A5042625154- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Neonatal Respiratory Health Research
- Consumer Attitudes and Food Labeling
- Eating Disorders and Behaviors
- Biochemical Analysis and Sensing Techniques
- Assisted Reproductive Technology and Twin Pregnancy
- Culinary Culture and Tourism
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Prenatal Screening and Diagnostics
- Food composition and properties
- Cardiac electrophysiology and arrhythmias
- Maternal Mental Health During Pregnancy and Postpartum
- Regulation of Appetite and Obesity
- Education, Sociology, Communication Studies
- Cardiovascular Health and Disease Prevention
- Consumer Behavior in Brand Consumption and Identification
- Nutritional Studies and Diet
- Microbial Metabolism and Applications
- Fatty Acid Research and Health
- Infant Nutrition and Health
- Erythrocyte Function and Pathophysiology
University of Liverpool
2014-2024
Genomics (United Kingdom)
2015
University of Aberdeen
2015
University of Dundee
1997-1998
BackgroundSevere early-onset fetal growth restriction can lead to a range of adverse outcomes including or neonatal death, neurodisability, and lifelong risks the health affected child. Sildenafil, phosphodiesterase type 5 inhibitor, potentiates actions nitric oxide, which leads vasodilatation uterine vessels might improve in utero.MethodsWe did this superiority, placebo-controlled randomised trial 19 medicine units UK. We used random computer allocation (1:1) assign women with singleton...
(Abstracted from BJOG 2024;131:1673–1683) Fetal growth restriction (FGR) occurs when a fetus grows slower than expected for gestational age. Severe early-onset cases are associated with stillbirth, neonatal death, and developmental disorders.
To identify current practices in the management of selective fetal growth restriction (sFGR) monochorionic diamniotic (MCDA) twin pregnancies.
Acute and medium-term intervention studies suggest that non-nutritive sweeteners (NNS) are beneficial for weight loss, however there is limited human data on the long-term effects of consuming NNS maintenance, appetite. Further research therefore required to elucidate prolonged impact consumption these outcome measures. A randomized parallel groups design will be used assess whether regular beverage intake equivalent a water control in promoting loss over 12-weeks (weekly sessions; Phase I),...
ABSTRACT Objectives Fetal growth restriction (FGR) is associated with maternal cardiovascular changes. Sildenafil, a phosphodiesterase type‐5 inhibitor, potentiates the actions of nitric oxide, and it has been suggested that alters hemodynamics, potentially improving placental perfusion. Recently, Dutch STRIDER trial was stopped prematurely owing to excess neonatal mortality secondary pulmonary hypertension. The main aim this study investigate effect sildenafil on hemodynamics in pregnancies...
Selective fetal growth restriction (sFGR) in monochorionic twin pregnancy, defined as an estimated weight (EFW) of one <10th centile and EFW discordance ≥25%, is associated with stillbirth neurodisability for both twins. The condition poses unique management difficulties: on the hand, continuation pregnancy carries a risk death smaller twin, high co-twin demise (40%) or neurological sequelae (30%). On other, early delivery to prevent may expose larger prematurity, risks long-term physical,...
Abstract Background Stillbirth remains a major concern across the globe and in some high-resource countries, such as UK; efforts to reduce rate have achieved only modest reductions. One third of stillborn babies are small for gestational age (SGA), these pregnancies also at risk neonatal adverse outcomes lifelong health problems, especially when delivered preterm. Current UK clinical guidance advocates regular monitoring early term delivery SGA fetus; however, most appropriate regimen...
Abstract Introduction A 2018 Cochrane review found that omega‐3 supplementation in pregnancy was associated with a risk reduction of early preterm birth 0.58; prompting calls for universal supplementation. Recent analysis suggests the benefit may be confined to women low baseline fatty acid status. However, contemporary status pregnant UK is largely unknown. This particularly pertinent previous birth, whom small relative would have larger absolute risk. study aimed assess population and...
Summary SATIN , or SAT iety IN novation, is a 5‐year E uropean‐funded research project to develop and test new food products with satiating qualities help control appetite, manage weight combat obesity. It €6 million Framework 7 funded by the uropean C ommission, designed foods that regulate appetite reducing hunger, accelerating within‐meal satiation enhancing between meal satiety. The employs novel processing methods modify structure produce functional for management. This article provides...
Severe early-onset fetal growth restriction (FGR) causes stillbirth, neonatal death and neurodevelopmental impairment. Poor maternal spiral artery remodelling maintains vasoactive responsiveness but is susceptible to treatment with sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, which may improve perinatal outcomes.