A5017265118- Neuroscience and Neuropharmacology Research
- Parasites and Host Interactions
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- RNA modifications and cancer
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- T-cell and B-cell Immunology
- Nicotinic Acetylcholine Receptors Study
- RNA Research and Splicing
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Suicide and Self-Harm Studies
- RNA regulation and disease
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Neural dynamics and brain function
- Advanced Electron Microscopy Techniques and Applications
- Research on Leishmaniasis Studies
- Cancer-related molecular mechanisms research
- Helminth infection and control
- Malaria Research and Control
University of Missouri
2025
University of Utah
2012-2024
Walton County School District
2016
University of California, San Diego
2010-2011
Human BioMolecular Research Institute
2007
Sanford Burnham Prebys Medical Discovery Institute
2007
University of California, Santa Cruz
2003-2006
National Institute of Allergy and Infectious Diseases
1993-1998
National Institutes of Health
1991-1998
Harvard University
1991-1992
Abstract Increasing evidence suggests that schistosome egg granulomas are primarily Th2 cellular reactions. Mice infected with Schistosoma mansoni were treated a neutralizing mAb against IL-4 to evaluate the role of this cytokine in generation parasite egg-induced cell-mediated responses and hepatic pathology. Animals anti-IL-4 before deposition showed decreased IL-4, IL-5, IL-10 production response vitro antigenic stimulations IL-5 IL-13 mRNA levels liver. As observed previously, non-B,...
Sensory loss is prevalent in older adults and associated with changes to brain structure function. In early life, the compensates for sensory by upregulating intact senses, such as deafness where neural sensitivity vision increases visual peripheral perception improves. However, it unclear if similar neuroplastic compensation occurs loss, which would show aging brain’s adaptability inform rehabilitation strategies. We tested evidence of compensatory neuroplasticity (N = 66) aged 53 80...
Abstract We have used IL-10 gene knockout mice (IL-10T) to examine the role of endogenous in down-modulation hepatic granuloma formation and lymphocyte responses that occurs chronic infection with helminth parasite Schistosoma mansoni. Although IL-10-deficient animals showed 20 30% mortality between 8 14 wk postinfection, they displayed no alterations their susceptibility produced similar numbers eggs as wild-type littermates. The IL-10T a significant increase size at acute stage infection,...
Synaptic target specificity, whereby neurons make distinct types of synapses with different cells, is critical for brain function, yet the mechanisms driving it are poorly understood. In this study, we demonstrate Kirrel3 regulates target-specific synapse formation at hippocampal mossy fiber (MF) synapses, which connect dentate granule (DG) to both CA3 and GABAergic neurons. Here, show required MF filopodia; structures that give rise DG-GABA regulate feed-forward inhibition Consequently,...
The UNC5Hs are axon guidance receptors that mediate netrin-1-dependent chemorepulsion, and dependence netrin-1-independent apoptosis. Here, we report an interaction between UNC5H1 NRAGE. Our experiments show this is responsible for apoptosis induced by UNC5H1, level of greater than the amount either UNC5H2 or UNC5H3. We mapped NRAGE binding domain to its ZU-5 region, in addition adjacent PEST sequence, required UNC5H1-mediated Chimeric UNC5H3 receptors, containing sequence bind cause...
Culture of murine T cells with immobilized (platebound) anti-CD3 antibody results in autocrine growth factor secretion both Th1 (IL-2 producing) and Th2 (IL-4 cells. Using a panel cell clones, we demonstrate that the IL-2-induced proliferation clones is dramatically inhibited by antibody, whereas not. This unresponsiveness to IL-2 not due decreases IL-2R expression. Supernatants from or cultures fail alter effects on two types suggesting induced lack thereof mediated stable cytokine(s)....
Abstract Suicide is the 10th leading cause of death in United States. Although environment has undeniable impact, evidence suggests that genetic factors play a significant role completed suicide. We linked resource ~ 4500 DNA samples from suicides obtained Utah Medical Examiner to genealogical records and medical data available on over eight million individuals. This linking resulted identification high-risk extended families (7–9 generations) with familial risk Familial aggregation across...
Cytokine responses of peripheral blood mononuclear cells from humans infected with Schistosoma mansoni were assessed. By ELISA and ELISPOT, persons acute hepatosplenic infections produced higher levels interleukin (IL)-4 IL-5 frequencies IL-4-producing in response to mitogen than did uninfected persons. In contrast, mitogen-induced production the Th1 cytokine interferon-ã (lFN-ã) not differ that controls. Upon stimulation egg antigens, many patients responded elevated IL-4 mRNA but displayed...
Netrin-1 is a bifunctional guidance cue that directs migrating neurons and axons based on specific receptors expressed the cell surface. Attraction occurs through receptor Deleted in Colorectal Cancer (DCC) repulsion complex of DCC UNC5H, vertebrate homolog to Caenorhabditis elegans UNC-5, but how surface expression these achieved remains unknown. Here, we demonstrate UNC5H1 regulated by protein interacting with C kinase-1 (PICK1) kinase (PKC), show one mechanism which cells control their...
The goal of these studies was to define the stimuli and factors that control induction anergy in unimmunized resting T lymphocytes. Initial experiments, aimed at establishing system, showed exposure Th1 but not Th2 clones immobilized anti-CD3 leads a block autocrine growth factor production proliferation upon subsequent restimulation with Ag+APC. Anergy is prevented by accessory cells, suggesting this model cell tolerance may be due receptor-mediated inhibitory signals, independent...
Acyl-CoA-binding protein (ACBP) functions both intracellularly as part of fatty acid metabolism and extracellularly diazepam binding inhibitor, the precursor endozepine peptides. Two these peptides, ODN TTN, bind to GABA(A) receptor modulate its sensitivity gamma-aminobutyric (GABA). We have found that depolarization mouse primary astrocytes induces rapid release processing ACBP active previously showed can trigger sporulation social amoeba Dictyostelium. Using this bioassay, we now show...
The establishment of neuronal circuits relies on the stabilization functionally appropriate connections and elimination inappropriate ones. Here we report that postsynaptic AMPA receptors play a critical role in regulating stability glutamatergic synapses. Removal surface leads to decrease number excitatory presynaptic inputs, whereas overexpression increases synapse stability. Furthermore, along with Neuroligin-1 293T cells is sufficient stabilize inputs from cortical neurons onto...
BACKGROUND Head lice is a common condition in school-age children caused by Pediculus humanus capitis. Although typically associated with scalp itching and discomfort, chronic or severe infestations can occasionally lead to more health consequences. This report describes 12-year-old boy from Missouri, USA, presenting iron deficiency anemia (IDA) head infestation. IDA characterized insufficient meet the body's needs, due blood loss, nutritional deficiencies, malabsorption. While there no...
When cultured in vitro with either mitogen or parasite antigens, spleen cells from mice infected Schistosoma mansoni produce significantly higher levels of IL-4 than splenocytes control animals. Previous studies suggested that this increase production occurs because a selective expansion T helper type 2 (Th2) mice. However, these experiments employed unfractionated populations rather purified lymphocytes. Here we demonstrate T-depleted animals synthesize high interleukin-4 (IL-4), but no...
Neural circuits balance excitatory and inhibitory activity disruptions in this are commonly found neurodevelopmental disorders. Mice lacking the intellectual disability autism-associated gene Kirrel3 have an excitation-inhibition imbalance hippocampus but precise synaptic changes underlying functional defect unknown. is a homophilic adhesion molecule expressed dentate gyrus (DG) GABA neurons. It was suggested that of hippocampal neurons knockout mice due to loss mossy fiber (MF) filopodia,...
C57BL/6 mice immunized intradermally (i.d.) with bacillus Calmette Guerin (BCG) plus killed skin-stage schistosomula are protected against subsequent infection Schistosoma mansoni, whereas immunization by i.v. or i.m. routes is not protective. Moreover, previous via the nonprotective route interfered ability to subsequently induce protection i.d. vaccination, suggesting that inhibitory responses invoked. Given evidence activated macrophages (M phi) play a role as effector cells in...