A5059734466- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Probiotics and Fermented Foods
- Muscle Physiology and Disorders
- vaccines and immunoinformatics approaches
- RNA modifications and cancer
- Viral Infections and Outbreaks Research
- Bacteriophages and microbial interactions
- Smoking Behavior and Cessation
- Genomics and Rare Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Nicotinic Acetylcholine Receptors Study
- Indoor Air Quality and Microbial Exposure
- Genomic variations and chromosomal abnormalities
- Vaccine Coverage and Hesitancy
- Enterobacteriaceae and Cronobacter Research
- COVID-19 epidemiological studies
- Blood groups and transfusion
- Plant-Microbe Interactions and Immunity
- Microbial Community Ecology and Physiology
- CRISPR and Genetic Engineering
Centers for Disease Control and Prevention
2008-2025
National Center for Immunization and Respiratory Diseases
2023
Analytical Services
2016-2022
Battelle
2016-2022
Centers for Disease Control and Prevention
2021
Vanderbilt University Medical Center
2020
Johnson & Johnson (United States)
2020
University of Michigan
2020
University of Pittsburgh
2020
The Centers
2016
In the United States, annual vaccination against seasonal influenza is recommended for all persons aged ≥6 months. Each season since 2004-05, CDC has estimated effectiveness of vaccine to prevent influenza-associated, medically attended acute respiratory illness (ARI). This report uses data from 2,319 children and adults enrolled in U.S. Influenza Vaccine Effectiveness (Flu VE) Network during December 2, 2013-January 23, 2014, estimate an interim adjusted preventing laboratory-confirmed...
The 2023-24 U.S. influenza season was characterized by a predominance of A(H1N1)pdm09 virus circulation with co-circulation A(H3N2) and B/Victoria viruses. We estimated vaccine effectiveness (VE) in the United States against mild-to-moderate medically attended illness season. enrolled outpatients aged ≥8 months acute respiratory 7 states. Respiratory specimens were tested for type/subtype reverse-transcriptase polymerase chain reaction (RT-PCR). Influenza VE test-negative design comparing...
The congenital muscular dystrophies (CMDs) comprise a heterogeneous group of heritable muscle disorders with often difficult to interpret pathology, making them challenging diagnose. Serial Sanger sequencing suspected CMD genes, while the current molecular diagnostic method choice, can be slow and expensive. A comprehensive panel test for simultaneous screening mutations in all known CMD-associated genes would more effective strategy. Thus, CMDs are model disorder development validation...
The bacterial communities present in smokeless tobacco (ST) products have not previously reported. In this study, we used Next Generation Sequencing to study the bacteria U.S.-made dry snuff, moist snuff and Sudanese toombak. Sample diversity taxonomic abundances were investigated these products. A total of 33 families from four phyla, Actinobacteria, Firmicutes, Proteobacteria Bacteroidetes, identified. U.S.-produced contained a diverse distribution all phyla. Moist dominated by Firmicutes....
To provide researchers an extensive characterization of the SPECTRUM variable nicotine research cigarettes.Data on cigarette physical properties, content, harmful and potentially constituents in tobacco filler was compiled.Data concentrations menthol, minor alkaloids, tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons, ammonia, toxic metals for all available varieties Spectrum cigarettes are provided. The similarity chemistry properties to commercial renders them acceptable use...
Predominance of 2 antigenically drifted influenza viruses during the 2019-2020 season offered an opportunity to assess vaccine effectiveness against life-threatening pediatric disease from vaccine-mismatched in United States.We enrolled children aged <18 years admitted intensive care unit with acute respiratory infection across 17 hospitals. Respiratory specimens were tested using reverse-transcription polymerase chain reaction for and sequenced. Using a test-negative design, we estimated...
Sequencing individual genes by Sanger sequencing is a time-consuming and costly approach to resolve clinically heterogeneous genetic disorders. Panel testing offers the ability efficiently cost-effectively screen all of for particular disorder. We assessed analytical sensitivity specificity two different enrichment technologies, solution-based hybridization microdroplet-based PCR target enrichment, in conjunction with next-generation (NGS), identify mutations 321 exons representing 12...
Abstract Background Influenza causes significant morbidity and mortality stresses hospital resources during periods of increased circulation. We evaluated the effectiveness 2019–2020 influenza vaccine against influenza-associated hospitalization in United States. Methods included adults hospitalized with acute respiratory illness at 14 hospitals tested for viruses by reserve-transcription polymerase chain reaction. Vaccine (VE) was estimated comparing odds current-season vaccination...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into numerous lineages with unique spike mutations and caused multiple epidemics domestically globally. Although COVID-19 vaccines are available, new variants the capacity for immune evasion continue to emerge. To understand characterize evolution of circulating SARS-CoV-2 in U.S., Centers Disease Control Prevention (CDC) initiated National Strain Surveillance (NS3) program received thousands clinical specimens from...
We estimated vaccine effectiveness (VE) for prevention of influenza-associated hospitalizations among adults during the 2018-2019 influenza season. Adults admitted with acute respiratory illness to 14 hospitals US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN) and testing positive were cases; patients negative controls. VE was using logistic regression inverse probability treatment weighting. analyzed data from 2863 a mean age 63 years. Adjusted against...
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder and affects approximately 1 in 15,000 births the United States. CAH one of disorders included on Newborn Screening (NBS) Recommended Uniform Panel. The commonly used immunological NBS test associated with a high false positive rate there interest developing second-tier assays to increase screening specificity. Approximately 90% classic forms CAH, salt-wasting simple virilizing, are due mutations CYP21A2 gene. These...
Abstract Smokeless tobacco (ST) products are used worldwide and a major public health concern. In addition to harmful chemicals found in these products, microbes ST believed be responsible for generating tobacco-specific nitrosamines (TSNAs), the most abundant carcinogens ST. These also contribute endotoxins other pro-inflammatory components. A greater understanding of microbial constituents is sought order potentially link select design aspects or manufacturing processes avoidable increases...
Smokeless tobacco (ST) products are widely used throughout the world and contribute to morbidity mortality in users through an increased risk of cancers oral diseases. Bacterial populations ST taste, but their presence can also create carcinogenic, Tobacco-Specific N-nitrosamines (TSNAs). Previous studies microbial communities lacked chemistry data (e.g. nicotine, TSNAs) characterize identify associations between carcinogen levels taxonomic groups. This study uses statistical analysis...
The 2023-24 U.S. influenza season was characterized by a predominance of A(H1N1)pdm09 virus circulation with co-circulation A(H3N2) and B/Victoria viruses. We estimated vaccine effectiveness (VE) in the United States against mild-to-moderate medically attended illness season.
Abstract The SARS-CoV-2 spike protein is a highly immunogenic and mutable that the target of vaccine prevention antibody therapeutics. This makes encoding S-gene an important sequencing target. community overwhelmingly adopted tiling amplicon-based strategies for entire genome. As virus evolved, primer mismatches inevitably led to amplicon drop-out. Given exposure host antibodies, mutation occurred here most rapidly, leading failure over insightful region To mitigate this, we developed...
The COVID-19 pandemic was accompanied by an unprecedented surveillance effort. resulting data were and will continue to be critical for control of SARS-CoV-2. However, some genomic methods experienced challenges as the virus evolved, in incomplete poor quality data. Complete coverage, especially S-gene, is important supporting selection vaccine candidates. As such, we developed a robust method target S-gene amplification sequencing. By focusing on imposing strict coverage metrics, hope...