A5020163203- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Monoclonal and Polyclonal Antibodies Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- Click Chemistry and Applications
- Advanced Biosensing Techniques and Applications
- Bacteriophages and microbial interactions
- Laser-Ablation Synthesis of Nanoparticles
- Biometric Identification and Security
- Theoretical and Computational Physics
- Biosensors and Analytical Detection
- Material Dynamics and Properties
- Polymer Surface Interaction Studies
- Bacterial Genetics and Biotechnology
- Magnetism in coordination complexes
- Alzheimer's disease research and treatments
- Nanofabrication and Lithography Techniques
- Molecular Junctions and Nanostructures
- Graphene and Nanomaterials Applications
- Pharmacological Effects and Toxicity Studies
- Antimicrobial Peptides and Activities
- Organic Chemistry Cycloaddition Reactions
RMIT University
2014-2025
MIT University
2020-2025
The dynamic nature of bacterial lipid diversity and membrane properties in response to stress conditions is discussed. This emerging area has implications for a range cellular processes drug design selective cell targeting.
Abstract Label-free surface-enhanced Raman spectroscopy (SERS) can interrogate systems by directly fingerprinting their components’ unique physicochemical properties. In complex biological however, this yield highly overlapping spectra that hinder sample identification. Here, we present an artificial-nose inspired SERS approach where spectral data is obtained as a function of sensor surface chemical functionality. Supported molecular dynamics modeling, show mildly selective self-assembled...
Quantum-sized metallic clusters protected by biological ligands represent a new class of luminescent materials; yet the understanding structural information and photoluminescence origin these ultrasmall remains challenge. Herein we systematically study surface ligand dynamics ligand-metal core interactions peptide-protected gold nanoclusters (AuNCs) with combined experimental characterizations theoretical molecular simulations. We show that peptide sequence plays an important role in...
The motion of the confined doxorubicin drug molecule exhibits an interesting combination anomalous diffusion features.
The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody–antigen recognition, is a key challenge in developing targeted nanomedicines. Herein, we report the targeting ability metal–phenolic network (MPN)-coated gold nanoparticles with surface-physisorbed against respective antigens. MPN coatings were self-assembled from metal ions (FeIII, CoII, CuII, NiII, or ZnII) cross-linked tannic acid. Upon physisorption antibodies, all particle systems exhibited...
Ultrasmall peptide-protected gold nanoclusters are a promising class of bioresponsive material exhibiting pH-sensitive photoluminescence. We present theoretical insight into the effect peptide-ligand environment has on pH-responsive fluorescence, with aim enhancing rational design for bioapplications. Employing hybrid quantum/classical computational methodology, we systematically calculate deprotonation free energies N-terminal cysteine amine groups in proximity to inherently fluorescent...
Abstract Staphylococcus aureus is a leading cause of nosocomial implant-associated infections, causing significant morbidity and mortality, underscoring the need for rapid, non-invasive, cost-effective diagnostics. Here, we optimise synthesis renal-clearable gold nanoclusters (AuNCs) enhanced catalytic activity with aim developing sensitive colourimetric diagnostic bacterial infection. All-atom molecular dynamics (MD) simulations confirm stability glutathione-coated AuNCs surface access...
Immunoreagents, most commonly antibodies, are integral components of lateral flow immunoassays. However, the use antibodies comes with limitations, particularly relating to their reproducible production, and poor thermal chemical stability. Here, we employ phage display develop affibodies, a class nonimmunoglobulin affinity proteins based on small three-helix bundle scaffold, against SARS-CoV-2 Spike protein. Subsequently, demonstrate utility viability affibodies directly replace in In...
A single-step gold nanoparticle (AuNP)-based immunoassay is demonstrated in which the surface tagged with short viral peptide epitopes. Antiviral antibodies monoclonal specificity trigger aggregation yielding a colorimetric response that enables detection of low-nanomolar range within few minutes. In silico insights into interactions at epitope–gold interface demonstrate conformational landscape exhibited by epitopes strongly influenced amino acid sequence and location particular residues...
Abstract Due to the variety of roles served by cell membrane, its composition and structure are complex, making it difficult study. Bioorthogonal reactions, such as strain promoted azide‐alkyne cycloaddition (SPAAC), powerful tools for exploring function biomolecules in their native environment but have been largely unexplored within context lipid bilayers. Here, we developed a new approach study SPAAC reaction liposomal membranes using azide‐ strained alkyne‐functionalized Förster resonance...
Metal-phenolic networks (MPNs) are amorphous materials that can be used to engineer functional films and particles. A fundamental understanding of the heat-driven structural reorganization MPNs offer opportunities rationally tune their properties (e.g., size, permeability, wettability, hydrophobicity) for applications such as drug delivery, sensing, tissue engineering. Herein, we use a combination single-molecule localization microscopy, theoretical electronic structure calculations,...
Ionic charge transport is a ubiquitous language of communication in biological systems. As such, bioengineering constant need innovative, soft, and biocompatible materials that facilitate ionic conduction. Low molecular weight gelators (LMWGs) are complex self-assembled have received increasing attention recent years. Beyond their biocompatible, self-healing, stimuli responsive facets, LMWGs can be viewed as "solid" electrolyte solution. In this work, we investigate...
Human amylin is an inherently disordered protein whose ability to form amyloid fibrils linked the onset of type II diabetes. Graphitic nanomaterials have potential in managing diseases as they can disrupt aggregation processes biological settings, but optimising these materials prevent fibrillation challenging. Here, we employ bias-exchange molecular dynamics simulations systematically study structure and adsorption preferences on graphitic nanoflakes that vary their physical dimensions...
Nucleic acids play key roles in Nature, including storage of genetic information and translation into a wide variety proteins that collectively build up cells. Their intrinsic programmability can be utilized to bind specific targets for biomedical applications. However, naturally derived nucleic are susceptible degradation their large-scale synthesis is costly. Although artificial polymeric show great promise, they typically more flexible, therefore secondary structure hard control. Here, we...
Computational modeling is a virtual microscope providing molecular insight into the complex interactions occurring at nano-bio interfaces. The image shows atomistic landscape of peptide-adlayer on gold nanoparticles, physicochemical information needed to tailor design efficient colorimetric biosensors. successes and challenges theoretical simulations in facilitating nanomaterial for biomedicine are reviewed page 2395 by I. Yarovsky co-workers.
Due to the variety of roles served by cell membrane, its composition and structure are complex, making it difficult study. Bioorthogonal reactions, such as strain promoted azide–alkyne cycloaddition (SPAAC), powerful tools for exploring function biomolecules in their native environment but have been largely unexplored within context lipid bilayers. Here, we developed a new approach study SPAAC reaction liposomal membranes using azide- strained alkyne-functionalized Förster resonance energy...
Abstract Due to the variety of roles served by cell membrane, its composition and structure are complex, making it difficult study. Bioorthogonal reactions, such as strain promoted azide‐alkyne cycloaddition (SPAAC), powerful tools for exploring function biomolecules in their native environment but have been largely unexplored within context lipid bilayers. Here, we developed a new approach study SPAAC reaction liposomal membranes using azide‐ strained alkyne‐functionalized Förster resonance...
Edition is aj ournalo ft he Gesellschaft Deutscher Chemiker (GDCh), the largest chemistryrelated scientific society in continental Europe.Information on various activities and services of GDCh, for example, cheaper subscription to Angewandte Chemie International Edition,aswell as applications membership can be found at www.gdch.deor requested from Postfach 900440, D-60444 Frankfurt am Main, Germany.…determines product selectivity oxidative coupling CH 4 shown cover.In their Communication...