A5054575625- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Dialysis and Renal Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood properties and coagulation
- Hemophilia Treatment and Research
- Acute Myocardial Infarction Research
- SARS-CoV-2 and COVID-19 Research
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Renal Diseases and Glomerulopathies
- Advanced Glycation End Products research
- Blood groups and transfusion
- Viral Infections and Immunology Research
- Cardiovascular Health and Risk Factors
- Antioxidant Activity and Oxidative Stress
- Diabetes Treatment and Management
Fujita Health University Hospital
2021-2025
Fujita Health University
2021-2024
Abstract Background Ethylenediamine tetraacetate/glycine acid (EGA) and chloroquine diphosphate (CDP) are used in transfusion testing to dissociate IgG antibodies from red blood cells (RBCs). However, the ability of these reagents IgM sensitized RBCs has not been comprehensively elucidated. We investigated whether EGA CDP could cold‐reactive their effect on after dissociation treatment. Study Design Methods Cold‐reactive antibody‐sensitized RBC samples were prepared by mixing group A B...
<h3>Importance</h3> The associations of levels diverse serum carotenoids ascertained via repeated measurements with all-cause, cancer, and cardiovascular disease (CVD) mortality risk have not been considered in previous prospective studies. <h3>Objective</h3> To investigate the association between measurement carotenoid all-cause cause-specific risk. <h3>Design, Setting, Participants</h3> This cohort study's baseline data were collected using information from physical examinations 1990 to...
Background: Thioredoxin-interacting protein (TXNIP) controls the cellular redox balance by binding to and inhibiting expression function of thioredoxin. DNA methylation TXNIP gene is involved in regulation mRNA expression. Changes levels are associated with development various diseases such as type 2 diabetes mellitus (T2DM). However, few studies have focused on influence lifestyle factors alcohol intake methylation.Objectives: This research examines association drinking behaviors general...
Previous studies have proposed different formulas of estimating glomerular filtration rate (eGFR) among clinical patients. The comprehensive comparison eGFR is not well established in a Japanese population. We compared values and chronic kidney disease (CKD) classification nine general population sample.We analyzed 469 community-dwelling adults (184 men) without any self-reported disease. GFR estimated using the 4- 6-parameter Modification Diet Renal Disease (MDRD) (MDRD4 MDRD6); CKD-EPI...
Objectives We evaluated the applicability of a machine learning–based low-density lipoprotein-cholesterol (LDL-C) estimation method and influence characteristics training datasets. Methods Three datasets were chosen from datasets: health check-up participants at Resource Center for Health Science ( N = 2664), clinical patients Gifu University Hospital 7409), Fujita 14,842). Nine different learning models constructed through hyperparameter tuning 10-fold cross-validation. Another test dataset...
Abstract The renal angina index (RAI) is a validated scoring tool for predicting acute kidney injury (AKI). We investigated the efficacy of RAI in 2436 heterogeneous patients (mean age, 70 years) treated cardiac intensive care units (CICUs). was calculated from creatinine and patient condition scores. AKI diagnosed by Kidney Disease: Improving Global Outcome criteria. primary secondary endpoints were development severe all-cause mortality, respectively. Four hundred thirty-three developed...
Thioredoxin-interacting protein (TXNIP) plays an important role in glucose metabolism, and its expression is regulated by DNA methylation (DNAm). Although the association between TXNIP DNAm type 2 diabetes mellitus has been demonstrated studies with a cross-sectional design, prospective are needed. We therefore examined levels longitudinal changes glycemic traits conducting study involving 169 subjects who underwent two health checkups 2015 2019. used pyrosequencing assay to determine...
The CHA2DS2 -VASc score is a vital clinical tool for evaluating thromboembolic risk in patients with atrial fibrillation (AF). This study investigated the efficacy of cohort 737 heterogeneous (mean age: 63 years) receiving care cardiac intensive units (CICUs), creatinine-based estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 upon admission and discharge. Incident chronic kidney disease (CKD) was defined as emergence new-onset eGFR<60 m2, accompanied by decline >5 compared to...
Preexisting cardiovascular disease (CVD) is a pivotal risk factor for severe coronavirus 2019 (COVID-19). We investigated the longitudinal (over 1 year and 9 months) humoral cellular responses to primary series booster doses of mRNA COVID-19 vaccines in patients with CVD. Twenty-six CVD who received monovalent were enrolled this study. Peripheral blood samples serially drawn nine times from each patient. IgG against acute respiratory syndrome 2 (SARS-CoV-2) spike receptor-binding domain...
Activated partial thromboplastin time (APTT) is susceptible to reagent composition. This study aimed investigate a large number of specimens and determine the cause discrepancies.
Acute heart failure is an important cause of unplanned hospitalizations and poses a significant burden through increased mortality frequent hospitalizations. Heart with preserved ejection fraction (HFpEF) presents as diverse condition characterized by complex cardiovascular non-cardiovascular pathology. This study aimed to identify distinct clinical phenotypes in acute decompensated HFpEF (ADHF) using cluster analysis assess their prognostic significance. We applied latent class 1,281 ADHF...
Background: The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) has become a global health problem. NAFLD few initial symptoms and may be difficult to detect early, so there is need for minimally invasive early detection marker. We hypothesized that miR-122 miR-20a levels combined, as the miR-122/miR-20a ratio might more sensitively. Methods: This study involved 167 participants with low alcohol intake. Those who had an increase in echogenicity parenchyma hepato-renal...
High concentrations of low-density lipoprotein cholesterol (LDL-C) are a risk factor for cardiovascular disease. We validated the efficacy Martin method is useful in estimation LDL-C was Japanese populations and derived modified easy laboratory information system applications.We created 3 subject groups, including 2664 health check-up participants registered with Resource Center Health Science, 29,806 clinical patients (A) Gifu University Hospital, 113,716 (B) Fujita Hospital. Each to...
Abstract Background Although dementia is a huge problem in public health, no fundamental biomarker has been established to detect cognitive decline at the early stage. MicroRNAs (miRNAs) regulate gene expression, and are associated with development of various diseases. Methods The subjects this prospective study were 162 (75 men, 87 women) residents who attended health examination Yakumo town Hokkaido, 2012 re-attended least once while 2013 2015. Serum samples collected serum miRNA measured...
BACKGROUND: Hemoglobin A1c (HbA1c), which is one of the important parameters considered when judging degree glucose concentrations during preceding 8–12 weeks, used as standard assessment glycemic control in patients with diabetes. However, some measurement principles may cause errors HbA1c measurement. CASE REPORT: A 49-year-old male patient hyperglycemic hyperosmotic syndrome had an extreme high blood level 2,161 mg/dL and that was not measurable due to a large amount labile HbA1c. Many...