Kv4 subfamily. This correlates subfamily-specific binding cytoplasmic N-terminal domains α We map Kvβ1-binding site a region overlapping NABKv1, domain specifies different subunits form heterotetramers. Using chimeric subunits, demonstrate NABKv1 is...
Bile acids (BAs) usually display growth-promoting and lipid-lowering properties when supplemented to the diet. The effects of a high-lipid diet (HD) BAs supplementation on growth performance lipid deposition hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) was evaluated in this study. Compared control (CD), HD did not significantly affect fish performance, but it promoted deposition, as revealed by higher crude content whole body, muscle, liver. Among with taurocholic acid (BD)...
Targeting of protein modification enzymes is a key biochemical step to achieve specific and effective posttranslational modifications. Two alternatively spliced ZIP1 ZIP2 proteins are described, which bind both Kvbeta2 subunits potassium channel kinase C (PKC) zeta, thereby acting as physical link in the assembly PKCzeta-ZIP-potassium complexes. differentially stimulate phosphorylation by PKCzeta. They also interact form heteromultimers, allows for hybrid stimulatory activity Finally,...
Japanese encephalitis virus (JEV) can cause severe central nervous disease with a high mortality rate. There is no antiviral drug available for JEV-specific treatment. In this study, cytopathic-effect-based, high-throughput screening assay was developed and applied to screen JEV inhibitors from Library of Pharmacologically Active Compounds 1280. The effects three hit compounds including FGIN-1-27, cilnidipine, niclosamide were evaluated in cells by western blotting, indirect...
Abstract The efficient regio‐ and stereoselective construction of tetrasubstituted alkenes is challenging very important. For this purpose, we have developed an approach to synthesize trifluoromethylthiolated from simple alkynes in excellent stereoselectivities by selenide‐catalyzed multicomponent coupling. Using method, alkenyl triflates arenes were achieved. In particular, the could be further converted into carbofunctionalized palladium‐catalyzed cross‐coupling reactions. Our method...
Chiral selenide-catalyzed oxytrifluoromethylthiolation of aliphatic internal alkenes by a formally intermolecular strategy is disclosed, affording CF3S 1,3-amino alcohol and 1,3-diol derivatives with high regio-, enantio-, diastereoselectivities. The reactions are promoted neighboring imide or ester group on substrates via six-membered ring transition state. This assistance also successfully applied to the regio- diastereoselective oxyhalofunctionalization conversion alkynes.
HERG (human eag-related gene) encodes an inward-rectifier potassium channel formed by the assembly of four subunits. Since truncated protein in patients with long QT syndrome induces a dominant phenotype, that is, cardiac sudden death, nonfunctional complexes between wild-type and mutated subunits was implicated causing disease. To understand HERG-mediated death at molecular level, it is important to determine which regions participate subunit interaction. We therefore report identification...
Unintended inhibition of the cardiac potassium channel human ether-a-go-go-related gene (hERG) is considered main culprit in drug-induced arrhythmias known as torsades de pointes. Electrophysiology most reliable vitro screening method for identifying potential hERG liabilities, but only recent advent planar electrode-based voltage clamp electrophysiology promises sufficient throughput to support drug testing needs discovery programs. We have assessed reliability this new format technology...
An efficient and green electrochemical continuous flow approach has been developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2<italic>H</italic>,4<italic>H</italic>)-diones through sulfonylation alkenes under metal-free oxidant-free conditions.
A novel method for the continuous synthesis of selenated iminoisobenzofurans by cyclization olefinic amides with diselenides through electrochemical oxidation under metal-free and oxidant-free conditions has been developed.
Although conventional patch-clamp methods provide high information content, they are labor-intensive and suffer from low throughput overall cost. Several approaches for achieving electrophysiology under development, among which microchip-based systems uniquely achieve a higher degree of miniaturization, faster perfusion mixing, lower reagent cost without losing content. The goal this study was to establish benchmark our biochip technology with 52 chips tested sequentially. We demonstrate...
The present study investigated growth performance, body composition, hepatic and intestinal morphology, biochemical indices, transcriptomic responses, metabolomic profiles in giant freshwater prawn ( Macrobrachium rosenbergii ) fed six kinds of soy protein concentrate (SPC) diets over an 8‐week feeding trial. SPC were formulated by replacing varying proportions fishmeal (FM) with SPC, the final percentage FM set at 350, 280, 210, 140, 70, 0 g/kg, respectively, designated as F35, F28, F21,...