A5090807299- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- Lysosomal Storage Disorders Research
- Studies on Chitinases and Chitosanases
- Animal Virus Infections Studies
- Calcium signaling and nucleotide metabolism
- COVID-19 Clinical Research Studies
- Plant Virus Research Studies
- Cellular transport and secretion
- Viral Infections and Outbreaks Research
- Lipid Membrane Structure and Behavior
- RNA regulation and disease
- Viral Infections and Immunology Research
- Vector-Borne Animal Diseases
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- interferon and immune responses
- Machine Learning in Bioinformatics
- Cholesterol and Lipid Metabolism
- Receptor Mechanisms and Signaling
- Vector-borne infectious diseases
International Centre for Genetic Engineering and Biotechnology
2020-2023
Leibniz Institute of Virology (LIV)
2023
German Cancer Research Center
2017
Heidelberg University
2017
Jaypee Institute of Information Technology
2012-2016
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus responsible for disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 was reported to alter several cellular pathways, its impact on DNA integrity and mechanisms involved remain unknown. Here we show that causes damage elicits an altered response. Mechanistically, proteins ORF6 NSP13 cause degradation of response kinase CHK1 through proteasome autophagy, respectively. loss leads deoxynucleoside triphosphate (dNTP)...
There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in current COVID-19 pandemic and contain future similar emergencies early on. Specific side-chain cholesterol oxidation products of oxysterols family have been shown inhibit a large variety both enveloped non-enveloped human viral pathogens. Here we report on vitro inhibitory activity redox active oxysterol 27-hydroxycholesterol one common cold agents HCoV-OC43 without significant cytotoxicity. Interestingly,...
Repurposing clinically available drugs to treat the new coronavirus disease 2019 (COVID-19) is an urgent need in course of Severe Acute Respiratory Syndrome (SARS-CoV-2) pandemic, as very few treatment options are available. The iminosugar Miglustat a well-characterized drug for rare genetic lysosome storage diseases, such Gaucher and Niemann-Pick type C, has also been described be active against variety enveloped viruses. activity here demonstrated micromolar range SARS-CoV-2 vitro. acts at...
Remodeling of the cellular endomembrane system by viruses allows for efficient and coordinated replication viral genome in distinct subcellular compartments termed organelles. As a critical step life cycle, organelle formation is an attractive target therapeutic intervention, but factors central to this process are only partially understood. In study, we corroborate that two proteins, nsp3 nsp4, major drivers membrane remodeling SARS-CoV-2 infection. We further report number host cell...
Orthoflavivirus infections represent an increasing public health burden, with several members of the genus emerging or re-emerging globally. Despite availability few vaccines, no antiviral drugs are currently licensed for treatment orthoflavivirus infections. Several pre-clinical studies identified non-structural protein 4B (NS4B), one least characterized viral proteins within genus, as most promising target development potent direct-acting antivirals. However, its functional roles in...
Formation of virus specific replicase complex is among the most important steps that determines fate viral transcription and replication during Chikungunya (CHIKV) infection. In present study, authors have computationally generated a 3D structure CHIKV late on basis interactions identified domains nonstructural proteins (nsPs) which make up complex. The nsPs were using systems such as pull down, protein interaction ELISA, yeast two-hybrid. structures I-TASSER biological assembly was...
Chandipura virus (CHPV), alike other pathogens, exploits the cellular infrastructure of their hosts through complex network interactions for successful infection. CHPV being a recently emerged pediatric encephalitic virus, mechanisms involved in establishment viral persistence are still ill defined. Because protein interface between and its host provides one means by which invades seize control human machinery, authors this study have employed computational methods to create putative...
Abstract Repurposing clinically available drugs to treat the new coronavirus disease COVID-19 is an urgent need in these early stages of SARS-CoV-2 pandemic, when very few treatment options are available. The iminosugar Miglustat a well-characterized drug for rare genetic lysosome storage diseases such as Gaucher and Niemann-Pick type C, has also been described be active against variety enveloped viruses. activity here demonstrated at concentrations achievable plasma by current clinical...
The nucleocapsid (N) protein of Chandipura virus (CHPV) plays a crucial role in viral life cycle, besides being an important structural component the virion through proper organization its interactions with other proteins. In recent study, authors had mapped associations among CHPV proteins and shown that N interacts four proteins: N, phosphoprotein (P), matrix (M), glycoprotein (G). present study aimed to distinguish regions responsible for this direction, we have generated structure by...
Chikungunya virus (CHIKV) non-structural protein 2 (nsP2) is considered to be the master regulator of viral RNA replication and host responses generated during infection. This has two main functional domains: an N-terminal domain which exhibits NTPase, triphosphatase helicase activities a C-terminal protease domain. Understanding how CHIKV nsP2 interacts with its proteins essential for elucidating all required processes pathogenesis along identification potential targets antiviral therapy....
The coding-complete genome sequence of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain isolated from an Iraqi patient was sequenced for the first-time using Illumina MiSeq technology. There D614G mutation in spike protein-coding sequence. This report is valuable better understanding spread virus Iraq.
Here, we report the genome sequences of five severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains that were obtained from symptomatic individuals with travel histories during community surveillance in Dominican Republic 2020. These provide a starting point for further genomic studies gene flow and molecular diversity Caribbean nation. Phylogenetic analysis suggests all genomes correspond to B.1 variant.