A5101983924- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Genomic variations and chromosomal abnormalities
- Hepatitis B Virus Studies
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Transportation Planning and Optimization
- Vibrio bacteria research studies
- Acute Lymphoblastic Leukemia research
- Phagocytosis and Immune Regulation
- Forecasting Techniques and Applications
- Sex work and related issues
- Advanced Statistical Methods and Models
- Salmonella and Campylobacter epidemiology
- Urban Transport and Accessibility
- Reproductive tract infections research
- Dental Implant Techniques and Outcomes
- Cellular Mechanics and Interactions
- Cervical Cancer and HPV Research
- Virology and Viral Diseases
Centers for Disease Control and Prevention
2016-2025
Fifth Affiliated Hospital of Zhengzhou University
2010-2025
University of Portsmouth
2012-2025
Center for Global Health
2022-2024
State Ethnic Affairs Commission
2021-2024
Wuhan University
2024
Qingdao University
2024
Qingdao Municipal Hospital
2024
Zhongnan Hospital of Wuhan University
2024
Ohio University
2010-2023
<h3>Context</h3>Incidence of human immunodeficiency virus (HIV) in the United States has not been directly measured. New assays that differentiate recent vs long-standing HIV infections allow improved estimation incidence.<h3>Objective</h3>To estimate incidence States.<h3>Design, Setting, and Patients</h3>Remnant diagnostic serum specimens from patients 13 years or older newly diagnosed with during 2006 22 states were tested BED HIV-1 capture enzyme immunoassay to classify as long-standing....
The estimated number of new HIV infections in the United States reflects leading edge epidemic. Previously, CDC incidence 2006 as 56,300 (95% CI: 48,200-64,500). We updated estimate and calculated for 2007-2009 using improved methodology.We surveillance data from 16 states 2 cities a modification our previously described stratified extrapolation method based on sample survey approach with multiple imputation, stratification, to account missing heterogeneity testing behavior among population...
The best indicator of the impact human immunodeficiency virus (HIV) prevention programs is incidence infection; however, HIV a chronic infection and diagnoses may include infections that occurred years before diagnosis. Alternative methods to estimate use diagnoses, stage disease, laboratory assays recency. Using consistent, accurate method would allow for timely interpretation trends.The objective our study was assess recent progress toward reducing in United States overall among selected...
Persons who inject drugs (PWID) are at increased risk for poor health outcomes and bloodborne infections, including human immunodeficiency virus (HIV), hepatitis C B infections. Although substantial progress has been made in reducing HIV infections among PWID, recent changes drug use could challenge this success.CDC used National Surveillance System data to analyze trends diagnoses. Further, Behavioral interviews of PWID 22 cities were analyzed describe behaviors prevention services all...
Fluorescence imaging using probes with two-photon excitation and near-infrared emission is currently the most popular in situ method for monitoring biological species or events, a large depth, low background fluorescence, optical damage, high spatial temporal resolution. Nevertheless, current fluorescent dyes still have some disadvantages such as poor water solubility, fluorescence quantum yield, small absorption cross sections. These drawbacks are mainly caused by structural characteristics...
We examined racial/ethnic disparities in HIV diagnosis rates for persons aged 50 years and older.
The search for target genes involved in unbalanced acquired chromosomal abnormalities has been largely unsuccessful, because the breakpoints of these rearrangements are too variable. Here, we use example dicentric chromosomes B cell precursor acute lymphoblastic leukemia to show that, despite this heterogeneity, single targeted through a variety mechanisms. FISH showed although they were heterogeneous, on 9p resulted partial or complete deletion PAX5. Molecular copy number counting further...
Serological surveys provide an objective biological measure of population immunity, and tetanus serological can also assess vaccination coverage. We undertook a national assessment immunity to diphtheria among Nigerian children aged <15 years using stored specimens collected during the 2018 Nigeria HIV/AIDS Indicator Impact Survey, cross-sectional household-based survey. used validated multiplex bead assay test for toxoid-antibodies. In total, 31,456 were tested. Overall, 70.9% 84.3% had at...
Abstract Background The World Health Organization recommends vaccines for prevention and control of typhoid fever, especially where antimicrobial-resistant circulates. In 2018, the Navi Mumbai Municipal Corporation (NMMC) implemented a conjugate vaccine (TCV) campaign. campaign targeted all children aged 9 months through 14 years within NMMC boundaries (approximately 320 000 children) over 2 vaccination phases. phase 1 occurred from July 2018 25 August (71% coverage, approximately 113 420...
Abstract Prior research has established associations between immune cells, inflammatory proteins, and chronic kidney disease (CKD). Our Mendelian randomization study aims to elucidate the genetic causal relationships among these factors CKD. We applied using variants associated with CKD from a large genome-wide association (GWAS) markers comprehensive GWAS summary. The links exposures (immune cell subtypes proteins) were primarily analyzed inverse variance-weighted, supplemented by...
The ETV6-RUNX1 fusion is the molecular consequence of t(12;21)(p13;q22) seen in approximately 25% children with acute lymphoblastic leukemia (ALL). Studies have shown that alone insufficient for initiation leukemia; additional genetic changes are required. Genomic profiling identified copy number alterations at high frequencies these patients. Focal deletions TBL1XR1 were observed 15% cases; 3 patients exhibited distal to gene. Fluorescence situ hybridization confirmed and quantitative...
To determine the status of HIV epidemic in United States and Canada.We used data on AIDS diagnoses for 1996-2005 reported to Canadian national surveillance systems trends (33 US states only) identify population groups most affected by HIV. incidence Canada was determined using back-calculation methods. We also proportion persons diagnosed late (HIV diagnosis within 12 months before diagnosis).AIDS rates were higher 2005 among blacks (54.1 per 100,000) Hispanics (18.0) compared with whites...
// Mikaella Vouri 1 , Qian An Matthew Birt Geoffrey J. Pilkington and Sassan Hafizi Institute of Biomedical Biomolecular Science, School Pharmacy Sciences, University Portsmouth, UK Correspondence to: Hafizi, email: Keywords : Axl receptor tyrosine kinase, small molecule inhibitor, glioma, invasion Received December 03, 2014 Accepted April 09, 2015 Published 29, Abstract Glioblastoma multiforme (GBM) often features a combination tumour suppressor gene inactivation multiple oncogene...
Much has been written about the impact of human immunodeficiency virus (HIV) among young (13-24) sexual minority men (SMM). Evidence for concern is substantial emerging adult (18-24 years) SMM. Data documenting burden and associated risk factors HIV adolescent SMM (<18 remain limited.Adolescent aged 13-18 years were recruited in 3 cities (Chicago, New York City, Philadelphia) interview testing. We used χ2 tests percentages binary variables 1-way analysis variance means continuous to assess...
We estimated lifetime risk and age-conditional of being diagnosed with HIV in 33 states name-based reporting.We used vital statistics data on general HIV-specific mortality, census data, surveillance to calculate cross-sectional, period-specific (2004-2005), age-specific probabilities an diagnosis. The were applied a hypothetical cohort 10 million live births, estimates derived for the risk, from birth, HIV.The was 1.87% males (95% confidence limit: 1.86 1.89) or 1 53 0.71% females...
We examined the association between socioeconomic position (SEP) and HIV diagnosis rates in United States whether racial/ethnic disparities persist after control for SEP.We used cases of infection among persons aged 13 years older, diagnosed 2005 through 2009 37 states reported to national surveillance June 2010, US Census data, examine associations county-level SEP measures 5-year average annual overall race/ethnicity-sex groups.The rate was significantly higher individuals low-SEP tertile...
Annual screening for syphilis is indicated all sexually active men who have sex with (MSM).Using National HIV Behavioral Surveillance data from 2008, 2011, and 2014, we assessed trends in self-reported testing diagnoses the past 12 months among MSM. We calculated percentages of diagnosis by selected characteristics each year. Trends were using Poisson regression models generalized estimation equations. Analysis was limited to participants reported screening.Analysis included 28,295 Overall,...
As annual influenza vaccination is recommended for all U.S. persons aged 6 months or older, it unethical to conduct randomized clinical trials estimate vaccine effectiveness (VE). Observational studies are being increasingly used VE. We developed a probability model comparing the bias and precision of VE estimates from two case-control designs: traditional (TCC) design test-negative (TN) design. In both study designs, acute respiratory illness (ARI) patients seeking medical care testing...
Autophagy is a cellular self-degrading process that plays key role in health and functioning. Since autophagy disorder related to many diseases, it highly important detect autophagy. This study aimed establish dual-sensing mechanism-based ratiometric viscosity-sensitive lysosome-targeted two-photon fluorescent probe Vis-sun track the (the increase lysosome viscosity during autophagy) by combining through bond energy transfer (TBET) aggregation-induced emission (AIE). The introduction of TBET...