Jennifer L. Harcourt
A5037099923- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- Neonatal Respiratory Health Research
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- Animal Behavior and Reproduction
- Amphibian and Reptile Biology
- Infection Control and Ventilation
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- COVID-19 diagnosis using AI
- Fish Ecology and Management Studies
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 and Mental Health
- Animal Vocal Communication and Behavior
- RNA regulation and disease
- Immunodeficiency and Autoimmune Disorders
- vaccines and immunoinformatics approaches
- COVID-19 and healthcare impacts
- COVID-19 impact on air quality
- Virus-based gene therapy research
Centers for Disease Control and Prevention
2016-2025
Centers for Disease Control and Prevention
2025
National Center for Immunization and Respiratory Diseases
2016-2025
Marshfield Clinic
2022
Oshkosh (United States)
2022
University of Wisconsin–Oshkosh
2022
Louisiana State Department of Health and Hospitals
2021
The University of Texas Medical Branch at Galveston
2021
Oak Ridge Associated Universities
2021
Oak Ridge Institute for Science and Education
2021
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can spread rapidly within skilled nursing facilities. After identification of a case Covid-19 in facility, we assessed transmission and evaluated the adequacy symptom-based screening to identify infections residents.MethodsWe conducted two serial point-prevalence surveys, 1 week apart, which assenting residents facility underwent nasopharyngeal oropharyngeal testing for SARS-CoV-2, including real-time...
Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, causative agent of COVID-19. Here, we show that ribonucleoside analog β-d-N
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the etiologic agent associated with disease, which emerged in late 2019. In response, we developed a diagnostic panel consisting of 3 real-time reverse transcription PCR assays targeting nucleocapsid gene and evaluated use these for detecting SARS-CoV-2 infection. All demonstrated linear dynamic range 8 orders magnitude an analytical limit detection 5 copies/reaction quantified RNA transcripts 1 x 10-1.5 50%...
Abstract The etiologic agent of an outbreak pneumonia in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 January 2020. A patient the United States given a diagnosis infection with this virus by state Washington and US Centers for Disease Control Prevention on 20, We isolated from nasopharyngeal oropharyngeal specimens characterized viral sequence, replication properties, cell culture tropism. found that replicates to high titer Vero-CCL81 cells Vero E6 absence...
To the Editor A novel human coronavirus, now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, referred to as HCoV-19 here) that emerged in Wuhan, China late 2019 is causing a pandemic 1 . Here, we analyze aerosol and surface stability of compare it with SARS-CoV-1, most closely related coronavirus. We evaluated SARS-CoV-1 aerosols on different surfaces estimated their decay rates using Bayesian regression model (see Supplementary Appendix). All experimental measurements are...
In April 2012, the Jordan Ministry of Health investigated an outbreak lower respiratory illnesses at a hospital in Jordan; 2 fatal cases were retrospectively confirmed by real-time reverse transcription polymerase chain reaction (rRT-PCR) to be first detected Middle East syndrome (MERS-CoV).
Antigen-based tests for SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), are inexpensive and can return results within 15 minutes (1). Antigen have received Food Drug Administration (FDA) Emergency Use Authorization (EUA) use in asymptomatic symptomatic persons first 5-12 days after symptom onset (2). These been used at U.S. colleges universities other congregate settings (e.g., nursing homes correctional detention facilities), where serial testing of might facilitate...
Rapid antigen tests, such as the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW), offer results more rapidly (approximately 15-30 minutes) and at a lower cost than do highly sensitive nucleic acid amplification tests (NAATs) (1). have received Food Drug Administration (FDA) Emergency Use Authorization (EUA) for use in symptomatic persons (2), but data are lacking on test performance asymptomatic to inform expanded screening testing identify isolate infected (3). To evaluate of rapid test, it was...
To determine how long antibodies against Middle East respiratory syndrome coronavirus persist, we measured long-term antibody responses among persons serologically positive or indeterminate after a 2012 outbreak in Jordan. Antibodies, including neutralizing antibodies, were detectable 6 (86%) of 7 for at least 34 months the outbreak.
ABSTRACT The etiologic agent of the outbreak pneumonia in Wuhan China was identified as severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) January, 2020. first US patient diagnosed by State Washington and Centers for Disease Control Prevention on January 20, We isolated virus from nasopharyngeal oropharyngeal specimens, characterized viral sequence, replication properties, cell culture tropism. found that replicates to high titer Vero-CCL81 cells Vero E6 absence trypsin....
Importance As self-collected home antigen tests become widely available, a better understanding of their performance during the course SARS-CoV-2 infection is needed. Objective To evaluate diagnostic compared with reverse transcription–polymerase chain reaction (RT-PCR) and viral culture by days from illness onset, as well user acceptability. Design, Setting, Participants This prospective cohort study was conducted January to May 2021 in San Diego County, California, metropolitan Denver,...
BackgroundProlonged SARS-CoV-2 infections in people who are immunocompromised might predict or source the emergence of highly mutated variants. The types immunosuppression placing patients at highest risk for prolonged infection have not been systematically investigated. We aimed to assess factors and associated intrahost evolution.MethodsIn this multicentre, prospective analysis, participants were enrolled five US medical centres. Eligible aged 18 years older, SARS-CoV-2-positive previous...
† Symptoms of Zika virus disease include acute onset fever, maculopapular rash, arthralgia, or conjunctivitis.§ Persons with ongoing possible exposure those who reside in frequently travel (e.g., daily weekly) to an area risk for transmission.¶ For the purposes this guidance, recent virus/flavivirus infection is defined as a during current pregnancy periconceptional period (i.e., 8 weeks before conception 6 last menstrual period).
Abstract Introduction More than 93,000 cases of coronavirus disease (COVID-19) have been reported worldwide. We describe the epidemiology, clinical course, and virologic characteristics first 12 U.S. patients with COVID-19. Methods collected demographic, exposure, information from confirmed by CDC during January 20–February 5, 2020 to Respiratory, stool, serum, urine specimens were submitted for SARS-CoV-2 rRT-PCR testing, virus culture, whole genome sequencing. Results Among patients,...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes disease 2019 (COVID-19), was first identified in Wuhan, China, December 2019, with subsequent worldwide spread. The US cases were January 2020. Methods To determine if SARS-CoV-2–reactive antibodies present sera prior to case United States on 19 2020, residual archived samples from 7389 routine blood donations collected by American Red Cross 13 17 2020 donors resident 9 states (California,...
Incarcerated populations have experienced disproportionately higher rates of COVID-19-related illness and death compared with the general U.S. population, due in part to congregate living environments that can facilitate rapid transmission SARS-CoV-2, virus causes COVID-19, high prevalence underlying medical conditions associated severe COVID-19 (1,2). The SARS-CoV-2 B.1.617.2 (Delta) variant has caused outbreaks among vaccinated unvaccinated persons settings large public gatherings (3,4)....
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence new variant lineages that have exacerbated COVID-19 pandemic. Some those variants were designated as concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact vaccine-mediated protection from disease. To ascertain and rank risk VOCs VOIs, we analyze ability 14 (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta,...
Interactions between fractalkine (CX3CL1) and its receptor, CX3CR1, mediate leukocyte adhesion, activation, trafficking. The respiratory syncytial virus (RSV) G protein has a CX3C chemokine motif that can bind CX3CR1 modify CXCL1-mediated responses. In this study, we show expression of the RSV or during infection is associated with reduced CX3CR1+ T cell trafficking to lung, frequencies RSV-specific, MHC class I-restricted IFN-gamma-expressing cells, lower numbers IL-4- CX3CL1-expressing...
Because the G protein of respiratory syncytial virus (RSV) has a CX3C chemokine motif that been associated with ability RSV to modulate virus-induced host immune response, we examined whether therapeutic treatment an anti-RSV monoclonal antibody (mAb), 131-2G, blocks CX3C-associated activity might decrease pulmonary inflammation infection in BALB/c mice. The results show mAb 131-2G on day 3 after reduces both and titer lungs. Later administration (day 5 infection) effectively reduced viral...
ABSTRACT Respiratory syncytial virus (RSV) infection causes substantial morbidity and some deaths in the young elderly worldwide. There is no safe effective vaccine available, although it possible to reduce hospitalization rate for high-risk children by anti-RSV antibody prophylaxis. RSV has been shown modify immune response infection, a feature linked part G protein CX3C chemokine mimicry. This study determined if vaccination with polypeptides or peptides spanning central conserved region...
Abstract Background Real-time reverse transcription polymerase chain reaction (rRT-PCR) and antigen tests are important diagnostics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sensitivity of has been shown to be lower than that rRT-PCR; however, data evaluate epidemiologic characteristics affect test performance limited. Methods Paired mid-turbinate nasal swabs were collected from university students staff tested SARS-CoV-2 using both Quidel Sofia SARS Antigen...
SARS-CoV-2 transmission from contaminated surfaces, or fomites, has been a concern during the COVID-19 pandemic. Households have important sites of throughout pandemic, but there is limited information on contamination surfaces in these settings. We describe environmental detection households persons with to better characterize potential risks fomite transmission. Ten ≥1 person laboratory-confirmed and ≥2 members total were enrolled Utah, U.S.A. Nasopharyngeal anterior nasal swabs collected...