A5007468667- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Osteoarthritis Treatment and Mechanisms
- Sports injuries and prevention
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Knee injuries and reconstruction techniques
- Lower Extremity Biomechanics and Pathologies
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Advanced Proteomics Techniques and Applications
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Muscle Physiology and Disorders
- Bone and Joint Diseases
- Medicinal plant effects and applications
- Advancements in Battery Materials
- Gut microbiota and health
- Nerve Injury and Rehabilitation
- Genetic Associations and Epidemiology
- Hippo pathway signaling and YAP/TAZ
- Machine Learning in Bioinformatics
Sichuan University
2023-2025
West China Hospital of Sichuan University
2023-2025
Nanchang Hangkong University
2025
Kettering University
2023-2024
Memorial Sloan Kettering Cancer Center
2020-2024
Guangdong Academy of Sciences
2024
Affiliated Hospital of Southwest Medical University
2023
Southwest Medical University
2023
Equal opportunity tissue regeneration Tissue is thought to be driven primarily by rare stem cells with distinctive properties. Single-cell RNA sequencing allows rigorous testing of this hypothesis. Karthaus et al. examined the normal prostate in mice after androgen ablation, a common treatment for cancer (see Perspective Kelly). Unexpectedly, they found that addition cells, large population differentiated was major contributor regeneration, result confirmed study human tissue. Investigation...
Drug resistance in cancer is often linked to changes tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated causes of lineage prostate its relationship antiandrogen resistance. We found that initiates an epithelial population defined by mixed luminal-basal phenotype it depends on increased Janus kinase (JAK) fibroblast growth factor receptor (FGFR) activity. Organoid...
Knee osteoarthritis is a common degenerative joint disease involving multiple pathological processes, including energy metabolism, cartilage repair, and osteogenesis. To investigate the alterations in critical metabolic pathways differential proteins patients through metabolomic proteomic analyses to explore potential mechanisms underlying synovial osteogenesis during progression. Metabolomics was used analyze metabolites fluid synovium of (osteoarthritis group: 10; control 10), whereas...
Abstract While regulatory T (T reg ) cells are traditionally viewed as professional suppressors of antigen presenting and effector in both autoimmunity cancer, recent findings distinct cell functions tissue maintenance suggest that their purview extends to a wider range is broader than previously assumed. To elucidate tumoral ‘connectivity’ diverse tumor-supporting accessory types, we explored immediate early changes single-cell transcriptomes upon punctual depletion experimental lung cancer...
Targeting cell surface molecules using radioligand and antibody-based therapies has yielded considerable success across cancers. However, it remains unclear how the expression of putative lineage markers, particularly molecules, varies in process plasticity, wherein tumor cells alter their identity acquire new oncogenic properties. A notable example plasticity is transformation prostate adenocarcinoma (PRAD) to neuroendocrine cancer (NEPC)—a growing resistance mechanism that results loss...
Dynamic covalent boronic ester polymer networks have received extensive attention as self-healing materials, and they can be applied in all-solid electrolytes. Herein, some classes of solid-state electrolytes with ability were developed by incorporating dynamic structure into a comb-like polyethylene glycol network. Due to the transesterification reactions bonds, borate ester-containing cross-linked electrolyte free hydroxyl (3OHPBASPE-2) exhibits dynamically alter its network topology,...
<p>Sports injuries are one of the most common diseases, and repair regeneration joint soft tissues (ligaments, tendons, cartilage, etc.) involved in them challenging. Traditional treatment strategies, such as drugs, physical therapy, surgery, difficult to achieve tissue reconstruction natural physiological functions. Regenerative medicine offers promising solutions, including biotherapy, engineering, prosthesis or organ transplantation. These approaches aim regenerate damaged tissues,...
Osteoarthritis (OA) is a prevalent chronic degenerative joint disease worldwide. Obesity has been linked to OA, and increased free fatty acid levels (e.g., palmitate) contribute inflammatory responses cartilage degradation. Xanthohumol (Xn), bioactive prenylated chalcone, was shown exhibit antioxidative, anti-inflammatory, anti-obesity capacities in multiple diseases. However, clear description of the preventive effects Xn on obesity-associated OA unavailable. This study aimed assess...
Background: Osteoarthritis (OA) is a common disease that causes joint pain and disability. Stem cell therapy emerging as promising treatment for OA. Purpose: To evaluate the ability of peripheral blood–derived mesenchymal stem cells (PBMSCs) combined with donor-matched platelet-rich plasma (PRP) to treat OA in rabbit model. Study Design: Controlled laboratory study. Methods: PBMSCs PRP were isolated prepared from same rabbit. treated serum-free medium, fetal bovine serum, PRP; series PBMSC...
Targeting cell surface molecules using radioligand and antibody-based therapies has yielded considerable success across cancers. However, it remains unclear how the expression of putative lineage markers, particularly molecules, varies in process plasticity, wherein tumor cells alter their identity acquire new oncogenic properties. A notable example plasticity is transformation prostate adenocarcinoma (PRAD) to neuroendocrine cancer (NEPC)--a growing resistance mechanism that results loss...
Background: Osteoarthritis (OA) is a prevalent and disabling disease that affects significant proportion of the global population. Urine-derived stem cells (USCs) have shown great prospects in treatment OA, but there no study has compared them with traditional cells. Purpose: This aimed to compare therapeutic efficacy mechanisms USCs adipose-derived (ADSCs) for OA treatment. Study Design: Controlled laboratory study. Methods: We biological properties ADSCs using CCK-8, colony formation, EdU,...
Summary Oncogenic alterations to DNA are not transforming in all cellular contexts 1, 2 . This may be due pre-existing transcriptional programs the cell of origin. Here, we define anatomic position as a major determinant why cells respond specific oncogenes. Cutaneous melanoma arises throughout body, whereas acral subtype on palms hands, soles feet, or under nails 3 We sequenced cutaneous and melanomas from large cohort human patients found enrichment for BRAF mutations but CRKL...
Abstract Lineage plasticity is a well–established mechanism of resistance to targeted therapies in lung and prostate cancer, where tumors transition from adenocarcinoma small–cell or neuroendocrine carcinoma. Through single–cell analysis cohort heavily–treated castration–resistant human cancers (CRPC), we report greater degree than previously appreciated, with multiple distinct (NEPC), mesenchymal (EMT–like), other subpopulations detected within single biopsies. To explore the steps leading...
8042 Background: Tumor plasticity, especially histological transformation, is an emergent mechanism of therapeutic resistance. Lung adenocarcinoma (LUAD) can transform to small cell lung cancer (SCLC), a more aggressive tumor type neuroendocrine (NE) histology, leading EGFR inhibitor resistance and disease phenotype. TP53 RB1 loss are enriched but insufficient for NE it remains unknown what additional molecular changes underlie plasticity. We use single-cell RNA sequencing (scRNA-seq)...
Abstract Inflammation is linked to prostate cancer progression. Inflammatory cell infiltrates are commonly observed in biopsies, and inflammation-induced lesions (proliferative inflammatory atrophy, PIA) precursors of cancer. However, the mechanism by which inflammation impacts progression poorly understood. Here, we investigated significance on using a cMyc-driven adenocarcinoma mouse model (Hi-Myc). We robust tumor-associated macrophage (TAM) infiltrate early during Hi-Myc tumors....
Abstract The inherent plasticity of tumor cells provides a mechanism resistance to many molecularly targeted therapies, exemplified by adeno-to-neuroendocrine lineage transitions seen in prostate and lung cancer. Here we investigate the root cause this primary murine organoid model that mirrors transition patients. These lose luminal identity within weeks following deletion Trp53 Rb1 , ultimately acquiring an Ar-negative, Syp+ phenotype after orthotopic vivo transplantation. Single-cell...
Abstract Objective The causal relationship between gut microbiota and sarcopenia remains unclear. objective is to investigate the association related traits, including low hand grip strength (LHGS), appendicular lean mass (ALM), usual walking speed (UWP), using two-sample Mendelian randomization (MR). Design Two sample study. Setting Participants Genetic instruments predicting were from an existing genome-wide study (GWAS) in 18,340 individuals (85% European descent). Summary data for LHGS...