Azithromycin exposure has been reported to increase the risk of QT prolongation and cardiovascular death. However, findings on association between azithromycin death are controversial, is still used in actual practice. Additionally, quantitative assessments have not performed, including when patients exposed a real-world clinical setting. Therefore, this study, we aimed evaluate setting using 21-year medical history database tertiary institution.We analyzed electrocardiogram results relevant...

Abstract Background Sleep disturbance has been significantly associated with the incidence of cardiovascular disease (CVD) in general population. However, despite common prevalence sleep patients type 2 diabetes, its relationship risk CVD remains unclear. Here, we have examined association all and all-cause mortality newly-diagnosed diabetes. Methods We used Korean National Health Insurance Service–Health Screening Cohort data included 36,058 new-onset diabetes aged ≥ 40 years between 2004...

Previous evidence suggests that there is a correlation between prolonged sitting time and cardio-metabolic disease, such as metabolic syndrome (MS). Cardiovascular disease the second-leading cause of mortality in South Korea, country with longest working hours among all member states Organization for Economic Co-operation Development. However, no previous study has investigated relationships overall sitting-time occupation MS Korea. Accordingly, present examined these Korean population. Data...

Background The importance of identifying and evaluating adverse drug reactions (ADRs) has been widely recognized. Many studies have developed algorithms for ADR signal detection using electronic health record (EHR) data. In this study, we propose a machine learning (ML) model that enables accurate by integrating features from existing based on inpatient EHR laboratory results. Materials methods To construct an reference dataset, extracted known drug–laboratory event pairs represented test...

The aim of this study was to examine factors associated with the use mental health consultation for depressive symptoms.We used data from 2013 Community Health Survey, which included responses 13,269 individuals who reported that they had experienced symptoms more than 2 weeks in Korea. We investigated associations between rates and sociodemographic, socioeconomic, health-related factors. Logistic regression analysis significance associations.Among participants report symptoms, 16.0% (n =...

Abstract Exposure to PM2.5 (particulate matter <2.5 μm) has been implicated in increasing the risk of endometriosis and worsening its symptoms. However, molecular mechanisms direct associations remain unclear. This study explored whether contributes onset or progression using vitro vivo models. Endometrial (EM) cells from women without were cultured second passages (P2) with exposure at a concentration 200 µg/mL (N = 5 for each group). Z-stack confocal imaging confirmed PM...

Gout is a chronic disease associated with deposition of monosodium urate crystals and accompanied by diabetes, hypertension, dyslipidemia. Hypertriglyceridemia common among patients gout, fenofibrate usually used to reduce triglyceride levels. The aim this study determine the effect uric acid reduction in gout administered lowering agents (viz., xanthine oxidase inhibitors allopurinol febuxostat). Data from 863 were collected electronic medical records comprising information on underlying...

The literature on stroke mortality and neighborhood effect is characterized by studies that are often Western society-oriented, with a lack of racial cultural diversity. We estimated the cross-level interaction between individual regional socioeconomic status survival after onset ischemic stroke.We selected newly diagnosed patients from 2002 to 2013 using stratified representative sampling data 1,025,340 subjects. A total 37,044 over 10 years 2004 had stroke. calculated hazard ratios (HR)...

The aim of this study is to examine the association between parental socioeconomic status (SES) and experience as well treatment dental caries among children aged 9 18 years.Data from 1253 9-18 years Korean National Health Nutrition Examination Survey (2012-2013) were analyzed. Parental was measured using household income level maternal educational level. decayed, missing, filled teeth (DMFT) index used measure (DMFT ≥ 1). Non-treatment according whether participants who experienced a...

We investigated the association of changes in frequency moderate-to-vigorous physical activity (MVPA) and risks all-cause cardiovascular disease (CVD) mortality. This study used nationally representative National Health Insurance Service-National Sample Cohort database. included 286,402 individuals aged ≥20 years estimated MVPA over a two-year period. Hazard ratios (HRs) 95% confidence intervals (CIs) were calculated using Cox proportional hazard regression models. The HRs (95% CIs) for risk...

ObjectiveTo determine whether patients with greater continuity of care (COC) have fewer preventable hospitalizations.

The objective of this study was to investigate the impact social engagement and patterns change in over time on mortality a large population, aged 45 years or older. Data from Korean Longitudinal Study Aging 2006 2012 were assessed using longitudinal data analysis. We included 8,234 research subjects at baseline (2006). primary analysis based Cox proportional hazards models examine our hypothesis. hazard ratio all-cause for lowest level 1.841-times higher (P < 0.001) compared with highest...

Objective The present study aimed to determine whether the suicide risk increased after a cancer diagnosis. Design Population-based cohort study. Setting and participants This incorporated National Health Insurance Service-National Sample Cohort in South Korea. Of 975 348 subjects, 39 027 with 936 321 who were free participated between 2005 2013. Primary outcome measure Suicide. Results A total of 110 suicides (82 men, 28 women) identified among these subjects during 127 184 person-years;...

Hearing loss in the elderly causes communication difficulties, decreased quality of life, isolation, loneliness and frustration. The aim this study was to identify modifiable variables that may affect progression hearing elderly. A case-control conducted using two data sets. Data were extracted from health examination survey Ajou University Hospital (2010-2014) Korea National Health Nutrition Examination Survey (2009-2012) Audiometry evaluated according such as age, sex drug use for...

Abstract Objectives The objective of this study was to identify the association between continuity ambulatory psychiatric care after hospital discharge among patients and readmission, mortality suicide. Design Nationwide nested case-control study. Settings South Korea. Participants Psychiatric inpatients. Interventions Continuity outpatient measured from time until readmission or death occurred, using index. Main Outcome Measures Readmission, all-cause suicides within 1-year post-discharge....

Stroke is frequently associated with readmission; moreover, readmission regarded as an important indicator of the quality stroke care. Thus, we investigated factors 30-day in patients South Korea. We used claims data from 2013 for (I60-I62) (n=44 729) 94 hospitals and classified unplanned according to Centers Medicare Medicaid guidelines. multilevel models investigate patient (age, gender, type insurance, admission via emergency room, length stay, stroke, Elixhauser Index Score) hospital...

To investigate relationships among neonatal hypothyroidism, family income, and intellectual disability, as well the combined effects of hypothyroidism low income on disability.Data were extracted from National Health Insurance Service-National Sample Cohort 2002 to 2011. This retrospective study included 91,247 infants. The presence disability was based evaluation system in Korea. Newborn identified diagnosis prescription codes. Family determined average monthly insurance premiums. Cox...

The socioeconomic status of a person has an impact on his or her access to kidney transplantation as been reported in western countries. This study examined the association between income level and among chronic disease patients undergoing dialysis South Korea.We analyzed data from 1,792 listed Korean National Health Insurance Claim Database (2003-2013). likelihood receiving first transplant over time was using competing risk proportional hazard models initiating transplant.Of dialysis, only...

This study aims to determine whether significant associations exist between the parents' country of birth and adolescent depressive symptoms in early stages a multicultural society.We used data from 2012-2016 Korea Youth Risk Behavior Web-based Survey, which included responses 327,357 individuals. Participants were classified into groups according their parent's birth. Logistic regression analysis was examine significance associations.Adolescents whose parents born abroad are more likely...

To investigate the effects of household income level on all-cause mortality in patients with Alzheimer's disease (AD). Data was obtained from 7,937 participants Korean National Health Insurance cohort who newly diagnosed using anti-dementia medication between 2003 and 2013. All individuals were followed-up until December 2013 or death, whichever came first. Individual estimated national health insurance premium. Information Statistical Office. Cox proportional hazard models used to compare...

<title>Abstract</title> Plastics have become an integral part of human life, and their production is increasing annually. are broken down into small particles known as microplastics (MPs) with particle size &lt; 5 mm in the environment because a variety factors. MPs prevalent all living organisms exposed to effects. In this study, we investigated whether polystyrene (PS)-MPs were transferred from cell-to-cell via extracellular vesicles (EVs). This study showed that cell-derived EVs could...

Updated reports on the population-based analysis of atopic dermatitis (AD) in Korea are rare. This study aimed to investigate nationwide prevalence and systemic medication prescription trends AD Korea.