A5001965394- Cardiac Valve Diseases and Treatments
- COVID-19 Clinical Research Studies
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Long-Term Effects of COVID-19
- Genetic Associations and Epidemiology
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- SARS-CoV-2 and COVID-19 Research
- Williams Syndrome Research
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Pericarditis and Cardiac Tamponade
- Vasculitis and related conditions
- Inflammatory Myopathies and Dermatomyositis
- Nerve injury and regeneration
- Heart rate and cardiovascular health
- Respiratory Support and Mechanisms
- Renin-Angiotensin System Studies
- Sepsis Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
Royal North Shore Hospital
2020-2025
The University of Sydney
2019-2025
Imperial College London
2023-2024
Cooperative Trials Group for Neuro-Oncology
2024
Northern Sydney Local Health District
2021-2024
Oxford BioMedica (United Kingdom)
2020
University of Oxford
2020
Oxford University Hospitals NHS Trust
2019
The Heart Research Institute
2016
Elevated blood pressure, dyslipidemia, and impaired glycemic control are well-established cardiovascular risk factors in Europeans, but there comparatively few studies focused on East Asian populations. This study evaluated the potential causal relations between traditional disease Asians through a 2-sample Mendelian randomization approach. We collected summary statistics for pressure parameters, lipid subsets, type 2 diabetes mellitus liability from large genome-wide association...
Large observational studies have demonstrated a clear inverse association between renal function and risk of aortic stenosis (AS). Whether this represents causal, reverse causal or correlative relationship remains unclear. We investigated using bidirectional 2-sample Mendelian randomization approach.
Abstract There are currently no approved pharmacological treatment options for aortic stenosis (AS), and there limited identified drug targets this chronic condition. It remains unclear whether inflammation plays a role in AS pathogenesis immunomodulation could become therapeutic target. We evaluated the potentially causal association between by investigating genetically proxied effects of tocilizumab (IL6 receptor, IL6R, inhibitor), canakinumab (IL1β inhibitor) colchicine (β-tubulin through...
ObjectivesDescribe the incidence of cardiac complications in patients admitted to hospital with COVID-19 Australia.DesignObservational cohort study.SettingTwenty-one (21) Australian hospitals.ParticipantsConsecutive aged ≥18 years laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Main outcome measuresIncidence complications.ResultsSix-hundred-and-forty-four (644) hospitalised (62.5±20.1 yo, 51.1% male) were enrolled study. Overall in-hospital...
Abstract Primary percutaneous coronary intervention (PPCI) has dramatically changed the outcome of patients with ST-elevation myocardial infarction (STEMI). However, despite improvements in interventional technology, registry data show little recent change prognosis who survive STEMI, a significant incidence cardiogenic shock, heart failure, and cardiac death. Despite technically successful PPCI procedure, variable proportion experience suboptimal reperfusion. Large infarct size...
Traditional prognostic models for ST-segment elevation myocardial infarction (STEMI) have limitations in statistical methods and usability.
Hydrophobins are remarkable proteins due to their ability self-assemble into amphipathic coatings that reverse surface wettability. Here, the versatility of Class I hydrophobins EASΔ15 and DewY in diverse nanosuspension coating applications is demonstrated. The shown coat or emulsify a range substrates including oil, hydrophobic drugs, nanodiamonds alter solution behavior. Surprisingly, while confer new properties, only subset found be resistant hot detergent treatment, feature previously...
Objective To assess whether hypertension is an independent risk factor for mortality among patients hospitalised with COVID-19, and to evaluate the impact of ACE inhibitor angiotensin receptor blocker (ARB) use on in a background hypertension. Method This observational cohort study included all index hospitalisations laboratory-proven COVID-19 aged ≥18 years across 21 Australian hospitals. Patients suspected, but not were excluded. Registry data analysed in-hospital comorbidities including...
Abstract Background Aortic stenosis (AS) may prolong atrioventricular (AV) conduction secondary to calcium infiltration of the atrioventricular-His-pathway, which is hypothesized contribute bradyarrhythmia and sudden cardiac death in this cohort. This study investigates correlation between calcific AS impaired AV conduction. Methods We performed an observational Mendelian randomization (MR). The was a sub-analysis on patients undergoing transcatheter aortic valve implantation2021-2023)....
Introduction: Large observational and Mendelian randomization (MR) studies have demonstrated a strong association between elevated triglycerides (TG) risk of aortic stenosis (AS). However, at present there remains no evidence for the use lipid-lowering therapies to prevent or treat AS. To address this gap, we used drug target MR approach investigate whether emerging TG lowering may reduce Methods: We collected summary statistics levels AS from genome-wide including 1,253,277 653,867 European...
Abstract Introduction Large observational and Mendelian randomization (MR) studies have demonstrated a strong association between both elevated LDL cholesterol (LDL-c) triglycerides (TG) with risk of aortic stenosis (AS), although randomized trials showed no benefit statins for AS. It consequently remains uncertain whether lipid-lowering therapies role to prevent or treat We used drug-target MR approach investigate the genetically predicted effect on Methods results collected summary...