A5057907361- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Vascular Anomalies and Treatments
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Potassium and Related Disorders
- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Cerebrovascular and Carotid Artery Diseases
Hospital Universitario 12 De Octubre
2018-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2019-2025
Spanish National Centre for Cardiovascular Research
2018-2025
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2022-2025
Lung Institute
2023-2025
Université Laval
2022-2025
Centro de Investigación Biomédica en Red
2019-2024
Montreal Heart Institute
2024
Universidad Complutense de Madrid
2019-2023
Research Institute Hospital 12 de Octubre
2017-2022
Abstract Aims Valve durability becomes a major issue as transcatheter aortic valve implantation (TAVI) is expanding to populations with longer life expectancy. We sought i) determine the incidence of structural deterioration (SVD), ii) compare SVD between balloon-expandable (BE) and self-expandable (SE) valves, iii) analyze impact SVD. Methods Results 2040 patients who underwent TAVI (2007-2020) from 9 centers were included. After inverse probability treatment weighting (IPTW), 1848 selected...
Background: Poor natriuresis has been associated with a poorer response to diuretic treatment and worse prognosis in acute heart failure. Recommendations on how when measure urinary sodium (UNa) are lacking. We aim evaluate UNa quantification after furosemide stress test (FST) capacity predict appropriate decongestion during failure hospitalization. Methods: Patients underwent an FST day-1 of admission, was measured 2 hours after, dividing patients into low or high based the sample median...
Abstract Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy PH. To separate effect overload from other potential we developed pigs two experimental models PH (M1, by vein banding and M2, aorto-pulmonary shunting) compared them a model pure (M3, artery banding) sham-operated group. Animals were assessed at 1 8 months right...
Background: Noninvasive techniques for diagnosing combined postcapillary pulmonary hypertension (CpcPH) are unavailable. Objective: To assess the diagnostic performance of cardiac magnetic resonance (CMR)-based four-dimensional (4D)-flow analysis in identifying CpcPH. Methods: Prospective observational study heart failure (HF) patients with suspected (PH) who underwent simultaneous CMR and right catheterization. The 4D-flow biomarkers were calculated using an automatic pipeline. A predictive...
The utility of the human epididymis protein 4 (HE4) in patients undergoing transcatheter aortic valve implantation (TAVI) has not been established yet. present study aimed at examining prognostic value HE4 TAVI. In this prospective study, to predict adverse clinical events was evaluated 362 who underwent association between and diffuse myocardial fibrosis also assessed using T1 mapping on cardiac magnetic resonance a subgroup 43 patients. During median follow-up 2.5 (IQR: 1.9-3.2) years,...
Pulmonary hypertension (PH) associated with left heart disease is an increasingly prevalent problem, orphan of targeted therapies, and related to a poor prognosis, particularly when pre- post-capillary PH combine. The current study aimed determine whether treatment the selective β3 adrenoreceptor agonist mirabegron improves outcomes in patients combined (CpcPH).The Adrenergic Agonist Treatment Chronic Hypertension Secondary Heart Failure (SPHERE-HF) trial multicentre, randomized, parallel,...
It is recommended to assess frailty prior heart transplantation (HT). Our objective was the prevalence of in patients listed for HT.The FELICITAR registry (Frailty Evaluation after List Inclusion, Characteristics and Influence on TrAnsplantation And Results) a prospective that includes HT three centers, from January 2017 April 2019. We assessed presence frailty, depression, cognitive impairment, quality life when included.Ninety-nine were included. Of this group, 30.6% frail, 55 (56.1%) had...
We sought to assess the clinical value of adding intravascular ultrasound (IVUS) evaluation coronary angiography (CA) guide extrinsic left main artery (LMCA) compression diagnosis and treatment in pulmonary hypertension (PH).LMCA due a aneurysm (PAA) is severe complication PH. Although guidelines encourage use IVUS for LMCA disease evaluation, it has hardly been used this scenario.We analyzed morbimortality type 1 4 PH patients with clinically suspected by PAA between 2010 2018 reference...
Abstract Primary percutaneous coronary intervention (PPCI) has dramatically changed the outcome of patients with ST-elevation myocardial infarction (STEMI). However, despite improvements in interventional technology, registry data show little recent change prognosis who survive STEMI, a significant incidence cardiogenic shock, heart failure, and cardiac death. Despite technically successful PPCI procedure, variable proportion experience suboptimal reperfusion. Large infarct size...
A blood multimarker approach may be useful to enhance risk stratification in patients undergoing TAVI. The objective of this study was determine the prognostic value multiple biomarkers transcatheter aortic valve implantation (TAVI) patients. In prospective study, several cardiovascular function, inflammation, and renal function were measured 362 who underwent cohort divided into 3 groups according number elevated (ie, ≥median for whole cohort) each patient before procedure. Survival...