A5010655923- Fluoride Effects and Removal
- Bone and Dental Protein Studies
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Anesthesia and Neurotoxicity Research
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Neutropenia and Cancer Infections
- Circular RNAs in diseases
- IL-33, ST2, and ILC Pathways
- Folate and B Vitamins Research
- Histone Deacetylase Inhibitors Research
- Dental Health and Care Utilization
- Cancer-related Molecular Pathways
- Dental Erosion and Treatment
- Lymphatic System and Diseases
- Ocular Oncology and Treatments
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Glioma Diagnosis and Treatment
- Dental Radiography and Imaging
- Lymphatic Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Cystic Fibrosis Research Advances
- Immune Response and Inflammation
Cornell University
2022-2024
Weill Cornell Medicine
2022-2024
Helmholtz Zentrum München
2021-2022
Lander Institute
2022
Universidade de São Paulo
2016-2021
Ludwig-Maximilians-Universität München
2021
Newcastle University
2017
COMSATS University Islamabad
2013
Day General Hospital
2011
The lymphatic fluid is the conduit by which part of tissue "omics" transported to draining lymph node for immunosurveillance. Following cannulation pre-nodal cervical and mesenteric afferent lymphatics, herein we investigate proteomic composition, uncovering that its composition varies according origin. Tissue specificity also reflected in dendritic cell-major histocompatibility complex class II-eluted immunopeptidome harvested from nodes. inflammatory disruption gut barrier, antigenic loads...
Cystatin B was recently identified as an acid-resistant protein in acquired enamel pellicle; it could therefore be included oral products to protect against caries and erosion. However, human recombinant cystatin is very expensive, alternatives its use are necessary. Phytocystatins reversible inhibitors of cysteine peptidases that found naturally plants. In plants, they have several biological physiological functions, such the regulation endogenous processes, defense pathogens, response...
Since 2020 SARS-CoV-2 spreads pandemically, infecting more than 119 million people, causing >2·6 fatalities. Symptoms of infection vary greatly, ranging from asymptomatic to fatal. Different populations react differently the disease, making it very hard track spread in a population. Measuring specific anti-SARS-CoV-2 antibodies is an important tool assess or successful vaccinations. To achieve sufficient sample numbers, alternatives venous blood sampling are needed not requiring medical...
Cell communication via exosomes is capable of influencing cell fate in stress situations such as exposure to ionizing radiation. In vitro and vivo studies have shown that might play a role out-of-target radiation effects by carrying molecular signaling mediators damage, well opposite protective functions resulting resistance radiotherapy. However, global understanding their radiation-induced regulation, especially within the context an intact mammalian organism, has been lacking. this study,...
Abstract The lymphatic vasculature is critical for lung function, but defects in function the pathogenesis of disease understudied. In mice, dysfunction alone sufficient to cause injury that resembles human emphysema. Whether disrupted cigarette smoke (CS)-induced emphysema unknown. this study, we investigated effect CS on function. Analysis tissue revealed significant thrombosis patients with compared control smokers increased severity. a mouse model, exposure led thrombosis, decreased...
Abstract Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across gastric intestinal epithelia. Previous studies have reported adverse gastrointestinal effects high levels exposure. Here, we examined on transepithelial ion transport resistance three We used Caco‐2 cell line as a model human epithelium, rat mouse colonic epithelia for purposes comparison. caused...
In this study, we investigated the differential pattern of protein expression in liver these mice to provide insights on why they have different responses F.Weanling male A/J and 129P3/J (n=10 from each strain) were pared housed metabolic cages with ad libitum access low-F food deionized water for 42 days. Liver proteome profiles examined using nLC-MS/MS. Protein function was classified by GO biological process (Cluego v2.0.7 + Clupedia v1.0.8) protein-protein interaction network constructed...
The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation. Acetylation Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance cell cycle control and tumorigenesis still unknown. Efforts are underway to investigate possible interplay between phosphorylation acetylation. Here we hypothesized that acetylation, like p53 may play a role development the tumor phenotype. proposed hypothesis regarding acetylation VS...
The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for tumors. critical role of the hippocampus pathogenesis radiation-induced neurocognitive dysfunction is well recognized. goal this study to test potential contribution non-targeted effects detrimental response irradiation and elucidate mechanisms involved. C57Bl/6 mice were whole body (WBI) or partial (PBI) irradiated with 0.1 2.0 Gy X-rays sham irradiated. PBI consisted lower...
Abstract The lymphatic fluid is the conduit by which part of tissue “omic’ transported to draining lymph node for immunosurveillance. Following cannulation pre-nodal cervical and mesenteric afferent lymphatics we analyzed proteomic composition determined that its specificity reflected in dendritic cell-MHCII-eluted immunopeptidome harvested from or nodes respectively. Additionally, since drains directly underlying intestinal barrier, performed same analysis following inflammatory disruption...
Background: Qualea grandiflora (QG) (Vochysiaceae), also known as "pau-ferro", "pau-terra" or "pau-de-tucano", is a very common deciduous tree in the Brazilian Cerrado used traditional medicine to treat inflammations, ulcers, diarrhea, and infections. There are reports scientific literature that demonstrate medicinal effects of bark leaf QG. However, studies involving this plant rather imited. Aim study: To perform phytochemical analysis QG hydroalcoholic extract (HAE) leaves, investigate it...