A5041908130- Marine animal studies overview
- Animal Vocal Communication and Behavior
- Primate Behavior and Ecology
- Indigenous Studies and Ecology
- Animal Behavior and Reproduction
- Wildlife Ecology and Conservation
- Evolutionary Game Theory and Cooperation
- Child and Animal Learning Development
- Language and cultural evolution
- Single-cell and spatial transcriptomics
- Memory and Neural Mechanisms
- Cancer Genomics and Diagnostics
- Plant and animal studies
- CRISPR and Genetic Engineering
- Cell Image Analysis Techniques
- Animal Ecology and Behavior Studies
- Animal Behavior and Welfare Studies
- Cognitive Science and Mapping
- Bat Biology and Ecology Studies
- RNA Interference and Gene Delivery
- Cephalopods and Marine Biology
- Marine and fisheries research
- Breast Cancer Treatment Studies
- Human-Animal Interaction Studies
- Advanced Fluorescence Microscopy Techniques
University of Konstanz
2019-2024
University of California, Davis
2024
Max Planck Institute of Animal Behavior
2019-2024
University of Leeds
2018-2022
Cancer Research UK Cambridge Center
2021
IIT@MIT
2021
McGovern Institute for Brain Research
2021
Engineering Arts (United States)
2021
Allen Institute
2021
Howard Hughes Medical Institute
2021
Abstract A holistic understanding of tissue and organ structure function requires the detection molecular constituents in their original three-dimensional (3D) context. Imaging mass cytometry (IMC) enables simultaneous up to 40 antigens transcripts using metal-tagged antibodies but has so far been restricted two-dimensional imaging. Here we report development 3D IMC for multiplexed analysis at single-cell resolution demonstrate utility technology by human breast cancer samples. The resulting...
Birds in the bin It is by now well accepted that humans are not only animal to have complex culture, and we also found ecological novelty can lead cultural innovation. Klump et al. documented emergence of an evolving set behaviors response human-generated resources, specifically garbage bins, sulphur-crested cockatoos. This finding both documents existence spread foraging culture among parrots, a lineage known for high-level cognitive function, illuminates how innovation regional distinct...
Abstract Male alliances are an intriguing phenomenon in the context of reproduction since, most taxa, males compete over indivisible resource, female fertilization. Adult male bottlenose dolphins (Tursiops aduncus) Shark Bay, Western Australia, form long-term, multilevel to sequester estrus females. These therefore critical reproductive success. Yet, long-term processes leading formation such complex social bonds still poorly understood. To identify criteria by which with other males, we...
The heterogeneity of breast cancer plays a major role in drug response and resistance has been extensively characterized at the genomic level. Here, single-cell mass cytometry (BCMC) panel is optimized to identify cell phenotypes their oncogenic signalling states biobank patient-derived tumour xenograft (PDTX) models representing diversity human cancer. BCMC identifies 13 cellular (11 2 murine), associated with both subtypes specific features. Pre-treatment phenotypic composition determinant...
Behavioural differences among social groups can arise from differing ecological conditions, genetic predispositions and/or learning. In the past, learning has typically been inferred as responsible for spread of behaviour by exclusion and factors. This 'method exclusion' was used to infer that 'sponging', a foraging involving tool use in bottlenose dolphin (Tursiops aduncus) population Shark Bay, Western Australia, socially transmitted. However, previous studies were limited they never fully...
Abstract Investigations into cooperative partner choice should consider both potential and realised partners, allowing for the comparison of traits across all those available. Male bottlenose dolphins form persisting multi-level alliances. Second-order alliances 4–14 males are core social unit, within which 2–3 first-order to sequester females during consortships. We compared bond strength, relatedness age similarity partners individual in two periods: (i) adolescence, when second-order...
Recent well-documented cases of cultural evolution towards increasing efficiency in non-human animals have led some authors to propose that other are also capable cumulative evolution, where traits become more refined and/or complex over time. Yet few comparative examples exist complexity, and experimental tests remain scarce. In a previous study, we introduced foraging innovation into replicate subpopulations great tits, the 'sliding-door puzzle'. Here, track diffusion second 'dial puzzle',...
Homophilous behaviour plays a central role in the formation of human friendships. Individuals form social ties with others that show similar phenotypic traits, independently relatedness. Evidence such homophily can be found bottlenose dolphins ( Tursiops aduncus) Shark Bay, Western Australia, where females use marine sponges as foraging tools often associate other sponges. 'Sponging' is socially learned, time-consuming behaviour, transmitted from mother to calf. Previous research illustrated...
Sociality impacts many biological processes and can be tightly linked to an individual's fitness. To maximize the advantages of group living, social animals prefer associate with individuals that provide most benefits, such as kin, familiar individuals, or those similar phenotypes. Such strategies are not necessarily stable over time but vary changing selection pressures. In particular, young transitioning independence should continuously adjust their behavior in light developmental changes....
Advances in biologging technologies have significantly improved our ability to track individual animals' behaviour their natural environment. Beyond observations, automation of data collection has revolutionized cognitive experiments the wild. For example, radio-frequency identification (RFID) antennae embedded 'puzzle box' devices allowed for large-scale where individuals tagged with passive integrated transponder (PIT) tags interact puzzle boxes gain a food reward, logging both identity...
Abstract As an important determinant of reproductive success, avian nest building is under strong selection and requires behavioral plasticity to optimize conditions in which offspring develop. Learning a one form that allows adaptation the local environment. Birds may refine nest-building behavior with personal experience or use social information guide their choices. While there mounting evidence for effect experience-based learning on when selecting nesting material laboratory,...
Abstract Social structuring from assortative associations may affect individual fitness, as well population-level processes. Gaining a broader understanding of social structure can improve our knowledge evolution and inform wildlife conservation. We investigated association patterns community female Indo-Pacific bottlenose dolphins ( Tursiops aduncus ) in Shark Bay, Western Australia, assessing the role kinship, shared culturally transmitted foraging techniques, habitat similarity based on...
Abstract Dietary flexibility allows animals to respond adaptively food pulses in the environment. Here we document novel emergence of widespread hunting California voles and carnivorous feeding behavior by ground squirrels. Over two months twelfth year a long-term study on squirrel population, 74 events juvenile adult squirrels both sexes depredating, consuming, and/or competing over vole prey. Our video footage, photographic evidence, direct observations marked individual provide insights...
Network-based diffusion analysis (NBDA) has become a widely used tool to detect and quantify social learning in animal populations. NBDA infers if the spread of novel behavior follows network hence relies on appropriate information individuals' connections. Most studies populations, however, lack complete record all associations, which creates uncertainty network. To reduce this uncertainty, researchers often use certain threshold sightings for inclusion animals (which is arbitrarily...
Objectives: Therapeutic approaches employing viral delivery of candidate genes are frequently associated with safety concerns. In contrast, non-viral methods mostly show only a rather low efficiency gene transfer. Therefore, we evaluated the usefulness modified mRNA (mod RNA) to efficiently deliver target into cells in vitro and whole organs vivo thereby also circumventing issue.