A5009540061- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- SARS-CoV-2 detection and testing
- vaccines and immunoinformatics approaches
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- COVID-19 Impact on Reproduction
- Animal Virus Infections Studies
Centers for Disease Control and Prevention
2021-2024
National Center for Immunization and Respiratory Diseases
2022-2024
Battelle
2021
The University of Texas Medical Branch at Galveston
2021
Oak Ridge Associated Universities
2021
Oak Ridge Institute for Science and Education
2021
Leidos (United States)
2021
Before the emergence of SARS-CoV-2, virus that causes COVID-19, influenza activity in United States typically began to increase fall and peaked February. During 2021-22 season, November remained elevated until mid-June, featuring two distinct waves, with A(H3N2) viruses predominating for entire season. This report summarizes during October 3, 2021-June 11, 2022, describes composition Northern Hemisphere 2022-23 vaccine. Although is decreasing circulation summer low, remaining vigilant...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019, and the outbreak rapidly evolved into current disease pandemic. SARS-CoV-2 is a virus that causes symptoms similar to those caused by influenza A B viruses. On July 2, 2020, US Food Drug Administration granted emergency use authorization for vitro diagnostic of Influenza Multiplex Assay. This assay detects at 102.0, 102.2, 100.3 50% tissue culture or egg infectious dose, as few 5 RNA copies/reaction....
Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses has been reported. We evaluated cell lines commonly used to isolate diagnose related diseases for their susceptibility SARS-CoV-2. Although multiple kidney from monkeys were susceptible SARS-CoV-2, we found many types derived humans, dogs, minks, cats, mice, chicken not. analyzed MDCK cells, which are most surveillance study of influenza viruses, that they not The low expression level the...
The global spread of the highly pathogenic avian influenza (HPAI) A(H5N1) virus poses a serious pandemic threat, necessitating swift development effective vaccines. success messenger RNA (mRNA) vaccine technology in COVID-19 pandemic, marked by its rapid and scalability, demonstrates potential for addressing other infectious threats, such as HPAI A(H5N1). We therefore evaluated mRNA candidates targeting panzootic A(H5) clade 2.3.4.4b viruses, which have been shown to infect range mammalian...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into numerous lineages with unique spike mutations and caused multiple epidemics domestically globally. Although COVID-19 vaccines are available, new variants the capacity for immune evasion continue to emerge. To understand characterize evolution of circulating SARS-CoV-2 in U.S., Centers Disease Control Prevention (CDC) initiated National Strain Surveillance (NS3) program received thousands clinical specimens from...
Swine harbors a genetically diverse population of swine influenza A viruses (IAV-S), with demonstrated potential to transmit the human population, causing outbreaks and pandemics. Here, we describe development one-step, triplex real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay that detects distinguishes majority antigenically distinct virus hemagglutinin (HA) clades currently circulating in North American swine, including IAV-S H1 1A.1 (α), 1A.2 (β), 1A.3 (γ), 1B.2.2...
Abstract Coinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses is inevitable as the COVID-19 pandemic continues. This study aimed to evaluate cell lines commonly used in virus diagnosis isolation for their susceptibility SARS-CoV-2. While multiple kidney from monkeys were susceptible permissive SARS-CoV-2, many types derived human, dog, mink, cat, mouse, or chicken not. Analysis of MDCK cells, which are most surveillance influenza viruses,...
Abstract The SARS-CoV-2 spike protein is a highly immunogenic and mutable that the target of vaccine prevention antibody therapeutics. This makes encoding S-gene an important sequencing target. community overwhelmingly adopted tiling amplicon-based strategies for entire genome. As virus evolved, primer mismatches inevitably led to amplicon drop-out. Given exposure host antibodies, mutation occurred here most rapidly, leading failure over insightful region To mitigate this, we developed...
The COVID-19 pandemic was accompanied by an unprecedented surveillance effort. resulting data were and will continue to be critical for control of SARS-CoV-2. However, some genomic methods experienced challenges as the virus evolved, in incomplete poor quality data. Complete coverage, especially S-gene, is important supporting selection vaccine candidates. As such, we developed a robust method target S-gene amplification sequencing. By focusing on imposing strict coverage metrics, hope...