A5077805284- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infrared Thermography in Medicine
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Lymphatic System and Diseases
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Brain Metastases and Treatment
- Respiratory Support and Mechanisms
- Leprosy Research and Treatment
- Medical Imaging and Pathology Studies
- Autophagy in Disease and Therapy
- Hematological disorders and diagnostics
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- Clusterin in disease pathology
- Metabolism, Diabetes, and Cancer
- Eosinophilic Disorders and Syndromes
- Metabolomics and Mass Spectrometry Studies
- Bone and Joint Diseases
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
Weill Cornell Medicine
2020-2024
Presbyterian Hospital
2014-2024
Cornell University
2014-2024
NewYork–Presbyterian Hospital
2014-2023
New York Hospital Queens
2014-2023
Penn Presbyterian Medical Center
2020
Virginia Commonwealth University
2007-2010
Radiation Oncology Institute
1994
Istituto Oncologico Veneto
1990
Istituto Tumori Bari
1990
Abstract Pemetrexed represents the first antifolate cancer drug to be approved by Food and Drug Administration in 20 years; it is currently widespread use for line therapy of mesothelioma non–small cell lung cancer. has more than one site action; primary thymidylate synthase. We now report that secondary target downstream folate-dependent enzyme de novo purine synthesis, aminoimidazolecarboxamide ribonucleotide formyltransferase (AICART). The substrate AICART reaction, ZMP, accumulated...
Chronic obstructive pulmonary disease (COPD) is marked by airway inflammation and airspace enlargement (emphysema) leading to airflow obstruction eventual respiratory failure. Microvasculature dysfunction associated with COPD/emphysema. However, it not known if abnormal endothelium drives COPD/emphysema pathology and/or correcting endothelial has therapeutic potential. Here, we show the centrality of cells pathogenesis in human tissue using an elastase-induced murine model emphysema....
Abstract The chemotherapeutic drug pemetrexed, an inhibitor of thymidylate synthase, has important secondary target in human leukemic cells, aminoimidazolecarboxamide ribonucleotide formyltransferase (AICART), the second folate-dependent enzyme purine biosynthesis. intermediate (ZMP), which accumulates behind this block, transmits inhibitory signal to mTORC1 complex via activation cellular energy sensor AMP-activated kinase (AMPK). Given that PI3K-AKT-mTOR pathway is frequently deregulated...
Background Right ventricular (RV) maladaptation to elevated pulmonary afterload is the primary determinant of outcomes in artery (PA) hypertension; however, pathobiological mechanisms underlying RV decompensation remain poorly understood. Methods We performed global untargeted metabolomics on plasma from 55 patients who underwent gold‐standard RV‐PA coupling measurements using multibeat pressure volume loop assessment a single‐center cohort and 1027 with surrogate larger multicenter cohort,...
Abstract As antimicrobial resistance increases, understanding the current epidemiology of bloodstream infections (BSIs) in hematopoietic stem cell transplant (HSCT) recipients is essential to guide empirical therapy. We therefore reviewed microbial etiologies, timing and outcomes BSIs patients who were transplanted from September 2007 December 2011. Vancomycin-resistant enterococci (VRE) most common pathogens allogeneic HSCT fourth after autologous transplant. VRE did not cause any 101...
The coronavirus disease-19 (COVID-19) pandemic has ravaged global healthcare with previously unseen levels of morbidity and mortality. In this study, we performed large-scale integrative multi-omics analyses serum obtained from COVID-19 patients the goal uncovering novel pathogenic complexities disease identifying molecular signatures that predict clinical outcomes. We assembled a network protein-metabolite interactions through targeted metabolomic proteomic profiling in 330 compared to 97...
Abstract The lymphatic vasculature is critical for lung function, but defects in function the pathogenesis of disease understudied. In mice, dysfunction alone sufficient to cause injury that resembles human emphysema. Whether disrupted cigarette smoke (CS)-induced emphysema unknown. this study, we investigated effect CS on function. Analysis tissue revealed significant thrombosis patients with compared control smokers increased severity. a mouse model, exposure led thrombosis, decreased...
This report aims to characterize the kinetics of serum albumin in critically ill patients with coronavirus disease 2019 compared sepsis-induced acute respiratory distress syndrome.Retrospective analysis.We analyzed two cohorts, one and another syndrome, treated New York Presbyterian Hospital-Weill Cornell Medical Center.Adult cohort, diagnosed through reverse transcriptase-polymerase chain reaction assays performed on nasopharyngeal swabs, were admitted from March 3, 2020, July 10, 2020....
The mouse fpgs gene uses two distantly placed promoters to produce functionally distinct isozymes in a tissue-specific pattern. We queried how the P1 and P2 were differentially controlled. DNA methylation of CpG-sparse promoter occurred only tissues not initiating transcription at this site. promoter, which was embedded CpG island, appeared open all by several criteria, including lack methylation, yet used dividing tissues. patterns histone modifications over very different: P1, activation...
Pulmonary Hypertension (PH) is a known complication of myeloproliferative neoplasms (MPN) with estimated prevalence as high 50%. Patients Polycythemia Vera (PV) report wide spectrum symptoms that significantly overlap those reported by patients PH. Yet, it not how PH affects outcomes and survival in PV. To address this gap, we investigated the impact echocardiogram (ECHO) risk on PV from our large single center cohort. Of 637 PV, 134 had at least one ECHO were included for analysis. Overall...
Introduction: Efforts to stratify mortality risk in pulmonary hypertension (PH) have focused on the minority of patients WSPH group 1. Metabolomic studies 1 identify histidine, polyamines, tRNA metabolites, and homoarginine as predictors mortality. Little is known about role metabolomics predict larger PH patients. Question: Which serum metabolites a composite or transplant pre-capillary, post-capillary, combined pre- post-capillary (Cpc-PH), irrespective group? Aims: To predictive Pulmonary...
Synopsis: Obesity is a major risk factor for OSA. The study by Ng and colleagues assessed the impact of weight loss reduction through lifestyle modification program on patients with moderate to severe They found in OSA severity daytime sleepiness that was directly associated loss. Source: SS, Chan RS, Woo J, TO, Cheung BH, Sea MM, To KW, KK, Ngai Yip WH, Ko FW, Hui DS. A randomized controlled examine effect Chest. 2015; 148(5):1193–1203.
ABSTRACT Vascular injury is a menacing element of acute respiratory distress syndrome (ARDS) pathogenesis. To better understand the role vascular in COVID-19 ARDS, we used lung autopsy immunohistochemistry and blood proteomics from subjects at distinct timepoints disease pathogenesis, including hospitalized cohort risk ARDS development (“ risk” , N=59), an intensive care unit with ( “ARDS ”, N=31), recovering recovery N=12). tissue revealed association between platelet-rich microthrombi....
Abstract The novel coronavirus disease-19 (COVID-19) pandemic caused by SARS-CoV-2 has ravaged global healthcare with previously unseen levels of morbidity and mortality. To date, methods to predict the clinical course, which ranges from asymptomatic carrier critically ill patient in devastating multi-system organ failure, have yet be identified. In this study, we performed large-scale integrative multi-omics analyses serum obtained COVID-19 patients goal uncovering pathogenic complexities...