A5010592800- Diabetes Treatment and Management
- Transplantation: Methods and Outcomes
- Advanced Causal Inference Techniques
- Cardiac Valve Diseases and Treatments
- Respiratory viral infections research
- Statistical Methods in Clinical Trials
- Metabolism, Diabetes, and Cancer
- Congenital Heart Disease Studies
- Viral Infections and Immunology Research
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Anesthesia and Sedative Agents
- Coronary Artery Anomalies
- Colorectal Cancer Screening and Detection
- Pulmonary Hypertension Research and Treatments
- Colorectal Cancer Surgical Treatments
- Artificial Intelligence in Healthcare
- Organ and Tissue Transplantation Research
- Stoma care and complications
- Statistical Methods and Inference
- Parkinson's Disease Mechanisms and Treatments
- Heart Failure Treatment and Management
- Pharmacology and Obesity Treatment
- Genetic Associations and Epidemiology
Institute for Biomedicine
2022-2023
Eurac Research
2022-2023
University of Padua
2018-2022
University of Lübeck
2022
Public Health Department
2021
Abstract There is increasing evidence for inflammation as a determinant in the pathogenesis of Parkinson’s disease, but its role parkinsonian neurodegeneration remains elusive. It not clear whether inflammatory cascades are causes or consequences dopamine neuron death. In present study, we aim to perform an in-depth statistical investigation causal relationship between and disease using two-sample Mendelian randomization design. Genetic instruments were selected summary-level data from...
Abstract Aims Quantitative echocardiography parameters are seldom used to grade tricuspid regurgitation (TR) severity due relative paucity of validation studies and lack prognostic data. To assess the relationship between TR composite endpoint death hospitalization for congestive heart failure (CHF); identify threshold values vena contracta width (VCavg), effective regurgitant orifice area (EROA), volume (RegVol), fraction (RegFr) define low, intermediate, high-risk based on patients’...
The present study aims to compare the performance of eight Machine Learning Techniques (MLTs) in prediction hospitalization among patients with heart failure, using data from Gestione Integrata dello Scompenso Cardiaco (GISC) study. GISC project is an ongoing that takes place region Puglia, Southern Italy. Patients a diagnosis failure are enrolled long-term assistance program includes adoption online platform for sharing between general practitioners and cardiologists working hospitals...
In randomized controlled trials (RCTs), sodium-glucose co-transporter-2 (SGLT2) inhibitors have been shown to confer glycaemic and extra-glycaemic benefits. The DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes) study was a multicentre retrospective designed evaluate the baseline characteristics of patients receiving dapagliflozin vs those selected comparators (dipeptidyl peptidase-4 inhibitors, gliclazide, or glucagon-like peptide-1 receptor agonists), drug effectiveness...
In recent years, there has been a widespread cross-fertilization between Medical Statistics and Machine Learning (ML) techniques.
Hospital-acquired infections with Klebsiella spp. and emerging multidrug-resistant strains are a persistent concern. Identifying high-risk groups is crucial for the evaluation of preventive interventions like vaccines. We determined incidence developed prediction models postsurgical in adult elective surgery patients. This multicentre retrospective case-control study, seven European hospitals, included patients ≥50 years old who underwent between 2012 2021. Using multivariable logistic...
Primary breast cancer (PBC) is a heterogeneous disease at the clinical, histopathological, and molecular levels. The improved classification of PBC might be important to identify subgroups disease, relevant patient management. Machine learning algorithms may allow better understanding relationships within clinical syndromes. This work aims show potential unsupervised techniques for improving in PBC. A dataset 712 women with used as motivating example. set variables containing biological...
According to cardiovascular outcome trials, some sodium-glucose contransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) are recommended for secondary prevention in type 2 diabetes (T2D). In this real-world study, we compared the simultaneous reductions HbA1c, body weight systolic blood pressure after initiation of dapagliflozin or GLP-1RA as second a more advanced line therapy.DARWIN-T2D was retrospective multi-centre study conducted at specialist clinics...
Adults with congenital heart disease (ACHD) represent a growing population. To evaluate frequency, type and outcomes of cardiac surgery in ACHD, we gathered data from the European Congenital Heart Surgeons Association Database 20,602 adult patients (≥18 years) diagnosis who underwent surgery, between January 1997 December 2017. We demonstrated that overall surgical workload (as absolute frequencies procedures per year) for this specific subset increased steadily during study period. The most...
Several epidemiological studies found an association between acute exposure to fine particulate matter of less than 2.5 μm and 10 in aerodynamic diameter (PM2.5 PM10) cardiovascular diseases, ventricular fibrillation incidence mortality. The effects pollution on atrial (AF) beyond the first several hours remain controversial. A total 145 patients with implantable cardioverter-defibrillators (ICDs), cardiac resynchronization therapy defibrillators (ICD-CRT), or pacemakers were enrolled this...
Metabolites are intermediates or end products of biochemical processes involved in both health and disease. Here, we take advantage the well-characterized Cooperative Health Research South Tyrol (CHRIS) study to perform an exome-wide association (ExWAS) on absolute concentrations 175 metabolites 3294 individuals. To increase power, imputed identified variants into additional 2211 genotyped individuals CHRIS. In resulting dataset 5505 individuals, 85 single-variant genetic associations, which...
DPP-4 inhibitors (DPP4i) and sulfonylureas are popular second-line therapies for type 2 diabetes (T2D), but there is a paucity of real-world studies comparing their effectiveness in routine clinical practice. This was multicenter retrospective study on outpatient clinics the DPP4i versus gliclazide extended release. The primary endpoint change from baseline HbA1c. Secondary endpoints were changes fasting plasma glucose, body weight, systolic blood pressure. Automated software extracted data...
(1) Background: The high heterogeneity of inflammatory bowel disease (IBD) makes the study this condition challenging. In subjects affected by Crohn's (CD), extra-intestinal manifestations (EIMs) have a remarkable potential impact on health status. Increasing numbers patient characteristics and small size analyzed samples make EIMs prediction very difficult. Under such constraints, Bayesian machine learning techniques (BMLTs) been proposed as robust alternative to classical models for...
Background and Objective: Participation in organised out-of-school leisure-time activities (OLTAs) has been shown to have a positive impact on community health practices lessen inequities social environmental opportunities among youths. According the capital theory, OLTAs foster bridging ties that allow individuals forge new, wider-ranging connections, increasing integration for identity-related exploration. This study aimed describe participation different types of its association with...
Delirium is a psycho-organic syndrome common in hospitalized patients, especially the elderly, and associated with poor clinical outcomes. This study aims to identify predictors that are mostly risk of delirium episodes using machine learning technique (MLT). A random forest (RF) algorithm was used evaluate association between subject’s characteristics 4AT (the 4 A’s test) score screening tool for delirium. RF implemented information based on demographic characteristics, comorbidities, drugs...
Introduction We sought to determine the surgical outcomes of patients with anomalous origin left coronary artery from pulmonary (ALCAPA) enrolled in European Congenital Heart Surgeons Association (ECHSA) database. Materials and Methods From 1999 2019, 907 ALCAPA underwent repair were included current study. The primary outcome was in-hospital mortality. Secondary frequency results concomitant mitral valve surgery postoperative mechanical circulatory support (MCS). Results overall mortality...
To evaluate the ability of Weighted-Incidence Syndromic Combination Antibiograms (WISCA) to inform selection empirical antibiotic regimens for suspected paediatric community-acquired urinary tract infections.
Abstract Background Despite improvement in lung function, most transplant (LTx) recipients show an unexpectedly reduced exercise capacity that could be explained by persisting peripheral muscle dysfunction of multifactorial origin. We analyzed the course symptoms, including dyspnea, effort and pain its relation with cardiac pulmonary function parameters during incremental testing. Methods Twenty-four bilateral LTx were evaluated observational cross-sectional study. Recruited patients...
(1) Background: Propensity score methods gained popularity in non-interventional clinical studies. As it may often occur observational datasets, some values baseline covariates are missing for patients. The present study aims to compare the performances of popular statistical deal with data propensity analysis. (2) Methods: Methods that account during estimation process and based on imputation values, such as multiple imputations, were considered. applied dataset an ongoing prospective...
This paper presents the epidemiology of foreign body injuries in Pediatric Emergency Department (PED) Padova (Italy) along with its trends over an eleven-year period based on administrative data. Annual incidence rates (IRs) PED presentations for (FB) per 1000 person-years were calculated. Univariable and multivariable generalized linear (GLM) Poisson models estimated to evaluate relationship between FB injury year, triage priority, nationality, site, type. During study period, there 217,900...
Abstract Air pollution has been linked to an increased risk of several respiratory diseases in children, especially tract infections. The present study aims evaluate the association between pediatric emergency department (PED) presentations for bronchiolitis and air pollution. PED due children aged less than 1 year were retrospectively collected from 2007 2018 Padova, Italy, together with daily environmental data. A conditional logistic regression based on a time‐stratified case‐crossover...