A5067151989- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Esophagitis
- Nutrition and Health in Aging
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- Musculoskeletal Disorders and Rehabilitation
- Urticaria and Related Conditions
- COVID-19 Clinical Research Studies
- Colorectal Cancer Treatments and Studies
- Pharmacological Effects of Natural Compounds
- Hidradenitis Suppurativa and Treatments
- Body Composition Measurement Techniques
- Clinical Nutrition and Gastroenterology
- Long-Term Effects of COVID-19
- Pancreatitis Pathology and Treatment
- Bone Metabolism and Diseases
Kazan State Medical University
2022-2025
Dagestan State Medical Academy
2023-2025
Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
2016-2023
Kazan Federal University
2017
Shiraz University of Medical Sciences
2015
.
Several studies have highlighted the role of host-microbiome interactions in pathogenesis inflammatory bowel disease (IBD), resulting an increasing amount data mainly focusing on Western patients. Because prevalence IBD newly industrialized countries such as those Asia, Middle East, and South America, there is mounting interest elucidating gut microbiota these populations. We present a comprehensive analysis several IBD-related biomarkers profiles functions unique population patients with...
The aim of the study was to taxonomic and functional composition gut microbiota in ulcerative colitis (UC) Crohn's disease (CD) patients identify key markers dysbiosis IBD.Fecal samples obtained from 95 IBD (78 UC 17 CD) as well 96 healthy volunteers were used for whole-genome sequencing carried out on SOLiD 5500 W platform. Taxonomic profiling performed by aligning reeds, not maped hg19, MetaPhlAn2 reference database. Reeds mapped using HUNAnN2 algorithm ChocoPhlAn database assess...
Abstract Background Sarcopenia is a progressive pathological condition which can present in inflammatory bowel disease (IBD) together with changes body composition. Aim To provide ultrasound assessment of muscle mass and bioimpedance analysis composition patients IBD. Methods: Material Method The study included 102 IBD, 50 (49%) ulcerative colitis (UC), 52 (51%) Crohn's (CD), 10 persons formed the control group (CG). average age IBD was 39,5 [28,5; 50] year, CG – 37 [26; 38] years. There...
To assess the muscle mass of patients with inflammatory bowel disease (IBD) using ultrasound. 102 IBD hospitalized in gastroenterology department Republican Clinical Hospital (Kazan) were involved study. Among them, 49% ulcerative colitis, 51% Crohn's disease, 10 people made up control group (CG). The median age was 39.5 [28.5; 50] years, CG - 37 [26; 38] years. There 52 (51%) women and 5 (50%) group. Patients examined to body index (BMI), mid-upper arm circumference (MUAC, cm) mid-thigh...
Clinical: Diagnosis and outcome S73 surgery, tissue specimens were obtained from normal inflamed mucosa in CD patients only healthy areas controls.Formalin-fixed, paraffin-embedded sections underwent pre-treatment with 3 cycles of microwave then CAS block solution.The incubated the polyclonal anti-human RAGE antibody at 1:1000 dilution.RAGE immunoreactivity was analyzed by immunoistochemistry epitelium lamina propria.Results: expression significantly higher both than controls (p = 0.01).In...
Damage of peripheral joints and spine is a frequent manifestation spondyloarthritis associated with inflammatory bowel diseases (IBD). One the most typical manifestations axial (axSpA) back pain (IBP), which determined according to IBP criteria International society for study (The Assessment SpondyloArthritis international Society – ASAS) 2009. The diagnosis axSpA based on identification combination changes in sacroiliac (presence sacroiliitis MRI or radiography) characteristic clinical...
The article presents a clinical case of new coronavirus infection in patient with CD. onset the viral occurred during severe exacerbation CD, what led to induction infliximab therapy. difficulty managing patients COVID-19 and immunoinflammatory diseases is discussed.
Abstract Background The aim of study was to compare the incidence joint damage and entheses upper lower extremities in patients with inflammatory bowel diseases (IBD). Methods 95 IBD pts were prospectively enrolled into study: 55 ulcerative colitis 40 - Crohn's disease. average age 32 (26; 37) years. duration disease 48 (12; 96) months. Using ultrasound, each pt examined 14 joints 68 enthesis extremities. vascularization detected power Doppler mode. presence synovitis established by...
The purpose — to evaluate the relationship between quality of life parameters and damage joints entheses in patients with inflammatory bowel diseases (IBD). Materials methods. study included 95 IBD (ulcerative colitis (UC) Crohn’s disease (CD)). was assessed using SF-36 questionnaire. Each patient underwent clinical ultrasound examination upper lower extremities. A comparative analysis frequency joint enthesis UC CD carried out. We also number affected IBD. Results. general parameter...
Inflammatory bowel diseases (IBD) are characterized by the development of various systemic manifestations. One significant extraintestinal manifestations IBD is a decrease in mineral density (BMD) (demineralization) bone tissue and osteoporosis (OP). The pathogenesis decreased BMD multifactorial: activity immune inflammation gastrointestinal mucosa, medication intake, malnutrition (low calcium intake), muscle fat mass, vitamin D deficiency, as well other factors contribute to such patients....
Inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), are autoinflammatory for which basic therapy is not always effective, some patients may require the use of biological therapy. The purpose was to evaluate clinical characteristics with IBD who were on Material methods. We included 70 treated observed at Republican Clinical Hospital in Kazan. Patients UC 41 (58%), CD — 29 (42%). Mean age 37 [28; 42] years old, 43% female. Results. 23 (33%) remission,...
Background: Sarcopenia is a progressive pathological condition which can present in inflammatory bowel disease (IBD) together with changes body composition. Aim. To provide ultrasound assessment of muscle mass and bioimpedance analysis composition patients IBD. Methods: The study included 77 IBD, 34 (44%) ulcerative colitis (UC) 43 (56%) Crohn's (CD), 10 persons formed the control group (CG). average age IBD was 39 [28; 50] year, CG – 37 [26.5; 38.5] years. There were (50%) women 5 CG....
The purpose — to reveal the clinical and socio-demographic characteristics of patients with liver biliary tract diseases depending on nosology; determine gender differences patients. Material methods. 292 were examined. inpatient treatment in Gastroenterology Department Republic Clinical Hospital or observed outpatient department. Results. Among patients, 123 (42,1%) had steatosis, 11 (3,8%) cholelithiasis, 6 (2,1%) Gilbert’s syndrome, 152 (52,0%) autoimmune disease (AILD). prevalence...
Background: Axial spondyloarthritis (axSpA) is a common extraintestinal manifestation of inflammatory bowel diseases (IBD). It recommended to be diagnosed in patients with IBD by association clinical features, such as Inflammatory Back Pain (IBP), and imaging, MRI X-ray. In axSpA without IBD, Ankylosing Spondylitis Assessment Society (ASAS) criteria are used for defining IBP. Their diagnostic performance not clear. The goal the study was evaluate prevalence (IBP) explore prognostic value...
Background: Changes in the composition of intestinal microbiota are assumed to be associated with onset and development inflammatory bowel diseases (IBD). The aim our study was identify taxonomic features patients ulcerative colitis (UC). Methods: included 46 UC (25 men 21 women, mean age 41.7 years). disease duration ranged from 1 year 36 years. All received 5-ASA as basic therapy. Whole genome sequencing carried out on SOLiD 5500 W platform (Life Technologies, Foster City, CA, USA)....
The article presents a clinical case of an orphan disease – Wilson’s disease, genetically determined metabolic disorder the microelement copper with its excessive accumulation in tissues and predominant damage to liver brain, as well other organs. A distinctive feature is pronounced polymorphism manifestations, which causes difficulty early diagnosis. In absence timely copper-eliminating therapy, steadily progresses decompensation cirrhosis. this case, only radical treatment method...
1 Казанский государственный медицинский университет 2 Республиканская клиническая больница (Татарстан) Семейные случаи аутоиммунного гепатита и первичного билиарного холангита встречаются редко -по данным литературы, около 1%.В статье представлены семейные аутоиммунных заболеваний печени у сибсов
Normal intestinal microbiota carries out the metabolic, immune, detoxification, and vitamin synthesising functions; its anti-mutagenic anti-carcinogenic role associated with ability to synthesise short-chain fatty acids (SCFA): acetic, propionic butyric has been proven as well The purpose of this study was assess main functional groups microorganisms according their value, determine content butyrate butyrate-producing bacteria in stool samples IBD patients. included 77 patients ulcerative...
Gut microbiota is shown to be linked with response steroids in some diseases (bronchial asthma, etc). Sufficient changes of intestinal microbial composition inflammatory bowel disease (IBD) patients were by numerous investigators. The aim the study was evaluate possible link between taxonomic IBD steroid-dependence and steroid-resistance status. included 94 patients. Steroid-dependence observed 18 out 94; steroid resistance – 2 Total DNA extracted from stool samples followed whole genome...