A5104652229- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Spine and Intervertebral Disc Pathology
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuroscience of respiration and sleep
- Cancer therapeutics and mechanisms
- Neurotransmitter Receptor Influence on Behavior
- RNA modifications and cancer
- Spinal Hematomas and Complications
- Nuts composition and effects
- Hearing, Cochlea, Tinnitus, Genetics
- Prenatal Substance Exposure Effects
- Ferroptosis and cancer prognosis
- Ultrasound and Hyperthermia Applications
- Medical Imaging and Analysis
- Biomarkers in Disease Mechanisms
- Vestibular and auditory disorders
- Animal Virus Infections Studies
- Nursing education and management
- Adenosine and Purinergic Signaling
Qingdao Mental Health Center
2023-2025
Yuhuangding Hospital
2012-2024
Qingdao University
2017-2024
First Affiliated Hospital of Xiamen University
2024
First Affiliated Hospital of Harbin Medical University
2013-2020
Harbin Medical University
2013-2020
Shandong University
2017
University of Chicago Medical Center
2013
NYU Langone Health
2013
Union Hospital
2012
Abstract Glioblastoma is the most common and aggressive primary brain tumor in adults. New drug design development still a major challenge for glioma treatment. Increasing evidence has shown that nitazoxanide, an antiprotozoal drug, novel antitumor role various tumors exhibits multiple molecular functions, especially autophagic regulation. However, whether nitazoxanide-associated autophagy antineoplastic effect remains unclear. Here, we aimed to explore underlying mechanism of nitazoxanide...
Abstract Background Hepatocellular carcinoma (HCC) has been recognized as a member of the most common human malignant tumors globally. According to multiple studies, long noncoding RNAs (lncRNAs) have defined vital regulators in tumor progression. Although previous studies indicated that lncRNA intergenic non‐protein coding RNA 467 (LINC00467) exerts oncogenic effect tumorigenesis and development cancers, specific function LINC00467 induces HCC remains obscure. Methods expression was...
Very little is known regarding correlation of micro RNA (miR)-106a with clinical outcomes patients glioblastoma multiforme (GBM). This study determined whether miR-106a could be used as an independent prognostic biomarker in those patients.A total 156 GBM were divided into 2 cohorts. In the first cohort, matched fresh frozen and formalin-fixed paraffin-embedded (FFPE) samples collected from 24 patients, while second only FFPE 132 patients. MiR-106a expression levels examined by quantitative...
Abstract Background At present, the treatment of recurrent glioblastoma is extremely challenging. In this study, we used a novel three-dimensional non-coplanar template (3DNPT) combined with open MR to guide 125 I seed implantation for glioblastoma. The aim study was evaluate feasibility, accuracy, and effectiveness technique. Methods Twenty-four patients underwent 3DNPT MR-guided brachytherapy from August 2017 January 2019. Preoperative plan were made according enhanced isovoxel T1-weighted...
Clusterin/apolipoprotein J (Clu) is a ubiquitously expressed secreted heterodimeric glycoprotein that implicated in several physiological processes. It has been reported the elevated level of clusterin (sClu) protein associated with poor survival breast cancer patients and can induce metastasis rodent models. In this study, we investigated effects sClu inhibition small interfering RNAs (siRNAs) on cell motility, invasion, growth vitro vivo. MDA-MB-231 cells were transfected...
<i>Aim: To study the feasibility and curative effect of</i><sup>125</sup><i>I seeds articles combined with biliary stent implantation in treatment of malignant obstructive jaundice. Patients Methods: Fifty patients jaundice were included. Twenty-four treated by intraluminal brachytherapy <sup>125</sup>I as experimental group, while remaining 26 only control group. The goal this was to evaluate total bilirubin, direct bilirubin tumor markers (cancer antigen (CA)-199, CA-242 carcinoembryonic...
Background/Aims: Kaiso (ZBTB33) expression is closely associated with the progression of many cancers and microRNA (miRNA) processing. MiR-181a plays critical roles in multiple cancers; however, its precise mechanisms glioma have not been well clarified. The goal this study was to evaluate interaction between miR-181a glioma. Methods: Quantitative real-time PCR (qRT-PCR) performed detect levels tissues cell lines. Cell proliferation, invasion, epithelial–mesenchymal transition (EMT) were...
The present study aimed to determine the role of arginase (Arg) in pulmonary arterial hypertension (PAH). In vitro, human artery smooth muscle cells (HPASMCs) were cultured under hypoxic conditions with, or without, Arg inhibitor, S‑(2‑boronoethyl)‑l‑cysteine (BEC), for 48 h, following which proliferation HPASMCs was determined using MTT and cell counting assays. For vivo investigation, 30 male rats randomly divided into three groups (n=10 per group): i) control group, ii) PAH group iii) BEC...
The depressor mechanism of imidazoline‐like drugs is believed to result from activation I 1 ‐imidazoline receptors (I R) and/or α 2 ‐adrenoceptors within the central nervous system, which are associated with glutamatergic system. rostral ventrolateral medulla (RVLM) has been recognized as a specific target area that mediates action drugs. objective this study was determine comparative effects blockade glutamate receptor subtypes N ‐methyl‐ d ‐aspartate (NMDA) or...
To prospectively estimate the safety, feasibility and accuracy of 1.0T open-magnetic resonance (MR)-guided percutaneous biopsy in free-hand focal lesions located hepatic dome.All MR-guided biopsies were performed at Shandong Medical Imaging Research Institute. Thirty-six patients with liver dome measuring 6-36 mm maximum diameter included this study. Lesions divided into two groups on basis nodule diameters: ≤1.5 cm (n=14) >1.5 (n=22). Surgical pathology nodules or clinical imaging follow-up...
Pancreatic carcinoma is a common cause of cancer deaths worldwide. Biopsy often required for the initial diagnosis pancreatic masses. can be performed endoscopically or percutaneously with computed tomography (CT) and ultrasound (US) guidance. MRI offers many inherent advantages over CT US.To prospectively evaluate feasibility, accuracy, safety MRI-guided percutaneous coaxial cutting needle biopsy lesions using an open 1.0T high-field MR scanner.Prospective.Thirty-one patients 31 underwent...
OBJECTIVE. The objective of our study was to prospectively evaluate the feasibility, safety, and effectiveness 1-T open MRI-guided percutaneous cryoablation hepatic dome hepatocellular carcinomas (HCCs). SUBJECTS AND METHODS. Thirty-seven patients with 37 HCCs underwent cryoablations. MR fluoroscopy a freehand technique applied in procedure. All lesions ranged size from 8 38 mm. Patients were followed for at least 12 months after or until death. Survival period, local tumor control,...
Abstract Background Tumors are the second most common cause of death in humans worldwide, only to cardiovascular and cerebrovascular diseases. Although methods techniques for treatment tumors continue improve, effect is not satisfactory. These may lack effective therapeutic targets. This study aimed evaluate value SNHG12 as a biomarker prognosis clinical characteristics various cancer patients. Methods We analyzed expression plotted survival curves all samples TCGA database using GEPIA tool....
LncRNAs exert comprehensive effects in regulating the initiation and deterioration of hepatocellular carcinoma (HCC). However, specific expression profiles functional mechanisms LINC00536 HCC need to be disclosed. The study is intended clarify leverage investigate potential for regulatory role progression HCC. In our study, was overexpressed tumor samples patients related poor prognosis. knockdown impaired cell viability, proliferation, migration, invasion. can directly bind with...
This study was aimed at evaluating the effectiveness and safety of percutaneous lateral lumbar discectomy (PLLD) in treating patients with lumber disc herniation.A total 183 herniation were recruited to receive PLLD surgery from April 2006 October 2011. All adverse effects recorded during follow-up 1, 3, 6, 12 months after PLLD. The clinical outcomes determined by visual analog scale Japanese Orthopaedic Association SCORE.The performed successfully all (102 males 81 females aged 21 66 years)...
Loss of skeletal muscle volume is an important aspect sarcopenia in hepatocellular carcinoma (HCC) patients treated by surgical resection, transcatheter arterial chemoembolization (TACE), or sorafenib.
Gonadal hormones have been shown that they may play a role in the perception of painful stimulations. P2X3 receptor has its involvement transduction peripheral pain as well. In this study, we conducted experiments to investigate effects gonadal ovary on expression rat dorsal root ganglion (DRG). The results real time PCR and immunohistochemisty showed higher levels mRNA increased numbers neurons DRG from OVX rats compared with sham-operated rats. Using patch clamp recording, also found...