A5101594747- FOXO transcription factor regulation
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and biological activity of medicinal plants
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Circular RNAs in diseases
- Metabolomics and Mass Spectrometry Studies
- Bioactive Natural Diterpenoids Research
- Cancer Treatment and Pharmacology
- Glycosylation and Glycoproteins Research
- Genetics and Neurodevelopmental Disorders
- Glioma Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biological and pharmacological studies of plants
- Cancer Mechanisms and Therapy
- Electromagnetic wave absorption materials
- Metabolism, Diabetes, and Cancer
Wuxi Fourth People's Hospital
2022-2025
Hubei University of Technology
2025
Shandong University
2025
Tianjin Medical University Cancer Institute and Hospital
2025
Jiangnan University
2023-2024
Xiamen University
2016-2021
Xiangya Hospital Central South University
2016-2017
Central South University
2014-2017
Toxicologie, Pharmacologie et Signalisation Cellulaire
2017
Abstract Paclitaxel is clinically used as a first-line chemotherapeutic regimen for several cancer types, including head and neck cancers. However, acquired drug resistance results in the failure of therapy, metastasis relapse. The efflux mediated by ATP-binding cassette (ABC) transporters survival signals activated forkhead box (FOX) molecules are critical development paclitaxel resistance. Whether FOX promote through remains unknown. In this study, we developed types paclitaxel-resistant...
FoxO transcription factors have been reported to play pivotal roles in tumorigenesis and drug resistance. The mechanisms underlying the tumor suppression function of FoxOs human cancers remain largely unknown. Aberrant expression activation Nrf2 often correlate with chemoresistance poor prognosis. Here, we report that FoxO3 directs basal Kelch‐like ECH‐associated protein 1 (Keap1), an adaptor bridges Cul3 for degradation. depletion resulted Keap1 down‐regulation, thereby activating...
Abstract The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 expression inversely correlates with node metastasis in human cancers. It remains unclear if is functionally distinct from cytosolic driving tumorigenesis and, any, how tumor cells sense insults to coordinate functions within these intracellular compartments. Here, we report an acetylation-dependent regulation of localization...
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis poorly understood. Lysine-specific demethylase 1 (LSD1) known to execute epigenetic regulation by forming corepressor complex with CoREST/histone deacetylases (HDACs). However, the molecular mechanisms which cells maintain LSD1/CoREST integrity are unknown. Here, it reported that LSD1 protein undergoes K63-linked polyubiquitination. responsible for deubiquitination at K226/277 residues,...
Geminin expression is essential for embryonic development and the maintenance of chromosomal integrity. In spite this protective role, geminin also frequently overexpressed in human cancers molecular mechanisms underlying its role tumor progression remain unclear. The histone deacetylase HDAC3 modulates transcription factors to activate or suppress transcription. Little known about how specifies substrates modulation among highly homologous factor family members. Here, we have demonstrated...
Androgen/AR is the primary contributor to prostate cancer (PCa) progression by regulating Prostate Specific Antigen (PSA) gene transcription. The disease inevitably evolves androgen-independent (AI) status. Other mechanisms which PSA regulated and develops AI have not yet been fully determined. FOXM1 a cell proliferation-specific transcription factor highly expressed in PCa cells compared non-malignant epithelial cells, suggesting that aberrant overexpression of contributes development. In...
Less-aggressive lower-grade gliomas (LGGs) frequently transform into glioblastoma (GBM). Most previous studies of have not focused on LGG-original high-risk subpopulations, which may be one the most critical hallmarks glioma progression. In this study, LGG samples are collected to perform single-cell sequencing (scRNA-seq) and identify a unique cell subpopulation marked by CDC20, KIF20A PTTG1, correlating with poor survival in multiple cohorts. Importantly, CDC20+KIF20A+PTTG1+ is strongly...
The Fc fragment of IgG binding protein (FCGBP) exhibits differential expression across various tumor types. but its role in cancer progression remains underexplored. This research discovered that FCGBP is downregulated colorectal (CRC) cells and negatively associated with poor prognosis. Overexpression inhibited the growth P53 wild-type CRC both vitro vivo. Mechanistically, immunoprecipitation experiments revealed competitively binds to MDM2, thereby attenuating formation P53/MDM2 complex....
Abstract The construction of 3D networks enhanced filler utilization in conductive composites, but heat‐induced liquefaction solid epoxy resins hindered internal structure formation. This study prepared semi‐cured particles (S‐E12‐RGs) by mixing and pre‐curing E12 with a curing agent. S‐E12‐RGs were combined liquid E51, additives, ethylenediamine‐modified nickel‐coated graphite (ENCG), then hot‐pressed into composites. crosslinking prevented ENCG's inward migration, which promoted its...
Gastric cancer patients harboring a TP53 mutation exhibit more aggressive and chemoresistant phenotype. Unfortunately, efforts to identify the vulnerabilities overcome these malignancies have made minimal progress in recent years. Therefore, there is an urgent need explore novel therapeutic strategies for this subclass. Histone methylation modulators are critical epigenetic targets therapies that help maintain of cancers mutations senescence evasion. Triggering now considered benefit...
BACKGROUND An increasing number of studies have focused on the role cellular metabolism in development colorectal cancer (CRC). However, no work is currently available to synthesize field through bibliometrics. AIM To analyze “glucose metabolism” (GM), “amino acid (AM), “lipid (LM), and “nucleotide (NM) CRC by visualization. METHODS Articles within abovementioned areas GM, AM, LM NM CRC, which were published from January 1, 1991, December 31, 2022, are retrieved Web Science Core Collection...
G protein-coupled estrogen receptor 1 (GPER-1) has gained recognition for its role in conferring cardioprotection. However, the extent to which GPER-1 exerts equally important effects both sexes remains unclear. The study found similar expressions of rat heart apex sexes. In male rats, administering epinephrine (Epi) at a dose 31.36 μg/100 g resulted rapid decline cardiac function, accompanied by sharp increase bax/bcl-2 levels. contrast, female rats did not display significant changes...