A5079354701- Influenza Virus Research Studies
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Cystic Fibrosis Research Advances
- Receptor Mechanisms and Signaling
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Energy Harvesting in Wireless Networks
- Flavonoids in Medical Research
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Pharmacological Receptor Mechanisms and Effects
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Infection Control and Ventilation
- Tracheal and airway disorders
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Mycobacterium research and diagnosis
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
University of Illinois Chicago
2020-2025
The University of Texas Health Science Center at Houston
2020
There is a strong rationale to consider future cell therapeutic approaches for cystic fibrosis (CF) in which autologous proximal airway basal stem cells, corrected CFTR mutations, are transplanted into the patient's lungs. We assessed possibility of editing locus these cells using zinc-finger nucleases and have pursued two approaches. The first, mutation-specific correction, footprint-free method replacing mutation with sequences. applied this approach correction ΔF508, demonstrating...
Hepatitis B virus (HBV) is a worldwide health problem without curative treatments. Investigation of the regulation HBV biosynthesis by class I and II histone deacetylases (HDACs) demonstrated that catalytically active HDAC5 upregulates biosynthesis. expression increased both stability splicing 3.5 kb RNA altering translational efficiency viral pregenomic or spliced 2.2 RNAs. Together, these observations point to broader role in regulating transcript while specifically identifying potentially...
Influenza A virus (IAV) poses a global public health concern and remains an imminent threat to human health. Emerging antiviral resistance the currently approved influenza drugs emphasizes urgent need for new therapeutic entities against IAV. Allopregnanolone (ALLO) is natural product that has been as antidepressant drug. In present study, we repurposed ALLO novel inhibitor IAVs. Mechanistic studies demonstrated inhibited replication by interfering with nucleus translocation of viral...
The recent COVID-19 pandemic has underscored the danger of airborne viral pathogens. lack model systems to study pathogens limits understanding pathogen distribution as well potential surveillance and mitigation strategies. In this work, we develop a novel system using virus-like particles (VLPs). Specifically, demonstrate ability aerosolize VLP detect quantify aerosolized RNA by reverse transcription-loop-mediated isothermal amplification in real-time fluorescent colorimetric assays....
Ethnopharmacological relevance: Qingjin Huatan Decoction (QJHTT) consists of 11 herbal medicines: Scutellaria baicalensis Georgi, Gardenia jasminoides J.Ellis, Platycodon grandiflorus (Jacq.) A.DC., Ophiopogon japonicus (Thunb.) Ker Gawl., Morus alba L., Fritillaria thunbergii Miq., Anemarrhena asphodeloides Bunge, Trichosanthes kirilowii Maxim., Citrus reticulata Blanco, Poria cocos (Schw.) Wolf, and Glycyrrhiza uralensis Fisch. As a traditional compound Chinese medicinal formula, QJHTT has...
Influenza A viruses (IAVs) have gradually developed resistance to FDA-approved drugs, which increases the need discover novel antivirals with new mechanisms of action. Here, we used a phenotypic screening strategy and discovered that imidazo[1,2-a]pyrazine derivative A4 demonstrates potent broad-spectrum anti-influenza activity, especially for oseltamivir-resistant H1N1/pdm09 strain. Indirect immunofluorescence assays revealed induces clustering viral nucleoprotein (NP) prevents its nuclear...