A5040055432- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Immune responses and vaccinations
- Immunodeficiency and Autoimmune Disorders
- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- Zoonotic diseases and public health
- Monoclonal and Polyclonal Antibodies Research
- Mosquito-borne diseases and control
- Virus-based gene therapy research
- Biosensors and Analytical Detection
- Parvovirus B19 Infection Studies
- Transgenic Plants and Applications
- Advanced Biosensing Techniques and Applications
- Parasitic Diseases Research and Treatment
- Hepatitis B Virus Studies
- Infection Control and Ventilation
- Toxic Organic Pollutants Impact
CDC Foundation
2025
Centers for Disease Control and Prevention
2011-2025
National Center for Immunization and Respiratory Diseases
2021-2024
Louisiana State Department of Health and Hospitals
2021
Response Biomedical (Canada)
2020
University of Illinois Chicago
2006-2009
Ball State University
2004
We report the discovery and optimization of a potent inhibitor against papain-like protease (PLpro) from coronavirus that causes severe acute respiratory syndrome (SARS-CoV). This unique is not only responsible for processing viral polyprotein into its functional units but also capable cleaving ubiquitin ISG15 conjugates plays significant role in helping SARS-CoV evade human immune system. screened structurally diverse library 50,080 compounds inhibitors PLpro discovered noncovalent lead...
Health care personnel (HCP) caring for patients with coronavirus disease 2019 (COVID-19) might be at high risk contracting SARS-CoV-2, the virus that causes COVID-19. Understanding prevalence of and factors associated SARS-CoV-2 infection among frontline HCP who COVID-19 are important protecting both their patients. During April 3-June 19, 2020, serum specimens were collected from a convenience sample worked 13 geographically diverse academic medical centers in United States, tested...
Hui Zeng, MD; Chen Xu, BS; Junli Fan, Yueting Tang, PhD; Qiaoling Deng, Wei Zhang, MD, Xinghua Long, PhD
Most persons infected with SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), develop virus-specific antibodies within several weeks, but antibody titers might decline over time. Understanding timeline of is important for interpreting SARS-CoV-2 serology results. Serum specimens were collected from a convenience sample frontline health care personnel at 13 hospitals and tested to during April 3-June 19, 2020, again approximately 60 days later assess this timeline. The...
Changes in testing behaviors and reporting requirements have hampered the ability to estimate U.S. SARS-CoV-2 incidence (1). Hybrid immunity (immunity derived from both previous infection vaccination) has been reported provide better protection than that or vaccination alone (2). To of prevalence infection- vaccination-induced antibodies (or both), data a nationwide, longitudinal cohort blood donors were analyzed. During second quarter 2021 (April-June), an estimated 68.4% persons aged ≥16...
Immune sera from convalescent patients have been shown to be effective in the treatment of infected with Severe Acute Respiratory Syndrome Virus (SARS-CoV) making passive immune therapy human monoclonal antibodies an attractive strategy for SARS. Previously, using Xenomouse (Amgen British Columbia Inc), we produced a panel neutralizing Human (HmAbs) that could specifically bind ectodomain SARS-CoV spike (S) glycoprotein. Some HmAbs were S1 domain specific, while some not. In this study,...
We describe here the design, synthesis, molecular modeling, and biological evaluation of a series small molecule, nonpeptide inhibitors SARS-CoV PLpro. Our initial lead compound was identified via high-throughput screening diverse chemical library. subsequently carried out structure−activity relationship studies optimized structure to potent that have shown antiviral activity against infected Vero E6 cells. Upon basis X-ray crystal inhibitor 24-bound PLpro, drug design template created....
On April 21, 2022, CDC issued a health advisory† encouraging U.S. clinicians to report all patients aged <10 years with hepatitis of unknown etiology public authorities, after identification similar cases in both the United States (1) and Europe.§ A high proportion initially reported had adenovirus detected whole blood specimens, thus advisory encouraged consider requesting testing, preferentially on specimens. For meeting criteria (patients under investigation [PUIs]), jurisdictional...
Serological surveys provide an objective biological measure of population immunity, and tetanus serological can also assess vaccination coverage. We undertook a national assessment immunity to diphtheria among Nigerian children aged <15 years using stored specimens collected during the 2018 Nigeria HIV/AIDS Indicator Impact Survey, cross-sectional household-based survey. used validated multiplex bead assay test for toxoid-antibodies. In total, 31,456 were tested. Overall, 70.9% 84.3% had at...
To assess transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a detention facility experiencing disease outbreak and evaluate testing strategies, we conducted prospective cohort investigation Louisiana, USA. We SARS-CoV-2 for detained persons 6 quarantined dormitories at various time points. Of 143 persons, 53 were positive the initial test, an additional 58 later points (cumulative incidence 78%). In 1 dormitory, all 45 initially negative; 18 days later, 40 (89%)...
Rubella infection during pregnancy can result in miscarriage or infants with a constellation of birth defects known as congenital rubella syndrome (CRS). When coverage is inadequate, vaccination increase CRS cases by increasing the average age infection. Thus, World Health Organisation recommends that countries introducing vaccine be able to vaccinate at least 80% each cohort. Previous studies have focused on national-level analyses and overlooked sub-national variation introduction risk. We...
Nucleocapsid antibody assays can be used to estimate SARS-CoV-2 infection prevalence in regions implementing spike-based COVID-19 vaccines. However, poor sensitivity of nucleocapsid detecting after vaccination has been reported. We derived a lower cutoff for identifying previous infections large blood donor cohort (N = 142,599) by using the Ortho VITROS Anti-SARS-CoV-2 Total-N Antibody assay, improving while maintaining specificity >98%. validated samples donated self-reported swab-confirmed...
Abstract Background We assessed associations between binding antibody (bAb) concentration &lt;5 days from symptom onset and testing positive for COVID-19 among patients in a test-negative study. Methods From October 2021 to June 2022, study sites 7 states enrolled aged ≥6 months presenting with acute respiratory illness. Respiratory specimens were tested SARS-CoV-2. In blood specimens, we measured concentrations of anti-SARS-CoV-2 antibodies against the spike protein receptor domain...
Used motor oil is a common and toxic environmental contaminant, technologies for its remediation vary in success. The degradation of used soil as affected by plant treatment ("phytoremediation") was assessed growth chamber study. Seed germination several grass, legume, cereal species declined with an increase concentration; at rates greater than 1.0% (w/w), decreases most were significantly (p < 0.05) below control rates. Green beans (Phaseolus vulgaris), soybeans (Glycine max), maize (Zea...
More than 85% of US adults had been infected with SARS-CoV-2 by the end 2023. Continued serosurveillance transmission and assessments correlates protection require robust detection reinfections. We developed a serologic method for identifying reinfections in longitudinal blood donor data assessing nucleocapsid (N) antibody boosting using total immunoglobulin assay. Receiver operating characteristic curve analysis yielded an optimal ratio >1.43 (sensitivity 87.1%, specificity 96.0%). When...
Systematize the experience and identify challenges lessons learned in implementation of an initiative for integrated serosurveillance communicable diseases using a multiplex bead assay countries Americas.Documents produced were compiled reviewed. These included concept notes, internal working papers, regional meetings reports, survey protocols from three participating (Mexico, Paraguay, Brazil) two additional (Guyana Guatemala) where serology several was neglected tropical surveys....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into numerous lineages with unique spike mutations and caused multiple epidemics domestically globally. Although COVID-19 vaccines are available, new variants the capacity for immune evasion continue to emerge. To understand characterize evolution of circulating SARS-CoV-2 in U.S., Centers Disease Control Prevention (CDC) initiated National Strain Surveillance (NS3) program received thousands clinical specimens from...
Abstract Background Acute bronchiolitis due to respiratory syncytial virus (RSV) is the leading cause of hospitalizations in infants United States. Most available data on RSV epidemiology were obtained from hospital cohorts or medically attended illnesses, focusing symptomatic children. We examined PREVAIL Cohort (2017–2020) healthy, term Cincinnati, Ohio understand infections a birth cohort under weekly surveillance. Table 1 Medical attendance by age group, Cohort, Ohio, 2017–2020 Methods...