A5024159764- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Behavioral Health and Interventions
- HIV/AIDS drug development and treatment
- Traffic and Road Safety
- Liver Disease Diagnosis and Treatment
- Bullying, Victimization, and Aggression
- HIV-related health complications and treatments
- Data-Driven Disease Surveillance
- Reliability and Agreement in Measurement
- Child Nutrition and Water Access
- Nuclear materials and radiation effects
- Sepsis Diagnosis and Treatment
- Non-Invasive Vital Sign Monitoring
- Urban Green Space and Health
- Forensic and Genetic Research
- Cancer survivorship and care
University of Liverpool
2025
Living Streets
2024
Children's Hospital of Philadelphia
2017-2019
Clinic for Special Children
2017
New York University
2017
The Wistar Institute
2011-2014
Boston University
2013
Ragon Institute of MGH, MIT and Harvard
2010-2011
Massachusetts Institute of Technology
2010
Wildfowl & Wetlands Trust
2010
Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells in early infection are associated with the dramatic decline of peak viremia, whereas their antiviral activity chronic is less apparent. The functional properties accounting for HIV-1-specific during unclear. Using cytokine secretion and tetramer decay assays, we demonstrated intraindividual comparisons that avidity was consistently higher than presence high-level viral replication. This change T-cell between infections linked...
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ cells. However, very little is known about impact cytotoxic lymphocyte (CTL) epitope mutations on interactions between peptide–major histocompatibility complex (MHC) class I complexes and MHC receptors expressed other types. Here, we analyzed a variant immunodominant human leukocyte antigen (HLA)-B2705–restricted HIV-1 Gag KK10 (KRWIILGLNK) with an L to M amino acid substitution at...
The relative contributions of HLA alleles and T-cell receptors (TCRs) to the prevention mutational viral escape are unclear. Here, we examined human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) responses restricted by two closely related class I alleles, B*5701 B*5703, that differ amino acids but both associated with a dominant response same HIV-1 Gag epitope KF11 (KAFSPEVIPMF). When this is presented HLA-B*5701, it induces TCR repertoire highly conserved among individuals,...
Antiviral Abs, for example those produced in response to influenza virus infection, are critical neutralization and defense against secondary infection. While the half-life of Abs is short, Ab titers can last a lifetime due subset Ab-secreting cells (ASCs) that long lived. However, mechanisms governing ASC longevity poorly understood. Here, we have identified role extrinsic cytokine signals survival respiratory tract ASCs mouse model Irradiation mice at various time points after infection...
Background The extracellular domain of the influenza A virus protein matrix 2 (M2e) is remarkably conserved between various human isolates and thus a viable target antigen for universal vaccine. With goal inducing protection in multiple mouse haplotypes, M2e-based antigenic peptides (M2e-MAP) were synthesized to contain promiscuous T helper determinants from Plasmodium falciparum circumsporozoite protein, hepatitis B hemagglutinin. Here, we investigated nature M2e-MAP-induced cell response...
ABSTRACT Pathogen-specific antibodies (Abs) protect against respiratory infection with influenza A virus (IAV) and Streptococcus pneumoniae are the basis of effective vaccines. Sequential or overlapping coinfections both pathogens common, yet impact coinfection on generation maintenance Ab responses is largely unknown. We report here that B cell response to IAV altered in mice coinfected S. this differs, depending order pathogen exposure. In exposed prior IAV, initial virus-specific germinal...
Background: The Self-Regulation Model (SRM) has been presented as a framework for assessing the perceptions people hold about their mental health problem. Currently no direct attempts have made to assess association between illness and engagement in psychosis. Engagement is an important issue professionals providing support with psychosis; therefore, research demonstrating link may enable targeted interventions facilitate enhance outcome. Aim: To whether beliefs are associated...
Recent studies suggest that innate immune responses by natural killer (NK) cells play a significant role in restricting human immunodeficiency virus type-1 (HIV-1) pathogenesis. Our aim was to characterize changes NK associated with HIV-1 clade C disease progression. Here we used multiparametric flow cytometry (LSRII) quantify phenotype and function of cross-sectional analysis cryopreserved blood samples from cohort 41 chronically HIV-1-infected, treatment-naive adult South Africans. These...
A healthy lifestyle is associated with improved quality of life among cancer survivors, yet adherence to health behavior recommendations low.This pilot trial developed and tested the feasibility a tailored eHealth program increase fruit vegetable consumption physical activity older, long-term survivors.American Cancer Society (ACS) guidelines for survivors were translated into an interactive, on basis Social Cognitive Theory. Patients (N=86) history breast (n=83) or prostate (n=3) less than...
Abstract Combination antiretroviral therapy (cART) prevents HIV-1 replication but does not eliminate the latent reservoir and cure infection. Type I interferons (IFN) mediate antiviral effects through different mechanisms than cART. We previously showed that IFNα14 is most potent IFNα subtype against it can significantly reduce proviral reservoir. This study sought to determine whether combining cART with would produce greater reductions in viral loads ART alone. Immunodeficient Rag2 −/− γ c...
HLA-A3 and -A11 share similar peptide-binding motifs, however, it is unclear if promiscuous epitope presentation by or HLA-A11 associated with TCR recognition. Here, we show that despite widespread cross-presentation of identical HIV-1 peptides in HIV-1-infected individuals expressing HLA-A11, presented commonly exhibited clear immune distinctiveness exclusive Yet, using tetramers for testing T cell cross-recognition the Nef QK10 epitope, observed two study persons specific CD8+ populations...
Background Induction of HIV-1–specific CD4+ T-cell responses by therapeutic vaccination represents an attractive intervention to potentially increase immune control HIV-1. Methods We performed a double-blinded, randomized, placebo-controlled clinical trial determine the safety and immunogenicity GlaxoSmithKline Biologicals' HIV-1 gp120/NefTat subunit protein vaccine formulated with AS02A Adjuvant System in subjects well-controlled chronic infection on highly active antiretroviral therapy....
Emergency medicine physicians and their staff care for high-risk injured patients, making the emergency department (ED) an appropriate place to discuss injury prevention (IP).To determine family receptiveness short-term effectiveness of IP information delivery during ED visit.A cross-sectional survey was conducted in urban pediatric ED. Caregivers children younger than 15 years, with any chief complaint, were approached participate. The consisted caregiver's background, received by primary...
Human immunodeficiency virus type 1 (HIV-1) cytotoxic T-lymphocyte escape mutations represent both a major reason for loss of HIV immune control and considerable challenge HIV-1 vaccine design. Previous data suggest that initial HIV-1-specific CD8(+) T-cell responses are determined largely by viral host genetics, but the mechanisms influencing subsequent evolution unclear. Here, we show random recruitment receptor (TCR) alpha beta clonotypes T cells during primary infection in two...
Telomerase activity in HIV-1-specific CD8(+) T cells from controllers contributes to the maintenance of highly functional cytotoxic cell responses against HIV-1. Here, we show that high expression telomerase is associated with hypermethylation at distal and hypomethylation proximal human catalytic subunit promoter, whereas progressors showed an inverse pattern promoter hypermethylation. These data suggest distinct epigenetic signatures controllers.