A5044774584- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Bone fractures and treatments
- biodegradable polymer synthesis and properties
- Mesenchymal stem cell research
- Dental Implant Techniques and Outcomes
- Nerve Injury and Rehabilitation
- Surgical Sutures and Adhesives
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Connective tissue disorders research
- Artificial Intelligence in Healthcare and Education
- Biomedical and Engineering Education
- Shoulder Injury and Treatment
University of Southampton
2020-2025
Abstract Fracture non‐union occurs due to various factors, leading the development of potentially substantial bone defects. While autograft and allograft are current gold standards for fractures, challenges related availability immune rejection highlight need improved treatments. A strategy in tissue engineering is harness growth factors induce an effect on cells change their phenotype, behavior initiate signaling pathways which lead increased matrix deposition formation. Bone morphogenetic...
Biomaterial-based approaches for bone regeneration seek to explore alternative strategies repair non-healing fractures and critical-sized defects. Fracture non-union occurs due a number of factors resulting in the formation Rigorous evaluation biomaterials relevant models assessment their potential translate towards clinical use is vital. Large animal experimentation can be used model fracture while scaling-up materials use. Growth modulate cell phenotype, behaviour initiate signalling...
Abstract Fracture non-union occurs as a consequence of various factors, leading to the development potentially substantial bone defects. Biomaterial-based approaches for regeneration aim explore alternative strategies repair non-healing fractures and critical-sized Thus, rigorous assessment ability translate biomaterials towards clinical use is vital. Growth factors induce an effect on cells change their phenotype, behaviour initiate signalling pathways, matrix deposition tissue formation....
Abstract Bone tissue engineering aims to harness materials develop functional bone heal ‘critical-sized’ defects. This study examined a robust, coated poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold designed augment formation. Following optimisation of the coatings, three bioactive coatings were examined, i) elastin-like polypeptide (ELP), ii) poly(ethyl acrylate) (PEA), fibronectin (FN) and morphogenetic protein-2 (BMP-2) applied sequentially (PEA/FN/BMP-2) iii) both ELP...
Abstract Bone tissue engineering is a rapidly advancing field that seeks to develop new functional bone tissue, harnessing materials for application in defects which may fail heal without intervention, as seen critical-sized defects. The material properties must be developed, tailored and optimised the environment progresses, through increasing animal size complexity, of target defect site. This study has examined potential poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold...
Abstract Bone tissue engineering is a rapidly advancing field that seeks to develop efficacious approaches for treating non-healing fractures and large bone defects. Healing complications arise due trauma, disease, infection, aseptic loosening of orthopaedic implants or iatrogenic causes. An ideal biodegradable scaffold would induce support formation until the matrix sufficiently stable facilitate healing. The current study has examined augmentation, using functionalised coated scaffolds,...
Summary This paper reports the successful use of a half limb cast to treat prior failures in healing synovial hernia T horoughbred yearling. The was due nonhealing arthroscopy portal and confirmed using ultrasonography positive contrast arthrography visualise communication between metacarpophalangeal joint subcutaneous space. Surgery performed 3 times, failure capsule recurrence clinical signs. A applied following final surgery effected repair. At 2 months post there no swelling at repeat...
Abstract Biomaterial-based approaches for bone regeneration seek to explore alternative strategies repair non-healing fractures and critical-sized defects. Fracture non-union occurs due a number of factors resulting in the formation Rigorous evaluation biomaterials relevant models assessment their potential translate towards clinical use is vital. Large animal experimentation can be used model fracture while scaling-up materials use. Growth modulate cell phenotype, behaviour initiate...
Abstract Bone tissue engineering seeks to develop treatment approaches for nonhealing and large bone defects. An ideal biodegradable scaffold will induce support formation. The current study examines augmentation in critical‐sized defects, using functionalized scaffolds, with the hypothesized potential skeletal cell differentiation. 3D printed, porous poly(caprolactone) trimethacrylate (PCL‐TMA900) scaffolds are applied within a murine femur defect, stabilized by polyimide intramedullary...