A5082825046- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Plant-Microbe Interactions and Immunity
- Fungal Biology and Applications
- ATP Synthase and ATPases Research
- Mycotoxins in Agriculture and Food
- Mitochondrial Function and Pathology
- NF-κB Signaling Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Plant tissue culture and regeneration
- Infant Nutrition and Health
- Ocular Infections and Treatments
- Metabolism and Genetic Disorders
- Advanced Drug Delivery Systems
- Carbohydrate Chemistry and Synthesis
Jilin University
2020-2025
Jilin Medical University
2020
Aspergillus fumigatus (A. fumigatus) is a filamentous fungus that causes invasive aspergillosis in immunocompromised individuals. Regulating fungal growth crucial for preventing disease development. This study found deleting the guanine nucleotide exchange factor Sec2p gene led to slower A. and reduced burden mortality of infected mice. However, mechanism by which this affects pathogenicity remains unclear. Transmission electron microscopy revealed vacuoles knockout strain ΔSec2p accumulated...
Staphylococcus aureus (S. aureus) is one of the most important zoonotic pathogens and can be transmitted to humans through meat diet routes, causing necrotising pneumonia. This study investigated therapeutic effect bacteriophage lysin LysGH15 on pneumonia in rabbit model caused by S. aureus. In vitro experiments, 50 μg/mL not only significantly reduced viable count (approximately 3.24 × 106 CFU/g) chicken stored at 4°C for 48 h but also effectively thawed 30°C, with reductions approximately...
Serine protease Omi/HtrA2, a member of the HtrA family, is closely related to maintenance mitochondrial integrity and participates in apoptosis but its role cerebral ischemia/reperfusion (I/R) injury cellular oxidative stress response remains unclear. In this study, we found that I/R resulted time-dependent increase Omi/HtrA2 expression rat brain tissue. Inhibition significantly inhibited XIAP cleavage H2O2-induced PC12 cells. addition, inhibition up-regulation proteins CHOP ClpP, reduced...
Abstract Purpose Sporothrix schenckii is a thermally dimorphic fungus. In saprotrophic environment or culturing at 25 °C, it grows as mycelia, whereas in host tissues 37 undergoes transition and division into pathogenic yeast cells. S. can cause serious disseminated sporotrichosis immunocompromised hosts presents an emerging global health problem. The mycelium-to-yeast was consequence of the adaptive process to different environment. Some studies showed that significantly related virulence...
Aspergillus fumigatus is an important opportunistic pathogenic fungus that causes invasive aspergillosis in immunocompromised humans. Regulated fungal growth essential for disease development and progression. Thus, screening genes regulate may lead to the identification of potential therapeutic targets (IA). Screening transfer DNA (T-DNA) random-insertion A. mutants identified a severe deficiency mutant AFM2954 featured sat1 as mutated gene described putative intracellular protein...
ABSTRACT Aspergillus fumigatus is an opportunistic pathogen that infects immunocompromised patients and imposes a heavy burden on global health. Searching for key genes in host resistance to A. infection can help us understand the mechanisms of -host interactions provide new targets treatment fungal infections. TRAF3 one intracellular adapter proteins innate immune response regulates signaling various cellular processes, including defense against pathogens. However, mechanism remains...
Abstract Background Fusarium species are important pathogenic organisms, which can cause many diseases in plants and humans. Characterizing the mechanism underlying their pathogenicity drug resistance is critical. Agrobacterium tumefaciens -mediated genetic transformation has been widely used for molecular analysis of species. Results In this study, we constructed pXEN recombinant plasmid carrying neomycin phosphatase II gene ( neo ) established a simple efficient procedure resistant...