A5102027708- Block Copolymer Self-Assembly
- Acute Ischemic Stroke Management
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Anesthesia and Sedative Agents
- Pickering emulsions and particle stabilization
- Immune Cell Function and Interaction
- Advanced Materials and Mechanics
- Surfactants and Colloidal Systems
- Cancer Immunotherapy and Biomarkers
- Liquid Crystal Research Advancements
- Nausea and vomiting management
- Urinary Tract Infections Management
- Nanoparticle-Based Drug Delivery
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Systemic Lupus Erythematosus Research
- Pain Management and Opioid Use
- Thermal Regulation in Medicine
- Colorectal and Anal Carcinomas
- Material Dynamics and Properties
- Organic Electronics and Photovoltaics
- Urinary Bladder and Prostate Research
Ewha Womans University
2021-2025
Seoul National University Bundang Hospital
2024
Samsung Medical Center
2010-2024
Sungkyunkwan University
2010-2022
Samsung (South Korea)
2019-2022
Background Targeting the DNA damage repair (DDR) pathways is an attractive strategy for boosting cancer immunotherapy. Ceralasertib (AZD6738) oral kinase inhibitor of ataxia telangiectasia and Rad3 related protein, which a master regulator DDR. We conducted phase II trial ceralasertib plus durvalumab in patients with previously treated advanced gastric (AGC) to demonstrate safety, tolerability, clinical activity combination. Methods This II, open-label, single-center, non-randomized study...
ConspectusConjugated polymers have been actively studied as an alternative to inorganic semiconductors for their unique optical and electrical properties low-cost solution processability. However, typical conjugated polymer films contain numerous defects that negatively affect transport properties, which remains a major issue despite much effort develop ways improve the molecular packing structure. In principle, block copolymers (BCPs) composed of rod-type coil-type insulating can assemble...
Abstract Background Homologous recombination deficiency (HRD) stands as a clinical indicator for discerning responsive outcomes to platinum-based chemotherapy and poly ADP-ribose polymerase (PARP) inhibitors. One of the conventional approaches HRD prognostication has generally centered on identifying deleterious mutations within BRCA1/2 genes, along with quantifying genomic scars, such Genomic Instability Score (GIS) estimation scarHRD. However, scarHRD method limitations in scenarios...
Purpose: Total knee replacement is one of the most painful orthopedic procedures, and effective pain relief essential for early mobility discharge from hospital.The aim this study was to evaluate whether addition single-injection femoral nerve block epidural analgesia would provide better postoperative control, compared alone, after total replacement.Materials Methods: Thirty-eight patients received a with 0.25% levobupivacaine (30 mL) combined (femoral group) 40 alone (control group).Pain...
Background and purpose: Cardiac evaluation is routinely conducted in patients with ischaemic stroke because embolisms originating from the heart are an important cause of stroke. We compared prevalence cardioaortic sources cerebral embolism (CSCE) detected by transthoracic echocardiography (TTE) and/or multidetector cardiac computed tomography (MDCT). Additionaly, we investigated frequency severity asymptomatic coronary artery disease (CAD) who underwent MDCT. Methods: prospectively...
Objectives The diagnostic validity of clinical airway assessment tests for predicting difficult laryngoscopy in patients requiring endotracheal intubation were evaluated using receiver operating characteristic (ROC) curve analysis and a grey zone approach. Methods In this prospective observational study, during pre-anaesthetic visit. Predictive (i.e. Modified Mallampati [MMT] classification; upper lip bite test [ULBT]; mouth opening; sternomental distance; thyromental distance [TMD]; neck...
Herein, we report the directional stimuli-responsive self-assembly of gold nanoparticles (AuNPs) coated with a thermoresponsive block copolymer (BCP), poly(ethylene glycol)-b-poly(N-isopropylacrylamide) (PEG-b-PNIPAM) and charged small molecules. AuNPs modified PEG-b-PNIPAM possessing AuNP/PNIPAM/PEG core/active/shell structure undergo temperature-induced into one-dimensional (1D) or two-dimensional (2D) structures in salt solutions, morphology varying ionic strength medium. Salt-free is...
Hunner-type interstitial cystitis (HIC) is a chronic inflammatory condition of the bladder. However, it remains unclear whether there causal relationship between presence Hunner lesions and seemingly normal-appearing areas in bladder (non-Hunner lesions). This study aimed to investigate fundamental aspects HIC by examining potential genetic differences non-Hunner elucidate their role as markers progression suppression disease.
Despite numerous previous studies, there is little data on the effects of anesthetics clinical outcome after off-pump coronary arterial bypass grafting (OPCAB). Therefore, we retrospectively compared anesthetic choice in-hospital major adverse events (MAEs) and one-year cardiovascular cerebral (MACCEs) in patients undergoing OPCAB. Electronic medical records were reviewed 192 who received propofol-remifenanil total intravenous anesthesia (TIVA) propensity score-matched 662 isoflurane...
Colloidal nanoparticles are synthesized in a complex reaction mixture that has an inhomogeneous chemical environment induced by local phase separation of the medium. Nanoparticle syntheses based on micelles, emulsions, flow different fluids, injection ionic precursors organic solvents, and mixing metal with aqueous reducing agents well established. However, formation mechanism phase-separated medium is not understood because complexity originating from presence boundaries as nonuniform...
The core polymer of DNA block copolymer assemblies significantly affects the molecular and biological interactions corona.
We analyzed the incidence and causes of oral anticoagulant (OAC) cessation subsequent stroke after OAC withdrawal in a cohort Korean patients with atrial fibrillation.The Atrial Fibrillation Evaluation Registry Ischemic Stroke (K-ATTENTION) is multicenter study, merging registries from 11 tertiary centers Korea. The number interruption episodes reasons were reviewed hospital records. was defined when patient experienced ischaemic within 31 days withdrawal. Clinical variables compared between...
A hypercoagulable state in antiphospholipid antibody syndrome (APS) may cause many obstetric complications during the pregnancy and postpartum. Therefore, a pregnant woman with APS should be treated aspirin alone or combined either unfractionated heparin low molecular weight [1]. With antithrombotic prophylaxis, thrombocytopenia can often occur APS, those conditions confusions when conducting regional anesthesia for cesarean section. A 30-year-old (height of 160.4 cm body 73.7 kg) was...
4045 Background: Alterations in DNA damage response (DDR) and repair are associated with genomic instability increased somatic tumor mutational burden, modulating using specific inhibitors is a promising strategy to boost the efficacy of cancer immunotherapy. Ceralasertib an oral inhibitor serine/threonine protein kinase Ataxia Telangiectasia Rad3 Related (ATR), which crucial cell’s replication stress. Methods: This phase 2 trial was designed evaluate safety ceralasertib combination...