A5101731126- Pharmacological Effects of Natural Compounds
- Psoriasis: Treatment and Pathogenesis
- Traditional Chinese Medicine Analysis
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Pharmacy and Medical Practices
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Advanced Drug Delivery Systems
- Plant-based Medicinal Research
- Retinoids in leukemia and cellular processes
- Computational Drug Discovery Methods
- Urticaria and Related Conditions
- Cytokine Signaling Pathways and Interactions
- Cancer Treatment and Pharmacology
- Antibiotics Pharmacokinetics and Efficacy
- Curcumin's Biomedical Applications
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Coal Properties and Utilization
- Biocrusts and Microbial Ecology
- Berberine and alkaloids research
- Asthma and respiratory diseases
- Medicinal Plant Pharmacodynamics Research
- Drug Transport and Resistance Mechanisms
Second Military Medical University
2010-2023
South China University of Technology
2022-2023
Changhai Hospital
2009-2022
Ningxia University
2021-2022
Zhangjiakou Academy of Agricultural Sciences
2022
Shenhua Group (China)
2021
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2019-2021
Harbin Engineering University
2008-2011
Shanghai Medical Information Center
2010
Shanghai East Hospital
2010
Curcumin, a selective phosphorylase kinase inhibitor, is naturally occurring phytochemical present in turmeric. Curcumin has been confirmed to have anti-inflammatory properties addition the ability decrease expression of pro-inflammatory cytokines keratinocytes. The interleukin-23 (IL-23)/IL-17A cytokine axis plays critical role pathogenesis psoriasis. Here, we report that topical use curcumin gel formulation strongly inhibited imiquimod (IMQ)-induced psoriasis-like inflammation, development...
The P. falciparum chimeric protein 2.9 (PfCP-2.9) consisting of the sequences MSP1-19 and AMA-1 (III) is a malaria vaccine candidate that was found to induce inhibitory antibodies in rabbits monkeys. This phase I randomized, single-blind, placebo-controlled, dose-escalation study evaluate safety immunogenicity PfCP-2.9 formulated with novel adjuvant Montanide ISA720. Fifty-two subjects were randomly assigned 4 dose groups 10 participants, each receiving test 20, 50, 100, or 200 microg...
Abstract Objectives The aim was to prepare neoglycoprotein-based nanoparticles for targeted drug delivery hepatic stellate cells, and evaluate their characteristics in vitro vivo. Methods neoglycoprotein of bovine serum albumin modified with mannose 6-phosphate synthesised from mannose, used as wall material nanoencapsulate the model natural antifibrotic substance sodium ferulate using a desolvation method. morphology, loading capacity, release biodistribution vivo were studied. Selectivity...
The interleukin-23/interleukin 17A (IL-23/IL-17A) cytokine axis plays a critical role in the pathogenesis of psoriasis. In this study, we report effects topical calcipotriol, camptothecin, clobetasol and tazarotene on treatment imiquimod (IMQ)-induced psoriasis-like inflammation, development which is dependent IL-23/IL-17A axis. IMQ-induced epidermal hyperplasia inflammation BALB/c mouse ear were significantly inhibited following but not camptothecin or treatments. Real-time polymerase chain...
An imiquimod (IMQ) induced wild type (WT) mouse can mimic some features of psoriasis, such as thickened skin, abnormal keratinocyte-related proteins, infiltration inflammatory cells and pro-inflammatory cytokines. This model is a prevalent that widely used in the study psoriasis. However, skin inflammation decreases during eighth day when IMQ given to WT mice, which may result false results evaluating pharmacodynamics effects drug. To extend timeliness inherit advantages this model, we...
Abstract Background Drought is an important abiotic stress that constrains the growth of many species. Despite extensive study in model organisms, underlying mechanisms drought tolerance Nostoc flagelliforme remain elusive. Results We characterized adaptation N. by a combination proteomics and qRT-PCR. A total 351 differentially expressed proteins involved were identified. It was found expression several nutrient influx transporters increased, including molybdate ABC transporter substrate...
Solid dispersions of silymarin were prepared by the fusion method with intention improving dissolution properties silymarin. Polyethylene glycol 6000 (PEG 6000) was used as inert hydrophilic matrix. The studies solid performed in vitro. And results obtained showed that rate considerably improved when formulated PEG compared to original drug, and increased might be favorable for further oral absorption.
Abstract Objectives Ginsenoside Rg1 (GRg1), one of the major active constituents Panax notoginseng, has shown anti-inflammatory and antinocioceptic activity, but its role in keratinocytes needs further study. We have examined inhibitory effect GRg1 on transient receptor potential vanilloid-1 (TRPV1) activation keratinocyte HaCaT cells explored involved mechanism. Methods HEK 293T over-expressing exogenous TRPV1 were constructed named 293T-TRPV1 cells. The effects production interleukin-8...
Nostoc flagelliforme is a kind of terrestrial edible cyanobacteria with important ecological and economic value which has developed special mechanisms to adapt drought conditions. However, the specific mechanism lipidome changes in tolerance N. not been well understood. In this study, ultra-high-performance liquid chromatography mass spectrometry were employed analyze under dehydration. A total 853 lipid molecules identified, 171 significantly different from that control group. The...
There is increasing evidence that epidermal carboxylesterase may be involved in the stereoselective hydrolysis of prodrugs percutaneous absorption. The present study was designed to evaluate characteristics and mechanisms ketoprofen ethyl ester by expressed HaCaT keratinocytes. Ketoprofen mainly hydrolyzed R-ketoprofen human Human carboxylesterase-1 (hCE-1) carboxylesterase-2 (hCE-2) were intensively detected L02 hepatocytes, hCE-2 also keratinocytes, but hCE-1 not thus an abundant...
Pulmonary fibrosis occurs due to fibroblast proliferation and collagen production in the lung begins with alveolar inflammatory edema. Aquaporins (AQPs) play pivotal roles fluid transport. In this study we establish experimental model for pulmonary C57BL/6 mice investigate expressions of AQP1 AQP5 tissue.Mice groups were treated intratracheally bleomycin dose 5 mg/kg body weight. The sacrificed at 1 week, 2 weeks 3 respectively. left upper lungs harvested histopathologic H-E Masson's...
It was previously reported that the expression of CD274 down-regulated in psoriatic epidermis, leading to immune disorders psoriasis. However, regulatory mechanisms were rarely elucidated. We aimed explore CD274. Skin samples collected from 18 patients with psoriasis vulgaris and 9 healthy participants for RNA sequencing. Candidate genes chosen based on degree k-core difference co-expression network. The relations between candidate validated by flow cytometry real-time PCR primary human...
Acetylation represents an extensively occurring protein post-translational modification (PTM) that plays a key role in many cellular physiological and biochemical processes. However, studies on PTMs such as acetylation of lysine (LysAc) cyanobacteria are still rare. In this study, quantitative LysAc approach (acetylome) the strains Nostoc flagelliforme subjected to different dehydration treatments was conducted. We observed starch contents were significantly accumulated due treatments, we...
Although numerous studies have tried to explain the mechanism of directional hydraulic fracturing in a coal seam, few them been conducted on gas migration stimulated by during mine methane extraction. In this study, fully coupled multi-scale model stimulate extraction from seam was developed and calculated finite element approach. The considers flow heat transfer within fractures, matrix, cleat system, it accounts for deformation. verified using amount data NO.8 at Fengchun mine, Chongqing,...