A5082577947- Metabolism, Diabetes, and Cancer
- Rheumatoid Arthritis Research and Therapies
- Neuroscience and Neuropharmacology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Protein Kinase Regulation and GTPase Signaling
- Pancreatic function and diabetes
- Ion channel regulation and function
- Autoimmune and Inflammatory Disorders Research
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Bone health and treatments
- Cellular transport and secretion
- Birth, Development, and Health
- Bone health and osteoporosis research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Lipid metabolism and biosynthesis
- Cell Adhesion Molecules Research
- Musculoskeletal synovial abnormalities and treatments
- Bone Metabolism and Diseases
- Nuclear Receptors and Signaling
- Cancer, Lipids, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
Kyushu University
2016-2025
Oxford Biotherapeutics (United Kingdom)
2016-2022
Japan Community Healthcare Organization
2014-2021
Kyushu Dental University
2019
Center for Rheumatology
2015
Nagasaki Municipal Hospital
2005-2014
Prefectural University of Hiroshima
2009
Citizen (Japan)
2005
Nagasaki University
1994-2000
The uncarboxylated form (ucOC), but not the γ-carboxylated (GlaOC), of bone-derived protein osteocalcin stimulates insulin secretion and regulates energy metabolism in target tissues. Glucagon-like peptide-1 (GLP-1) is an secretagogue that released from gut response to food intake. We have now found Gprc6a, a putative ucOC receptor, expressed epithelial cells mouse small intestine as well STC-1 enteroendocrine cells. Secretion GLP-1 by was stimulated GlaOC. serum concentration mice increased...
Abstract Background The incidence of Alzheimer's disease (AD)—the most frequent cause dementia—is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles regulatory factors such microRNAs (miRNAs) could contribute more accurate diagnosis treatment. Methods A systematic...
The subunit composition of GABA A receptors is known to be associated with distinct physiological and pharmacological properties. Previous studies that used phospholipase C-related inactive protein type 1 knock-out (PRIP-1 KO) mice revealed PRIP-1 involved in the assembly and/or trafficking γ2 subunit-containing receptors. There are two PRIP genes mammals; thus roles might compensated partly by those PRIP-2 KO mice. Here we double (PRIP-DKO) examined for regulating Consistent previous...
<h3>OBJECTIVE</h3> A high seroprevalence of HTLV-I in female Sjögren's syndrome (SS) patients has been reported Nagasaki, Japan, an area that is heavily endemic for infection. Salivary IgA class antibodies to were common among seropositive with SS. This study was undertaken elucidate the pathogenesis SS caused by <h3>METHODS</h3> The clinical features and histological findings prevalence serum autoantibodies 10 associated myelopathy (HAM) who consecutively admitted into Nagasaki University...
Abstract The uncarboxylated form of osteocalcin (GluOC) regulates glucose and lipid metabolism in mice. We previously showed that low-dose (≤10 ng/ml) GluOC induces the expression adiponectin peroxisome proliferator-activated receptor γ (PPARγ) via a cAMP–PKA–ERK–CREB signaling pathway 3T3-L1 adipocytes. also noticed high-dose (≥20 inhibits PPARγ these cells. have here explored mechanism underlying effects GluOC. High-dose triggered morphological changes adipocytes suggestive induction cell...
The purpose of this study was to develop a method for quantitative analysis the sonographic features parotid glands as noninvasive tool diagnosis Sjögren's syndrome.Sonographic texture analyses were performed on 44 patients with syndrome, 83 healthy volunteers, and 17 chronic parotitis, using fast Fourier transform program.Texture studies gland showed that sum normalized radial power spectrum in low-spatial-frequency region (S value) significantly higher (p < .0001) definite syndrome [6.70...
Abstract The thymus gland is crucial for the formation of thymocytes diverse TCR specificity. Recent studies have demonstrated that deletion (negative selection) autoreactive occurs through process apoptosis in which activates cell death by DNA fragmentation. In addition, vitro stimulation with anti-CD3 mAb, calcium ionophore, or glucocorticoids results fragmentation followed death. availability various substances capable inhibiting activation-induced programmed may be used as a tool to help...
Abstract A mechanism for regulating the strength of synaptic inhibition is enabled by altering number GABA receptors available at cell surface. Clathrin and adaptor protein 2 (AP2) complex‐mediated endocytosis known to play a fundamental role in surface receptor numbers. Very recently, we have elucidated that phospholipase C‐related catalytically inactive (PRIP) molecules are involved phosphorylation‐dependent regulation internalization through association with β subunits phosphatases. In...
Uncarboxylated osteocalcin (GluOC), a bone-derived hormone, regulates energy metabolism by stimulating insulin secretion, pancreatic β-cell proliferation, and adiponectin expression in adipocytes. Previously, we showed that long-term intermittent or daily oral administration of GluOC reduced the fasting blood glucose level, improved tolerance, increased serum concentration as well area female mice fed normal high-fat, high-sucrose diet. We have now performed similar experiments with male...
Obesity is characterized by macrophage infiltration into adipose tissue. White tissue remodelling under inflammatory conditions involves both hypertrophy and adipogenesis regulated transcription factors, which are influenced bone morphogenetic protein (BMP) signalling. MicroRNAs (miRNAs) regulate gene expression involved in obesity-related processes such as adipogenesis. Therefore, we identified differentially expressed miRNAs the epididymal white (eWAT) of mice fed a normal diet (ND) those...
Abstract Alzheimer's disease (AD) is less prevalent in men than women, although mechanisms remain unclear. Microglia degrade aggregated amyloid β (Aβ) through the lysosomal system, including autophagy. G protein‐coupled receptor family C group 6 member A (GPRC6A), predominantly expressed mouse microglial MG6 cells, a primary mediator of testosterone signaling. This study examines testosterone's role modulating Aβ‐induced autophagy microglia. Testosterone promotes leading to Aβ clearance...
Autoinflammatory diseases include a large spectrum of monogenic diseases, e.g. familial Mediterranean fever (FMF), as well complex genetic trait adult-onset Still's disease (AOSD). In populations where FMF is common, an increased MEFV mutation rate found in patients with rheumatic diseases. The aim this study was to examine mutations Japanese AOSD. Genomic DNA isolated from 49 AOSD and 105 healthy controls, exons 1, 2, 3 10 the gene genotyped by direct sequencing. frequencies were compared...
FK506 is an immunosuppressive drug that inhibits T cell receptor-mediated signal transduction. This can induce immunological tolerance in allograft recipients. In this study, we investigated the vivo effects of on apoptosis induction. Injection anti-CD3 antibody (Ab) mice resulted elimination CD4+ CD8+ thymocytes by DNA fragmentation. treatment significantly augmented thymic induced Ab administration. Increased disappearance after Ab/FK506 treatment. fragmentation triggered was exclusively...