A5090660291- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Dementia and Cognitive Impairment Research
- Cancer Risks and Factors
- Heart Failure Treatment and Management
- HIV Research and Treatment
- Lymphoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Uterine Myomas and Treatments
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Ovarian function and disorders
- Alzheimer's disease research and treatments
- Reproductive Health and Technologies
- Prostate Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- HIV/AIDS Research and Interventions
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
- Endometriosis Research and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cancer survivorship and care
- Electrolyte and hormonal disorders
- Reproductive System and Pregnancy
Mayo Clinic in Florida
2003-2025
Mayo Clinic
2004-2024
Colorado School of Public Health
2021-2024
Women’s Health Care
2024
Mayo Clinic in Arizona
2023-2024
Community Link
2024
WinnMed
2023-2024
Center for Global Health
2023
University of Colorado Anschutz Medical Campus
2019-2023
University of Colorado Denver
2019-2023
Cardiac arrhythmias are remarkably common and routinely go undiagnosed because they often transient asymptomatic. Effective diagnosis treatment can substantially reduce the morbidity mortality associated with cardiac arrhythmias. The Zio Patch (iRhythm Technologies, Inc, San Francisco, Calif) is a novel, single-lead electrocardiographic (ECG), lightweight, Food Drug Administration-cleared, continuously recording ambulatory adhesive patch monitor suitable for detecting in patients referred...
Pancreatic ductal adenocarcinoma (PDAC) remains resistant to chemotherapy and immunotherapy individually because of its desmoplastic stroma immunosuppressive tumor microenvironment. Synergizing cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) immune checkpoint blockade with could overcome these barriers. Here we present results a phase Ib trial combining ipilimumab gemcitabine in advanced PDAC.This was single-institution study 3 + dose-escalation design. The primary objective determine...
ABSTRACT Worldwide, HIV-1 infects millions of people annually, the majority whom are women. To establish infection in female reproductive tract (FRT), male ejaculate must overcome numerous innate and adaptive immune factors, traverse genital epithelium, underlying CD4 + target cells. How virus achieves this remains poorly defined. By utilizing a new technique, we define how interacts with different tissues FRT using human cervical explants vivo exposure rhesus macaque vaginal transmission...
<h3>Objective</h3> Ultrastaging is accurate in detecting nodal metastases, but increases costs and may not be necessary certain low-risk subgroups. In this study we examined the risk of involvement detected by sentinel lymph node (SLN) biopsy a large population apparent early-stage endometrial cancer stratified histopathologic characteristics. Furthermore, aimed to identify subgroup which ultrastaging omitted. <h3>Methods</h3> We retrospectively included patients who underwent SLN (with...
Myelofibrosis is characterized by bone marrow fibrosis, atypical megakaryocytes, splenomegaly, constitutional symptoms, thrombotic and hemorrhagic complications, a risk of evolution to acute leukemia. The JAK kinase inhibitor ruxolitinib provides therapeutic benefit, but the effects are limited. purpose this study was determine whether targeting AURKA, which has been shown increase maturation potential benefit for patients with myelofibrosis.Twenty-four myelofibrosis were enrolled in phase I...
The prognostic significance of isolated tumor cells (≤0.2 mm) in sentinel lymph nodes (SLNs) endometrial cancer patients is still unclear. Our aim was to assess the value with low risk who underwent SLN biopsy and did not receive adjuvant therapy. Outcomes were compared node negative patients. Patients SLNs-isolated between 2013 2019 identified from 15 centers worldwide, while Mayo Clinic, Rochester, 2018. Only (stage IA, endometrioid histology, grade 1 or 2) any therapy included. Primary...
A series of doxorubicin-loaded polymer-caged nanobins (PCNDXR) were evaluated in vivo a murine MDA-MB-231 xenograft model triple-negative breast cancer. The cross-linked polymer cage PCNDXR offers protection for the drug payload while serving as pH-responsive trigger that enhances release acidic environments commonly seen solid tumors and endosomes. Varying degree cross-linking allows surface potential PCNDXR, thus circulation lifetime nanocarriers, to be tuned facile fashion. Given these...
Arginine vasopressin (AVP) levels are elevated in proportion to heart failure severity and associated with higher cardiovascular mortality ambulatory patients. However, the relationship between baseline trends AVP outcomes patients hospitalized for worsening reduced ejection fraction is unclear.The Efficacy of Vasopressin Antagonism Heart Failure Outcome Study Tolvaptan (EVEREST) trial investigated effects tolvaptan ≤40%. The present analysis examined follow-up 3196 EVEREST valid...
To gain insight into female-to-male HIV sexual transmission and how male circumcision protects against this mode of transmission, we visualized HIV-1 interactions with foreskin penile tissues in ex vivo tissue culture rhesus macaque models utilizing epifluorescent microscopy. 12 14 cadaveric specimens were cultured R5-tropic photoactivatable (PA)-GFP for 4 or 24 hours. Tissue cryosections immunofluorescently imaged epithelial immune cell markers. Images analyzed total virions, proportion...
Low-Vt ventilation lowers mortality in patients with acute respiratory distress syndrome (ARDS) but is underused. Little known about clinician attitudes toward and perceived barriers to low-Vt use their association actual use.The objectives of this study were assess clinicians' (Vt <6.5 ml/kg predicted body weight) ARDS, identify differences among types, compare ARDS.We conducted a survey critical care physicians, nurses, therapists at four non-ARDS Network hospitals the Chicago region. We...
The neurofibrillary tangles (NFT) and amyloid-ß plaques (AP) that comprise Alzheimer's disease (AD) neuropathology are associated with neurodegeneration microglial activation. Activated microglia exist on a dynamic spectrum of morphologic subtypes include resting, surveillant capable converting to activated, hypertrophic closely linked neuroinflammatory processes AD in amnestic AD. However, quantitative analyses neurons lacking non-amnestic clinical variants, including primary progressive...
Primary progressive aphasia is a neurodegenerative disease that selectively impairs language without equivalent impairment of speech, memory or comportment. In 118 consecutive autopsies on patients with primary aphasia, diagnosis was Alzheimer's neuropathological changes (ADNC) in 42%, corticobasal degeneration supranuclear palsy neuropathology 24%, Pick's 10%, transactive response DNA binding proteinopathy type A [TDP(A)] TDP(C) 11% and infrequent entities 3%. Survival longest (13.2 ± 2.6...
To assess the distribution of molecular classes and their impact on risk recurrence in endometrial cancer patients with lymph node metastasis at time primary surgery. Endometrial micrometastasis or macrometastasis (International Federation Gynecology Obstetrics (FIGO) 2009 stage IIIC) after surgical staging five referral centers worldwide from October 2013 to September 2022 who underwent classification were identified. cancers categorized into four classes: POLE mutated, mismatch repair...
To introduce a novel approach for the time-dependent quantification of risk factors prostate cancer (PCa) detection after an initial negative biopsy.Data 1,871 men with biopsies and at least one follow-up biopsy were available. Piecewise exponential regression models developed to quantify hazard ratios (HRs) define cumulative incidence curves PCa subgroups specific patterns over time. Factors evaluated included age, race, serum prostate-specific antigen (PSA) concentration, PSA slope,...
Slow wave and spindle coupling supports memory consolidation, loss of is linked with cognitive decline neurodegeneration. Coupling proposed to be a possible biomarker neurological disease, yet little known about the different subtypes that normally occur throughout human development aging. Here we identify distinct spindles within slow upstates describe their relationships sleep stage across lifespan.Coupling cross-sectional cohort 582 subjects was quantified from stages N2 N3 ages 6-88...
Transvaginal ultrasound is typically the initial diagnostic approach in patients with postmenopausal bleeding for detecting endometrial atypical hyperplasia/cancer. Although transvaginal demonstrates notable sensitivity, its specificity remains limited. The objective of this study was to enhance accuracy through integration artificial intelligence. By using images, we aimed develop an intelligence based automated segmentation model and classifier model. Patients undergoing sampling at Mayo...