A5103129999- Fermentation and Sensory Analysis
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Yeasts and Rust Fungi Studies
- Probiotics and Fermented Foods
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Horticultural and Viticultural Research
- Microbial Metabolism and Applications
- Retinoids in leukemia and cellular processes
- Fungal and yeast genetics research
- MicroRNA in disease regulation
- Microbial Community Ecology and Physiology
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Medicinal Plant Research
- Plant Ecology and Soil Science
- Ecology and Vegetation Dynamics Studies
- Photodynamic Therapy Research Studies
- Tea Polyphenols and Effects
- Plant Pathogens and Fungal Diseases
- Meningioma and schwannoma management
- interferon and immune responses
- Plant and animal studies
- Cancer Cells and Metastasis
First Affiliated Hospital of Harbin Medical University
2013-2025
Harbin Medical University
2011-2025
Institute of Microbiology
2019-2025
Chinese Academy of Sciences
2020-2025
State Key Laboratory of Mycology
2023
University of Chinese Academy of Sciences
2019-2021
Heilongjiang University
2020-2021
Yili Normal University
2021
Takarazuka University of Medical and Health Care
2015
Northeast Normal University
2014
Light-flavor Baijiu fermentation is a typical spontaneous solid-state process fueled by variety of microorganisms. Mechanized processes have been increasingly employed in production to replace traditional manual operation processes, however, the microbiological and physicochemical dynamics mechanized remain largely unknown. Here, we investigated microbial community succession flavor compound formation during whole light-flavor using conventional dilution plating method, PacBio...
Daqu is a traditional starter for Baijiu fermentation and produced by spontaneous of ground moistened barley or wheat. The quality traditionally evaluated based on physicochemical subjective sensory parameters without microbiological analysis. Here, we compared the characteristics qualified (QD) inferior (ID) Daqu, their microbial communities plate counting PacBio SMRT sequencing rRNA gene libraries, impacts fermentation. results showed that glucoamylase α-amylase activities QD were...
Recent studies have revealed that miR-196a is upregulated in glioblastoma multiforme (GBM) and it correlates with the clinical outcome of patients GBM. However, its potential regulatory mechanisms GBM never been reported. We used quantitative real-time PCR to assess expression levels 132 specimens a single institution. Oncogenic capability was detected by apoptosis proliferation assays U87MG T98G cells. Immunohistochemistry determine IκBα tissues, luciferase reporter assay carried out...
Abstract Glioblastoma is the most common and aggressive primary brain tumor in adults. New drug design development still a major challenge for glioma treatment. Increasing evidence has shown that nitazoxanide, an antiprotozoal drug, novel antitumor role various tumors exhibits multiple molecular functions, especially autophagic regulation. However, whether nitazoxanide-associated autophagy antineoplastic effect remains unclear. Here, we aimed to explore underlying mechanism of nitazoxanide...
Daqu is used as the fermentation starter of Baijiu and contributes diversified functional microbes for saccharifying grains converting sugars into ethanol aroma components in products. mainly classified three types, namely low (LTD), medium (MTD) high (HTD) temperature Daqu, according to highest temperatures reached their processes. In this study, we PacBio small-molecule real-time (SMRT) sequencing technology determine full-length 16 S rRNA gene sequences from metagenomes 296 samples...
The tumor immune microenvironment is closely related to the malignant progression and treatment resistance of glioma. Long non-coding RNA (lncRNA) plays a regulatory role in this process. We investigated pathological mechanisms within glioma potential immunotherapy lncRNAs. downloaded datasets derived from patients analyzed them by hierarchical clustering. Next, we glioma, gene expression, patient survival. Coexpressed lncRNAs were generate model immune-related genes. using survival Cox...
Recent studies on population genomics of Saccharomyces cerevisiae have substantially improved our understanding the genetic diversity and domestication history yeast. However, origin domesticated S. genomic changes responsible for ecological adaption different populations lineages remain to be fully revealed. Here we sequenced 64 African strains from various indigenous fermented foods forests in countries performed a analysis them combined with set previously worldwide representing maximum...
Very little is known regarding correlation of micro RNA (miR)-106a with clinical outcomes patients glioblastoma multiforme (GBM). This study determined whether miR-106a could be used as an independent prognostic biomarker in those patients.A total 156 GBM were divided into 2 cohorts. In the first cohort, matched fresh frozen and formalin-fixed paraffin-embedded (FFPE) samples collected from 24 patients, while second only FFPE 132 patients. MiR-106a expression levels examined by quantitative...
Four yeast strains belonging to the ascomycetous genus Ascoidea were isolated from mixture of remnants steamed sorghum, Daqu powder and fermented grain that fell off during transportation on ground in workshop which collected Xinghuacun Fenjiu old workshop, Shanxi province, PR China. We propose name xinghuacunensis sp. nov. (holotype: strain CGMCC 2.7787) for new species, differs phenotypically other three species this genus: asiatica, rubescens tarda by its ability grow at 37 °C. This study...
Abstract Postoperative recurrence of glioblastoma (GBM) is a key contributing factor to the unfavorable prognosis patients. Chemotherapy has been extensively employed as postoperative treatment for GBM; however, produced drug resistance significantly undermines chemotherapeutic efficacy. Herein, multifunctional system based on magnesium micromotor (Mg‐Motor‐DOX) designed and fabricated that can generate hydrogen gas in situ actively deliver doxorubicin (DOX). Utilizing temperature‐sensitive...
Medium-temperature Daqu (MTD) serves as the saccharification and fermentation starter for Nongxiangxing Baijiu. Flipping (FD) during is a key craft in traditional MTD preparation. However, mechanism underlying this flipping remains unclear. To address this, we systematically compared FD with non-flipping (NFD) to elucidate microbial succession dynamics, metabolic phenotypes, environmental drivers. Our results demonstrated divergent community patterns between NFD stable phase (days 9-25)....
Abstract BACKGROUND As one of the origin centers domesticated plants in world, Ethiopia is rich diversified fermented foods and beverages, which yeasts are usually among essential functional microorganisms. This study aims to investigate yeast species diversity distribution indigenous products using conventional isolation molecular identification methods. RESULT Yeast cell counts 221 samples various Ethiopian traditional products, including staple foods, alcoholic dairy condiments, were...
Glioblastoma multiforme (GBM) is the most aggressive primary tumor of central nervous system. As biomedicine advances, researcher has found development GBM closely related to immunity. In this study, we evaluated immunoreactivity and defined Immune-High (IH) Immune-Low (IL) immunophenotypes using transcriptome data from 144 tumors profiled by The Cancer Genome Atlas (TCGA) project based on single-sample gene set enrichment analysis (ssGSEA) five immune expression signatures (IFN-γ response,...
Medium-temperature Daqu (MT-Daqu) serves as a crucial saccharifying and fermentation agent in the production of strong-flavor Baijiu. Due to spatial heterogeneity solid fermentation, significant differences occurred state appearance features different parts during fermentation. Currently, understanding underlying mechanism behind this phenomenon remains limited. Here, we analyzed microbial succession assembly models driving factors MT-Daqu at species level based on PacBio single-molecule...
Gliomas are the most common central nervous system tumors. They show malignant characteristics indicating rapid proliferation and a high invasive capacity associated with poor prognosis. In our previous study, p68 was overexpressed in glioma cells correlated both degree of differentiation overall survival. Downregulating significantly suppressed cells. Moreover, we found that gene promoted cell growth by activating nuclear factor-κB signaling pathway downstream molecular mechanism remains...
Yeasts are common inhabitants of most fruit trees' rhizospheres and phyllospheres. Wild yeasts the major driving force behind several modern industrial biotechnologies. This study focused on determining occurrence frequency wild associated with domestic edible tree barks, fruits, rhizosphere soil samples collected over two seasons (i.e., spring summer) in South West Ethiopia. A total 182 yeast strains were isolated from 120 samples. These belonged to 16 genera 27 species as identified based...
The present study reports a rare case of large capillary hemangioma the temporal bone with dural tail sign. A 57-year-old female presented pulsatile tinnitus and episodic vertigo associated ten-year history an intermittent faint headache. Magnetic resonance imaging revealed mass in right petrous bone, which was hypointense on T1-weighted images heterogeneously hyperintense T2-weighted images, showed sign following gadolinium administration. Pre-operatively, this tumor believed to be...