African Americans have the highest prevalence of hypertension in world which may emanate from their predisposition to heightened endothelial inflammation. The purpose this study was determine effects a 6-month aerobic exercise training (AEXT) intervention on inflammatory biomarkers interleukin-10 (IL-10), interleukin-6 (IL-6), and microparticle (EMP) CD62E+ function assessed by flow-mediated dilation (FMD) Americans. A secondary evaluate whether changes IL-10, IL-6, or EMPs predicted change...

As healthcare progresses toward individualized medicine, understanding how different racial groups respond to lifestyle interventions is valuable. It established that A frican mericans have disproportionate levels of cardiovascular disease and impaired vascular health, clinical practice guidelines suggest as the first line treatment. Recently, authors reported 6 months aerobic exercise improved inflammatory markers, flow‐mediated dilation ( FMD ), circulating endothelial microparticles EMP...

Objective African-American women represent an understudied population in menopause research yet face greater postmenopausal challenges associated with mortality than their white peers. We investigated the effects of a mild-intensity aerobic exercise training program on markers risk both premenopausal and women. Methods Sixteen 19 underwent 6 months training. Measurements included blood lipid glucose profile, inflammation, kidney function, vascular health, fitness before after intervention....

The effects of exercise training on nocturnal blood pressure (BP) dipping status remain unclear. African Americans have the highest prevalence nondippers compared with other racial/ethnic populations. In this 6-month study we tested hypothesis that long-term aerobic would increase levels BP in American nondippers.We recruited who were nondiabetic, nonsmoking, and free from cardiovascular renal disease. For analysis, only a nondipping profile, defined as those absence decline systolic or...

Background. C-reactive protein (CRP) is an independent biomarker of systemic inflammation and a predictor future cardiovascular disease (CVD). More than just pure bystander, CRP directly interacts with endothelial cells to decrease nitric oxide synthase (eNOS) expression bioactivity, (NO) production, increase the release vasoconstrictors adhesion molecules. Race significantly associated levels CVD risks. With aerobic exercise, vessel wall exposed chronic high laminar shear stress (HiLSS)...

Improvements in indices of vascular health and endothelial function have been inversely associated with hypertension, a risk factor for cardiovascular disease (e.g., myocardial infarction, stroke, heart failure), renal failure, mortality. Aerobic exercise training (AEXT) has positively improvements clinical values, as well biomarkers, function. The purpose this study was to evaluate whether measures adherence were related outcome subsequent 6-month AEXT intervention middle-to-older aged...

<p><strong>Purpose: </strong>Systemic inflammation, measured by C-reactive protein (CRP), is an important risk factor for cardiovascular disease (CVD) and mortality. We investigated whether aerobic exercise training (AEXT) affects African Americans with high inflammation (HI) the same way it does low (LI) in terms of CVD factors. </p><p><strong>Methods: </strong>23 CRP levels <3 mg/L 14 ≥3 underwent six months AEXT. Participants were...

Abstract Endothelial dysfunction is associated with the racial health disparity in vascular African Americans (AAs). Matrix Metalloproteinase (MMP)-2 constitutively expressed endothelial cells (EC) and a biomarker that has been hypertension, as its properties are involved pathologic oxidative stress pro-inflammation may affect homeostasis. Herein , we report significant inverse relationships between MMP-2, stroke volume, carotid aortic systolic pressures small cohort of young AA men. In...

Purpose: Evidence has accumulated to show that BP variability (BPV) a striking relationship with cardiovascular (CV) risk and is predictive of future CV events, independent mean BP. Despite the mounting evidence, scant attention been paid ability treatment modalities attenuate BPV. To best our knowledge, no previous study investigated efficacy non-pharmacologic on Therefore, purpose was investigate effects aerobic exercise training (AEXT) short- long-term BPV in non-hypertensive hypertensive...

Background C‐reactive protein (CRP) is an independent biomarker of inflammation and cardiovascular disease (CVD). CRP interacts directly with endothelial cells. decreases nitric oxide synthase (eNOS) expression bioactivity (NO) production. Race/ethnicity significantly associated CVD risks. Thus, the purpose this study was to assess racial differences concerning CRP‐induced biological effects in Methods Human umbilical vein cells (HUVECs) from four African American (AA) donors Caucasian (CA)...

Background: When compared to other racial groups, African American women (AAW) reach menopause at an earlier age and are increase risk for CVD endothelial health complications. A known intervention the treatment of both menopausal changes is aerobic exercise training (AEXT). The purpose this study was compare effects AEXT on function between pre- post- AAW. Methods: Sedentary, non-smoking AAW not hormone replacement therapy free completed AEXT. Participants exercised 65% their VO2max 40 min,...

Higher levels of plasma Endothelin-1 (ET1), a potent vasoconstrictor, have been reported in African Americans (AA) when compared to Caucasians (CA). However, this racial difference has never considered investigating the endothelin system at cell level. PURPOSE: To determine effects laminar shear stress (LSS), which mimics exercise on endothelium, vitro and aerobic training vivo. METHODS: AA (n=2) CA human umbilical vein endothelial cells (HUVECs) were cultured underwent LSS using cone plate...

African Americans (AA) have the highest prevalence of hypertension (HTN) in world which may emanate from their predisposition to heightened endothelial inflammation. Long-term exposure endothelium proinflammatory cytokines leads increased oxidative stress, inflammation, and dysfunction support an environment favoring HTN. It is thought that balance between pro- anti-inflammation plays a crucial role as determinant homeostasis health. Positive associations markers such C-reactive protein...

Background: Vascular cell adhesion molecule-1 (VCAM-1) mediates the of monocytes to vascular endothelium, which play a role in development endothelial dysfunction and atherosclerosis. Flow-mediation dilation (FMD) is an endothelium-dependent response, mediated by nitric oxide closely related function. The purpose study was test whether levels VCAM-1 were associated endothelial-dependent normotensive African Americans. Normotensives studied order eliminate influence hypertension. Methods...

Background Interleukin‐6 (IL‐6) is a pro‐inflammatory cytokine that can be excreted by endothelial cells. Elevated C‐reactive protein (CRP) level risk factor for the development of dysfunction lead to hypertension. The study was determine whether race or gender affected IL‐6 response CRP in HUVECs. Methods Eight HUVEC lines from African American (AA) and Caucasian (CA) donors with split evenly were cultured incubated 24‐hrs. Doses 0, 25, 50 100 μg/mL. measured media collected after...

Background: African Americans tend to have greater carotid intima-media thickness (IMT), and are 60% more likely a stroke than Caucasians. Data on the effects of lifestyle intervention IMT in does not exist. The aim our study was assess efficacy 6 months diet exercise sedentary American adults. Methods: Nineteen subjects (15F/4M, 52 ± 6yrs) who were sedentary, non smoking, diabetic, free cardiovascular disease, antihypertensive or cholesterol medications underwent weeks dietary counseling...

One of the precursors to hypertension (HTN) is systemic inflammation which can lead vascular dysfunction and eventually HTN. Aerobic exercise training (AEXT) known be an important intervention tool in prevention treatment HTN, dysfunction. However, no study has yet determined effect AEXT on normotensive versus non-normotensive participants. Purpose: To assess whether there are differential changes inflammatory marker C-reactive protein (CRP) participants response AEXT. METHODS: 27 ages 41-71...

Neurodegenerative diseases such as Alzheimer’s have recently been linked to hypertension (HTN). S100B is a marker of cerebral injury and the progression neuro-degeneration. Serum levels are known be increased after acute brain trauma, with chronic neuro-degenerative diseases, even in presence HTN. Optimization aerobic fitness has long implicated treatment prevention However, no study investigated whether exercise training (AEXT) an effect on associated neurodegenerative disease markers...

Background: African-Americans have increased morbidity and mortality rates from cardiovascular disease (CVD). Diminished flow mediated dilation (FMD) is associated with CVD. Our study aimed to assess the efficacy of 6-months diet exercise intervention on FMD in African-American subjects. Methods: subjects (N = 20, 17F/3 M, 53 ± 6yrs) who were sedentary, non-diabetic, non-smoking, free CVD not medication completed supervised aerobic training (3 days/week, 65% VO2max, 40 min/session). 6-weeks...

Background: Chronic inflammation and elevated levels of C reactive protein (CRP) can lead to reduced bioavailability endothelium relaxing factors such as Nitric Oxide (NO) increased production vasoconstrictive pro-inflammatory agents endothelin-1 (ET1). African Americans (AA) have impaired vasodilatory capabilities evident through NO bioavailability. The purpose this study was investigate the potential differential racial effect CRP on ET1 NO. METHODS: AA Caucasian (C) Human Umbilical Vein...