A5017623548- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Endoplasmic Reticulum Stress and Disease
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Corneal surgery and disorders
- Cancer-related Molecular Pathways
- Family and Patient Care in Intensive Care Units
- Autoimmune and Inflammatory Disorders Research
- Retinal and Macular Surgery
- Autophagy in Disease and Therapy
- Ophthalmology and Visual Health Research
- Ocular Diseases and Behçet’s Syndrome
- Microbial Inactivation Methods
- Mechanisms of cancer metastasis
- Healthcare Operations and Scheduling Optimization
- Biomedical Research and Pathophysiology
- Ocular Oncology and Treatments
- Blood Pressure and Hypertension Studies
- Melanoma and MAPK Pathways
- Inflammasome and immune disorders
- Cancer Mechanisms and Therapy
Columbia University
2022-2024
NYU Langone Health
2022-2024
New York University
2022-2024
Penn Presbyterian Medical Center
2017-2023
University of Pennsylvania
2016-2023
Vitreous Retina Macula Consultants of New York
2022-2023
Kaiser Permanente Vallejo Medical Center
2021
Kaiser Permanente Oakland Medical Center
2020
Kaiser Foundation Hospital
2018
Kaiser Foundation Hospital
2018
In Drosophila melanogaster , accessory gland proteins (Acps) that a male transfers during mating affect his reproductive success by altering the female's behaviour and physiology. To test role of condition in expression Acps, we manipulated pre-adult environment examined adult males for relative transcript abundance nine post-copulatory traits Acps influence. Larval culture density had no effect on any measured trait. nutrient availability impacted number sperm transferred stored, male's...
Visit adherence has been shown to play a significant role in patient health outcomes. The effect of missing visits on visual acuity (VA) individuals with neovascular age-related macular degeneration yet be characterized.To quantify the association between patients' randomized clinical trial and VA based 4 visit metrics.This is secondary analysis Comparison Age-Related Macular Degeneration Treatment Trial trial. Individuals were recruited from 44 centers United States February 2008 December...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
To report 2 cases with a novel finding of bullous epithelial keratopathy associated netarsudil use.A 72-year-old man history primary open angle glaucoma was started on daily in both eyes for uncontrolled intraocular pressures despite treatment latanoprost, brimonidine, and dorzolamide-timolol. One month later he presented bilateral conjunctival hyperemia, predominantly inferior corneal bullae, keratic precipitates without hypopyon. Netarsudil discontinued, the patient topical steroids. week...
CASE A 10-year-old girl presented with fever for 15 days, cough and rapid breathing 12 days abdominal pain 6 days. The was high grade (peaking at 40 °C), accompanied by chills rigors, occurring twice or thrice each day. Three after the onset of fever, she developed a dry and, soon thereafter, breathlessness. She diagnosed pneumonia local hospital received oxygen therapy, intravenous antibiotics supportive care. About week illness, complained intermittent, diffuse unrelated to meals not...
Purpose: To characterize macular blood flow connectivity in vivo using high-resolution optical coherence tomography (HighRes OCT). Methods: Cross-sectional, observational study. Dense (6-µm interscan distance) perifoveal HighRes OCT raster scans were performed on healthy participants. mitigate the limitations of projection-resolved OCT-angiography, and structural data used to observe vascular structures superficial complex (SVC) deep complex. Vascular segmentation rendering Imaris 9.5...
Replacement of autogenous or allograft bones by artificial graft materials represents a growing area interest in current bone repair strategies. Bioactive ceramics particulate form, such as Bioglass (BG) 45S5, stimulate mineralization comparable to autologous grafts, but have potential issues particle migration and inflammation. The aim this study was employ chondroitin sulfate- (CS-) based bioadhesive improve integration the bioglass (NovaBone Putty) prevent promote regeneration. This BG-CS...
We investigate the function of V83I polymorphism (m.6150G>A, rs879053914) in mitochondrial cytochrome c oxidase subunit 1 (MT-CO1) gene and its role African American (AA) primary open-angle glaucoma (POAG).
GRP94 is a major glycoprotein in the endoplasmic reticulum with calcium-binding properties. Recently, has been shown to bind unassembled forms of multimeric proteins and peptides. We report here that stable association mutated form herpes simplex type virus 1 (HSV-1) B, but not fully processed viral protein. Both glycosylated unglycosylated are capable complexing mutated, conformation-defective glycoprotein. Cotransfection expression vectors for gB grp94 promoter fusion genes revealed...
Journal Article A two-time-scale model for hospital patient flow Get access M. Ramakrishnan, Ramakrishnan **Email: m.ramakrishnan@ms.unimelb.edu.au Search other works by this author on: Oxford Academic Google Scholar D. Sier, Sier P. G. Taylor IMA of Management Mathematics, Volume 16, Issue 3, July 2005, Pages 197–215, https://doi.org/10.1093/imaman/dpi014 Published: 01 2005
Purpose: Advancements in retinal imaging have augmented our understanding of the pathology and structure–function relationships disease. No single diagnostic test is sufficient; rather, management strategies increasingly involve synthesis multiple modalities. Methods: This literature review editorial offer practical clinical guidelines for how retina specialist can use multimodal to manage conditions. Results: Various modalities information on different aspects structure function. For...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
The t(14,18) chromosomal translocation that occurs in human follicular lymphoma constitutively activates the BCL2 gene and disrupts control of apoptosis.Interestingly, 70% translocations are confined to three 15-bp clusters positioned within a 150-bp region (major breakpoint or [MBR]) untranslated portion terminal exon 3. We analyzed DNA-protein interactions MBR, as these may play some role targeting this region.An 87-bp segment (87MBR) immediately 3 cluster was essential for interaction...
We report a case of meningitis due to Salmonella typhimurium in four-month-old female infant. The child was brought the pediatric emergency department with complaints fever, cold, and generalized convulsion. On examination, febrile having seizures. anterior fontanelle not bulging. Lumbar puncture done isolated from cerebrospinal fluid. Initially infant improved clinically appropriate management, but had fatal outcome nosocomial pneumonia.
The 94-kDa glucose-regulated protein (GRP94) is a glycoprotein in the endoplasmic reticulum (ER). It has been characterized as Ca2+-binding and molecular chaperone. In this report we show that highly purified GRP94 exhibits an active Mg2+-dependent serine kinase activity (termed 94-kinase). 94-kinase can be recovered from ER membrane fractions able to phosphorylate both constitutive stress-induced forms of GRP94, correlating with their induction kinetics. distinct casein II. contrast...
The purpose of this study is to evaluate the role mitochondrial inheritance plays in primary open-angle glaucoma (POAG) characteristics African Americans.
Abstract During the past 15 years, new treatment paradigms for neovascular age-related macular degeneration (nvAMD) have evolved due to advent of intravitreal anti-vascular endothelial growth factor (VEGF) therapy and rapid advances in retinal imaging. Recent publications describe eyes with type 1 neovascularization (MNV) as showing more resistance atrophy than other lesion types. We sought explore whether perfusion status native choriocapillaris (CC) surrounding MNV influences its pattern...
To present a case of glioblastoma multiforme which initially presented with only ophthalmic manifestations.A 48-year-old man decreased vision and pain eye movements the right eye. MRI brain showed increased T2/FLAIR signal involving optic nerve no other identified abnormalities. He was treated intravenous steroids for presumed neuritis. His visual acuity then rapidly worsened to light perception, new orbital apex symptoms including central retinal artery vein occlusions inferior division...
No method of grading visual field (VF) defects has been widely accepted throughout the glaucoma community. The SCHEIE (Systematic Classification Humphrey fields-Easy Interpretation and Evaluation) system for glaucomatous fields was created to convey qualitative quantitative information regarding in an objective, reproducible, easily applicable manner research purposes.