A5088225687- Reproductive tract infections research
- Cervical Cancer and HPV Research
- Syphilis Diagnosis and Treatment
- Genital Health and Disease
- Urinary Tract Infections Management
- Female Genital Mutilation/Cutting Issues
- Urologic and reproductive health conditions
- Immune Response and Inflammation
- Global Maternal and Child Health
- Adolescent Sexual and Reproductive Health
- Reproductive System and Pregnancy
- Dermatology and Skin Diseases
- Child Nutrition and Water Access
- Gut microbiota and health
- Pneumonia and Respiratory Infections
- Ocular Surface and Contact Lens
- Parasites and Host Interactions
- Urological Disorders and Treatments
- Herpesvirus Infections and Treatments
- Malaria Research and Control
- Mosquito-borne diseases and control
- Ocular Infections and Treatments
- Pediatric health and respiratory diseases
- Pelvic floor disorders treatments
- Insects and Parasite Interactions
London School of Hygiene & Tropical Medicine
2016-2025
Blantyre Institute for Community Ophthalmology
2022-2024
Hospital for Tropical Diseases
1999-2023
Royal London Hospital
2009-2023
University College London
2009-2023
University of London
2009-2022
Northampton General Hospital
2022
University of Illinois Chicago
2010-2021
Direction de la Météorologie Nationale du Niger
2021
Kilimanjaro Christian Medical Centre
2019
We hypothesized that mass distribution of a broad-spectrum antibiotic agent to preschool children would reduce mortality in areas sub-Saharan Africa are currently far from meeting the Sustainable Development Goals United Nations.
We previously reported that laboratory reference strains of Chlamydia trachomatis differing in infection organotropism correlated with inactivating mutations the pathogen's tryptophan synthase (trpBA) genes. Here, we have applied functional genomics to extend this work and find paradigm established for serovars also applies clinical isolates — specifically, all ocular trachoma tested synthase, whereas genital encode a enzyme. Moreover, enzyme activity was directly IFN-γ resistance through an...
Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is an important cause of blindness. Current recommended dosing intervals for mass azithromycin treatment trachoma are based on a mathematical model.We collected conjunctival swabs quantitative polymerase-chain-reaction assay C. trachomatis before and 2, 6, 12, 18, 24 months after in Tanzanian community which was endemic. For ethical reasons, at 18 months, we gave tetracycline eye ointment to residents who had...
Abstract Background Both religious practices and male circumcision (MC) have been associated with HIV other sexually-transmitted infectious diseases. Most studies limited in size not adequately controlled for religion, so these relationships remain unclear. Methods We evaluated between MC prevalence, Muslim Christian 7 diseases using country-specific data among 118 developing countries. used multivariate linear regression to describe associations cervical cancer incidence, prevalence...
Tumor necrosis factor alpha (TNF-alpha) may play a central role in the disease pathogenesis which occurs as consequence of chlamydial infection. To investigate importance TNF-alpha gene promoter polymorphisms and levels tear fluid scarring trachoma, large matched-pair case-control study was performed The Gambia. -308A allele present higher proportion patients (28.4%) than controls (18.4%), with an increasing association for homozygotes (chi2 trend, P = 0.032; frequency, 0.163 0.099 controls;...
Abstract Background Trachoma, caused by Chlamydia trachomatis , remains the worlds leading infectious cause of blindness. Repeated ocular infection during childhood leads to scarring conjunctiva, in-turning eyelashes (trichiasis) and corneal opacity in later life. There is a growing body evidence suggest non-chlamydial bacteria are associated with clinical signs trachoma, independent C. infection. Methods We used deep sequencing V1-V3 region bacterial 16S rRNA gene characterize microbiome...
Current control strategies for soil-transmitted helminths (STH) emphasize morbidity through mass drug administration (MDA) targeting preschool- and school-age children, women of childbearing age adults in certain high-risk occupations such as agricultural laborers or miners. This strategy is effective at reducing those treated but, without massive economic development, it unlikely will interrupt transmission. MDA therefore need to continue indefinitely maintain benefit. Mathematical models...
ABSTRACT Droplet digital PCR (ddPCR) is an emulsion process that performs absolute quantitation of nucleic acids. We developed a ddPCR assay for Chlamydia trachomatis infections and found it to be accurate precise. Using mixtures containing plasmids engineered include the target sequences, we were able quantify with dynamic range between 0.07 3,160 targets/μl ( r 2 = 0.9927) >95% confidence. 1,509 clinical conjunctival swab samples from population in which trachoma endemic Guinea Bissau,...
Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC a unique urinary metabolomic profile compared with benign disease (BN) and healthy (HE) patients. Urine from 43 GC, 40 BN, matched HE patients was analysed using 1H nuclear magnetic resonance (1H-NMR) spectroscopy, generating 77 reproducible metabolites (QC-RSD <25%). Univariate multivariate (MVA) statistics were employed. A parsimonious biomarker of vs investigated LASSO regularised...