A5087169592- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- X-ray Diffraction in Crystallography
- Viral Infections and Vectors
- Crystallization and Solubility Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Virology and Viral Diseases
- Malaria Research and Control
- Monoclonal and Polyclonal Antibodies Research
- Receptor Mechanisms and Signaling
- Polyomavirus and related diseases
- HIV Research and Treatment
- Gut microbiota and health
- Adenosine and Purinergic Signaling
- HIV-related health complications and treatments
- CAR-T cell therapy research
- Immune Response and Inflammation
- Insect symbiosis and bacterial influences
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Nitric Oxide and Endothelin Effects
Cornell University
2020-2025
Weill Cornell Medicine
2024
Johnson & Johnson (Israel)
2024
Janssen (Belgium)
2022
Icahn School of Medicine at Mount Sinai
2017-2021
Providence College
2021
Mount Sinai Health System
2020
Hartford Public Library
2019
Momenta Pharmaceuticals (United States)
2016-2019
Hartford Financial Services (United States)
2019
Abstract Thymectomy in mice on neonatal day 3 leads to the development of multiorgan autoimmune disease due loss a CD+CD25+ T cell regulatory population their peripheral lymphoid tissues. Here, we report identification CD4+ cells circulation humans expressing high levels CD25 that exhibit vitro characteristics identical with those CD4+CD25+ isolated mice. With TCR cross-linking, CD4+CD25high did not proliferate but instead totally inhibited proliferation and cytokine secretion by activated...
Programmed death-1 ligand (PD-L)1 and PD-L2 are ligands for programmed (PD-1), a member of the CD28/CTLA4 family expressed on activated lymphoid cells. PD-1 contains an immunoreceptor tyrosine-based inhibitory motif mice deficient in develop autoimmune disorders suggesting defect peripheral tolerance. Human PD-L1 immature dendritic cells (iDC) mature (mDC), IFN-gamma-treated monocytes, follicular Using mAbs, we show that blockade results enhanced T cell proliferation cytokine production,...
One antibody for all and antibodies one Antibodies against related flavi-viruses such as dengue (DENV) West Nile (WNV) can cross-react with Zika virus (ZIKV) could thereby increase disease severity. Bardina et al. tested whether DENV WNV from humans, or even yellow fever vaccination, enhance ZIKV infection. In a mouse model, low titers of enhanced viremia, especially in the spinal cord testes, whereas high remained protective. Generally, were less disease-enhancing than antibodies, and,...
The inhibitory receptor PD-1 blocks T cell proliferation by preventing cells from leaving the G 1 phase of cycle.
Programmed death-1 (PD-1), a member of the CD28 costimulatory receptor family, is expressed by germinal center-associated T cells in reactive lymphoid tissue. In study wide range lymphoproliferative disorders, neoplastic 23 cases angioimmunoblastic lymphoma were immunoreactive for PD-1, but other subtypes cell and B non-Hodgkin lymphoma, as well classic Hodgkin did not express PD-1. The pattern PD-1 immunostaining was similar to that reported CD10, recently described marker lymphoma....
Zika virus (ZIKV) is a mosquito borne flavivirus, which was neglected tropical pathogen until it emerged and spread across the Pacific Area Americas, causing large human outbreaks associated with fetal abnormalities neurological disease in adults. The factors that contributed to emergence, change pathogenesis of ZIKV are not understood. We previously reported evades cellular antiviral responses by targeting STAT2 for degradation cells. In this study, we demonstrate Stat2-/- mice highly...
The gut microbiota promotes immune system development in early life, but the interactions between metabolome and cells neonatal remain largely undefined. Here, we demonstrate that is uniquely enriched with neurotransmitters, including serotonin, specific bacteria directly produce serotonin while down-regulating monoamine oxidase A to limit breakdown. We found signals T increase intracellular indole-3-acetaldehdye inhibit mTOR activation, thereby promoting differentiation of regulatory cells,...
Abstract Zika virus is a mosquito-borne flavivirus closely related to dengue that can cause severe disease in humans, including microcephaly newborns and Guillain-Barré syndrome adults. Specific treatments vaccines for are not currently available. Here, we isolate characterize four monoclonal antibodies (mAbs) from an infected patient target the non-structural protein NS1. We show while these non-neutralizing, NS1-specific mAbs engage FcγR without inducing antibody dependent enhancement...
Early reports indicated that ECV304 was a spontaneously-transformed line derived from Japanese human umbilical vein endothelial cells (HUVEC) culture. Many morphological, immunochemical, and genetic studies provided further evidence valuable biomedical research tool could be used to study processes include angiogenesis in vitro signal transduction by variety of G protein-coupled receptors. However, several distinct differences between HUVEC are now apparent recent have similarity T24/83,...
Selective isolation of only those CD4+ T cells that display the highest levels CD25 by FACS results in a highly homogeneous regulatory population as defined functional activity and expression multiple surface antigens. Thus greater than 98% CD4+CD25high express CD45RO absence CD45RA expression. Upon TCR stimulation are both anergic tolerogenic they inhibit proliferation cytokine secretion activated CD4+CD25- responder contact-dependent manner. In contrast, lower more heterogeneous their...
An engineered trivalent Fc drug candidate is a potent inhibitor of FcγR-driven immune cell activation and autoimmune diseases in animal models.
ABSTRACT Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis arthralgia over the past decade. These include recent outbreak in Caribbean islands Americas that caused more than 1 million cases viral arthralgia. Despite major impact CHIKV on global health, determinants promote CHIKV-induced disease are incompletely understood. Most strains contain conserved opal stop codon at end nsP3 gene. However,...
The ability to protect vulnerable populations such as pregnant women and children from Zika virus other arbovirus infections is essential preventing the devastating complications induced by these viruses. One class of antiviral therapies may lie in known pregnancy-acceptable drugs that have potential mitigate disease, yet this has not been explored detail. In study, we show common antiparasitic drug atovaquone inhibits replication through intracellular nucleotide depletion can impair ZIKV...
HIV-1 causes a persistent infection of the immune system that is associated with chronic comorbidities. The mechanisms underlie this inflammation are poorly understood. Emerging literature has implicated proinflammatory purinergic receptors and downstream signaling mediators in infection. This study probed whether inhibitors would reduce HIV-1-stimulated inflammation. An
Graft-versus-host disease (GVHD) remains a frequent and severe complication of allogeneic stem cell transplantation (SCT). One approach to reducing alloreactivity is deplete the graft alloreactive T cells. Global depletion results in poor immune reconstitution with high mortality from viral infections relapse. Therefore, an selectively cells without compromising other responses would be highly beneficial. We undertook studies identify inducible activation marker expressed on effector...