A5101489924- Magnesium Alloys: Properties and Applications
- Aluminum Alloys Composites Properties
- Biochemical and Molecular Research
- Hydrogen Storage and Materials
- Adenosine and Purinergic Signaling
- Aluminum Alloy Microstructure Properties
- Microstructure and mechanical properties
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Microfluidic and Bio-sensing Technologies
- Corrosion Behavior and Inhibition
- Cytomegalovirus and herpesvirus research
- Parasitic infections in humans and animals
- ATP Synthase and ATPases Research
- Traumatic Ocular and Foreign Body Injuries
- Receptor Mechanisms and Signaling
- Catalysis for Biomass Conversion
- Bacterial Infections and Vaccines
- Nanoporous metals and alloys
- Cancer Mechanisms and Therapy
- Microfluidic and Capillary Electrophoresis Applications
- Ocular Disorders and Treatments
- Pickering emulsions and particle stabilization
- RNA Interference and Gene Delivery
- Barrier Structure and Function Studies
Ministry of Education of the People's Republic of China
2009-2024
Mongolian National University of Medical Sciences
2024
Donghua University
2021
Northeastern University
2015-2019
Tianjin Medical University
2010-2016
Tianjin Medical University Eye Hospital
2015-2016
Pennsylvania State University
2012-2016
China XD Group (China)
2016
Xi'an Jiaotong University
2016
Heilongjiang Provincial Hospital
2016
Significance We present a unique acoustic well approach that can precisely control cell-to-cell distance and cell–cell interactions. Our technology achieve high precision throughput simultaneously while preserving the integrity of cells. It is capable creating cell assemblies with precise spatial both in suspension on substrate. envision exploitation this powerful technology, for example, study interactions fields, such as immunology, developmental biology, neuroscience, cancer metastasis,...
Purine biosynthetic enzymes organize into dynamic cellular bodies called purinosomes. Little is known about the spatiotemporal control of these structures. Using super-resolution microscopy, we demonstrated that purinosomes colocalized with mitochondria, and results were supported by isolation purinosome mitochondria. Moreover, number purinosome-containing cells responded to dysregulation mitochondrial function metabolism. To explore role intracellular signaling, performed a kinome screen...
Therapeutic proteins have attracted significant attention as they perform vital roles in various biological processes. Polymeric nanoparticles can offer not only physical protection from environmental stimuli but also targeted delivery of such to specific sites, enhancing their therapeutic efficacy.
Significance We show that the assembly/disassembly of purinosome is cell cycle-dependent and correlates with cellular demands for purine biosynthesis encountered during cycle. The number purinosome-containing cells fluctuates: it peaks in G 1 phase HeLa cultured under purine-depleted conditions, but remains high across , S, 2 /M phases fibroblasts incapable salvage owing to a deficiency hypoxanthine-guanine phosphoribosyltransferase. Thus, function biomarker increased metabolic flux through...
Purine nucleotides are ubiquitous molecules that play vital roles in all kingdoms of life, not only as components nucleic acids, but also participating signaling and energy storage. Cellular pools purines maintained by the tight control several complementary sometimes competing processes including de novo biosynthesis, salvage catabolism nucleotides. While great strides have been made over past sixty years understanding biosynthesis purines, we experiencing a renaissance this field. In...
The de novo biosynthesis of purines is carried out by a highly conserved metabolic pathway that includes several validated targets for anticancer, immunosuppressant, and anti-inflammatory chemotherapeutics. six enzymes in humans catalyze the 10 chemical steps from phosphoribosylpyrophosphate to inosine monophosphate were recently shown associate into dynamic multiprotein complex called purinosome. Here, we demonstrate heat shock protein 90 (Hsp90), 70 (Hsp70), cochaperones functionally...
The enzymes in the human de novo purine synthesis pathway were found to form a cellular complex, purinosome, upon culturing cells purine-depleted medium (An, S., Kumar R., Sheets, E. D., and Benkovic, S. J. (2008) Science 320, 103-106). Purinosome formation dissociation be modulated by several factors, including microtubule network cell signaling involving protein phosphorylation. To determine whether are physical contact, we probed for protein-protein interactions (PPIs) within purinosome...
MINT‐7968768, MINT‐7968779: Tudor‐SN (uniprotkb:Q7KZF4) physically interacts (MI:0915) with G3BP (uniprotkb:Q13283) by anti bait coimmunoprecipitation (MI:0006) MINT‐7968800: and TIA‐1 (uniprotkb:P31483) colocalize (MI:0403) fluorescence microscopy (MI:0416) MINT‐7968789:
Five-fold symmetry was forbidden for the periodic crystals until discovery of Al-Mn icosahedral quasicrystal. We report a kind precipitated rod-shaped nanophase containing five-fold but not belonging to any or quasicrystals discovered so far. These metastable nanodomain phases, which in Mg-6Zn alloy during isothermal aging at 200 °C, contain two separate unit cells 2D plane perpendicular axis with atom arrangement along axis, that is, 72° rhombus structure and equilateral hexagon structure....
The γ″ nanosaucer precipitates in many Mg-RE-Zn(Ag) alloys, also named the G. P. zones some cases such as Mg–Ca–Al(Zn) play critical role strengthening α-Mg matrix and enhancing their creep resistance. However, previous reports on crystal structure of phase are still controversial at present, thus it is hard to correlate with mechanical properties Mg alloys. In this study, we confirmed a new topological close-packed (TCP) for precipitate typical peak-aged Mg–Gd–Zn alloy using Cs-corrected...
A novel intermetallic Mg 7 Ag 3 phase in the Mg–Ag binary alloy system at 573 and 623 K was discovered by diffusion couple technique combined with equilibrated method. The composition crystal structure of were identified via scanning electron microscopy/energy dispersive spectrometry, X-ray diffractometry (XRD), backscatter diffraction (EBSD) transmission microscopy (TEM). refinement XRD patterns performed Rietveld analysis. data have shown that crystallizes a body-centered Immm...
This paper reports a new structured prismatic platelet, self-assembled by an ellipse-like quasi-unit cell, precipitated in Mg–In–Yb and Mg–In–Ca ternary alloys aged isothermally at 200°C using aberration-corrected high-angle annular dark-field scanning transmission electron microscopy combined with density functional theory computations. The ordered stacking of solute atoms along the [0001] α direction based on elliptically shaped self-adapted clustering leads to generation cell. bonding...