A5084650124- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Poverty, Education, and Child Welfare
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Global Maternal and Child Health
- Migration, Health and Trauma
- Systemic Lupus Erythematosus Research
- Advanced biosensing and bioanalysis techniques
- Reproductive Health and Contraception
- IL-33, ST2, and ILC Pathways
- Male Reproductive Health Studies
- Early Childhood Education and Development
- Ureteral procedures and complications
- RNA Interference and Gene Delivery
- Food Security and Health in Diverse Populations
- Immune Response and Inflammation
George Washington University
2024-2025
Milken Institute
2024-2025
Pennsylvania State University
2021-2025
Hershey (United States)
2022
Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we show a B cell-intrinsic role for signal transducer activator transcription 3 (STAT3) in GC DZ LZ organization. Altered zonal organization STAT3-deficient GCs dampens development long-lived plasma cells (LL-PCs) but increases memory (MBCs). In an abundant antigenic environment, achieved here by prime-boost immunization, STAT3 is not required initiation, maintenance, or...
Young adults' access to contraception is shifting after the June 2022 United States Supreme Court Dobbs v. Jackson Women's Health Organization decision. This concurrent mixed-methods study measured young use of and perceptions about tubal sterilization vasectomy leaked opinion in May 2022. Using national-level medical claims data from IQVIA, we conducted difference-in-differences analyses sterilizations vasectomies by age state policy; using open-text survey responses national MyVoice...
Abstract How IRF7 promotes autoimmune B cell responses and systemic autoimmunity is unclear. Analysis of spontaneous SLE-prone mice deficient in uncovered the role regulating germinal center (GC), plasma (PC) autoantibody disease. IRF7, however, was dispensable for foreign antigen driven GC, PC antibody responses. Competitive bone marrow (BM) chimeras highlighted importance hematopoietic cells GC differentiation. Single-cell-RNAseq indicated mediated differentiation through fates....
How IRF7 promotes autoimmune B cell responses and systemic autoimmunity is unclear. Analysis of spontaneous SLE-prone mice deficient in uncovered the role regulating germinal center (GC), plasma (PC), autoantibody disease. IRF7, however, was dispensable for foreign antigen–driven GC, PC, antibody responses. Competitive bone marrow (BM) chimeras highlighted importance hematopoietic cells GC PC differentiation. Single-cell RNAseq indicated IRF7-mediated differentiation through fates....
Abstract MicroRNAs (miRNAs) are involved in healthy B cell responses and the loss of tolerance systemic lupus erythematosus (SLE), although role many miRNAs remains poorly understood. Dampening miR-21 activity was previously shown to reduce splenomegaly blood urea nitrogen levels SLE-prone mice, but detailed cellular mechanism action unexplored. In this study, using TLR7 agonist, imiquimod-induced SLE model, we observed that Sle1b mice prevented formation plasma cells autoantibody-producing...
Abstract Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we uncovered a B cell intrinsic role for STAT3 in GC DZ LZ organization. Altered zonal organization STAT3-deficient GCs dampened output long-lived plasma cells (LL-PCs) but increased memory (MBCs). Tfh-GC interaction drive tyrosine 705 serine 727 phosphorylation cells, facilitating their recycling the DZ. An inducible system confirmed is not involved initiating or...
Abstract MicroRNAs (miRNAs) are involved in healthy B cell responses and the loss of tolerance systemic lupus erythematosus (SLE), though role many miRNAs remains poorly understood. Dampening miR-21 activity was previously shown to reduce splenomegaly blood urea nitrogen levels SLE-prone mice, but detailed cellular mechanism action unexplored. Herein, using TLR7 agonist imiquimod-induced SLE model, we observed that Sle1b mice prevented formation plasma cells autoantibody forming (AFC),...
Abstract MicroRNA-21 (miR-21) is upregulated in SLE patients and promotes disease multiple autoimmune mouse models; however, mechanisms by which miR-21 promote autoimmunity are unknown. Here we show that TLR7 overexpressing SLE-prone B6.Sle1b Yaamice deficient (Sle1b YaamiR-21 −/−) resisted development through reduced germinal center (GC) B cell, T follicular helper plasma cell responses. Sle1b −/−mice had serum autoantibody titers numbers of autoantibody-producing antibody forming cells...