A5103200951- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 detection and testing
- Molecular Biology Techniques and Applications
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
- COVID-19 diagnosis using AI
- Viral Infections and Immunology Research
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- Bacteriophages and microbial interactions
- Viral-associated cancers and disorders
- Vaccine Coverage and Hesitancy
- Antimicrobial Resistance in Staphylococcus
- Fecal contamination and water quality
- Salmonella and Campylobacter epidemiology
Zealand University Hospital
2021-2024
Slagelse Hospital
2016-2024
Statens Serum Institut
2008-2021
Region Zealand
2020
Ringsted Sygehus
2014
Foundation Center
1998
Metagenomic high-throughput sequencing (mHTS) is a hypothesis-free, universal pathogen detection technique for determination of the DNA/RNA sequences in variety sample types and infectious syndromes. mHTS still its early stages translating into clinical application. To support development, implementation standardization procedures virus diagnostics, European Society Clinical Virology (ESCV) Network on Next-Generation Sequencing (ENNGS) has been established. The aim ENNGS to bring together...
Rapid and accurate detection of viral respiratory infections is important for infection control measures. This study compares the analytical clinical performance Xpert® Xpress CoV-2/Flu/RSV plus test ("Xpert", Cepheid) STANDARD™ M10 Flu/RSV/SARS-CoV-2 ("M10", SD Biosensor). Both tests are quadruplex RT-PCR assays rapid diagnosis SARS-CoV-2, influenza A/B RSV.
Background: Using nation-wide Danish register data, we investigated whether BA.2.86, including JN.1, differed from other circulating variants in terms of ability to escape vaccine protection, risk severe disease, and self-reported symptoms.Methods: We included all residents over 65 years age with a positive SARS-CoV-2 PCR test available genomic variant data between October 1, 2023 December 10, 2023. Data clinical testing, sentinel self-sampling-based surveillance were linked national...
The aim of this study was to investigate the value syndromic diagnostic testing for a better understanding epidemiology gastrointestinal infections in Denmark. Here we evaluated QIAstat-Dx® Gastrointestinal (GI) Panel 1 assay on 18,610 fecal samples requested analysis enteric pathogens Region Zealand, Denmark, year (October 1, 2021, September 30, 2022). In total, 6905 (37%) were detected positive one or more diarrhoeal bacteria, viruses, and protozoa. most common bacterial, viral, parasitic...
Implementing multiplex PCR or syndromic panel-based testing platforms to detect microbial species that cause acute diarrhoea may guide patient management more effectively and efficiently.To assess compare the performance of two systems, QIAstat-Dx® Gastrointestinal Panel V2 (QGI) Novodiag® Bacterial GE+ V2-0 (NGE).The QGI NGE panels include 16 14 bacterial gastrointestinal pathogens, respectively. The was tested retrospectively using 141 positive clinical stool specimens, External Quality...
Screening and pre-emptive isolation of at-risk patients are important aspects the Danish approach to prevention meticillin-resistant Staphylococcusaureus (MRSA) infection, but screening with conventional culture can take up 3 days for results become available attendant costs disadvantages prolonged isolation. We sought evaluate accuracy, time availability potential economic benefits two next-generation MRSA assays, Xpert Gen (GX MRSA) BD MAX XT, in a setting consolidated laboratory serving...
Abstract The use of highly active antiretroviral treatment (HAART) regimens with unboosted protease inhibitors (PIs) has resulted in a high level virological failure primarily due to the development resistant virus. Current boosted PI combine successfully low‐dose ritonavir (r) second PI. aim study was estimate proportion patients, population based setting, who develop on PI/r regimen. Through Danish HIV Cohort Study 1,007 patients received between 1995 and 2008 were identified. Twenty‐three...
HIV-1 from a patient with multi-drug resistant virus was identified as wild type during treatment interruption. The aim of the study to describe how viral population is affected by interruptions and use phylogeny reconstruct evolutionary pattern. 15 samples covering 13 y 2 were analysed in both pol env. found sample second interruption 2002 had not been present dominant since 1994. Phylogeny showed that more closely related sequences than other sampled 2002. This indicated caused recruitment...
Abstract A case of human infection with influenza A(H1N1)pdm09 virus containing a nonstructural gene highly similar to Eurasian avian-like H1Nx swine was detected in Denmark January 2021. We describe the clinical and report testing results genetic antigenic characterizations virus.
Background: Rapid and accurate detection of viral respiratory infections is important for infection control measures. This study compares the analytical clinical performance Xpert® Xpress CoV-2/Flu/RSV plus test (“Xpert”, Cepheid) STANDARD™ M10 Flu/RSV/SARS-CoV-2 (“M10”, SD Biosensor). Both tests are quadruplex RT-PCR assays rapid diagnosis SARS-CoV-2, influenza A/B RSV. Study designAnalytical sensitivities were determined by limit A, B RSV, respectively. Additionally, Xpert was evaluated...
BACKGROUND: Proposed testing of large plasma pools with genome amplification technology (GAT) for detection transfusion‐ transmissible viruses may have unanticipated complications not associated individual unit testing. One such potential complication, the effect dilution resulting from pool formation, was subject present study. STUDY DESIGN AND METHODS: Specimens three donor HIV type 1 (HIV‐1) seroconversion panels were tested a quantitative HIV‐1 RNA GAT assay (lower limit, 400 copies)....