A5033402106- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Acute Ischemic Stroke Management
- Spatial Neglect and Hemispheric Dysfunction
- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- Asthma and respiratory diseases
- Reading and Literacy Development
- Ophthalmology and Eye Disorders
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Urban Green Space and Health
- Obsessive-Compulsive Spectrum Disorders
- Hallucinations in medical conditions
- Humor Studies and Applications
- Mitochondrial Function and Pathology
- Neurological Disorders and Treatments
- Vestibular and auditory disorders
- Neonatal and fetal brain pathology
Leipzig University
2016-2025
University Medical Center
2022
University Hospital Leipzig
2015-2022
University Hospital in Halle
2022
Ludwig-Maximilians-Universität München
2015-2021
Klinik und Poliklinik für Neurologie
2015-2016
Abstract The loss and recovery of language functions are still incompletely understood. This longitudinal functional MRI study investigated the neural mechanisms underlying in patients with post-stroke aphasia putting particular emphasis on impact lesion site. To identify patterns language-related activation, an auditory sentence comprehension paradigm was administered to circumscribed lesions either left frontal (n = 17) or temporo-parietal cortex. Patients were examined repeatedly during...
Diaschisis is a phenomenon observed in stroke that defined as neuronal dysfunction regions spared by the infarction but connected to lesion site. We combined network mapping and task-based functional MRI 71 patients with post-stroke aphasia investigate, whether diaschisis its resolution contribute early loss recovery of language functions. Language activation acquired acute, subacute chronic phase was analyzed compartments high low normative resting-state connectivity site on an individual...
Genomewide association studies identified ORMDL3 as a plausible asthma candidate gene. ORMDL proteins regulate sphingolipid metabolism and ceramide homeostasis participate in lymphocyte activation eosinophil recruitment. Strong sequence homology between the three genes protein conservation among different species suggest that they may have shared functions. We hypothesized if single nucleotide polymorphisms (SNPs) alter its gene expression play role asthma, variants ORMDL1 ORMDL2 might also...
Introduction Post-stroke depressive symptoms (PSDS) are common and relevant for patient outcome, but their complex pathophysiology is ill understood. It likely involves social, psychological biological factors. Lesion location a readily available information in stroke patients, it unclear if the neurobiological substrates of PSDS spatially localized. Building on previous analyses, we sought to determine associated with specific lesion locations, structural disconnection and/or localized...
Abstract Transcranial magnetic stimulation (TMS) and deep brain (DBS) can treat some neuropsychiatric disorders, but there is no consensus approach for identifying new targets. We localized causal circuit-based targets anxiety that converged across multiple natural experiments. Lesions (n=451) TMS sites (n=111) modify mapped to a common normative circuit (r=0.68, p=0.01). In an independent dataset (n=300), individualized site connectivity this predicted change (p=0.02). Subthalamic DBS...
A new functional deficit caused by a stroke can be understood as situation of uncertainty that has to prompt discovery and subsequent incorporation into an altered self-perception. Anosognosia for visual field deficits is frequent after stroke. For hemiplegia, patients' performance in riddle test provided evidence the inability generate adjust beliefs face contributes anosognosia hemiplegia. In this prospective study, same riddles are used patients with homonymous hemianopia due first-ever...
Abstract The advent of endovascular thrombectomy has significantly improved outcomes for stroke patients with intracranial large vessel occlusion, yet individual benefits can vary widely. As demand rises and geographic disparities in care access persist, there is a growing need predictive models that quantify benefits. However, current imaging methods estimating may not fully capture the dynamic nature cerebral ischemia lack patient-specific assessment Our study introduces deep learning...
Language is sustained by large-scale networks in the human brain. Stroke often severely affects function and network dynamics. However, adaptive potential of brain to compensate for lesions poorly understood. A key question whether upregulation right hemisphere language recovery. Targeting short-term reorganization lesioned brain, we applied 'virtual lesions' over left anterior or posterior inferior frontal gyrus (IFG) post-stroke patients with temporo-parietal prior functional neuroimaging....
Anosognosia for hemiplegia (AHP) is known to be associated with lesions the motor system combined varying right insula, premotor cortex, parietal lobe or hippocampus. Due this widespread cortical lesion distribution, AHP can understood best as a network disorder. We used maps and behavioral data (n = 49) from two previous studies on performed network-symptom-mapping (LNSM) analysis. This new approach permits identification of relationships between behavior regions connected site based...
Theories assume that thalamic stroke may cause aphasia because of dysfunction in connected cortical networks. This takes into account brain functions are organized distributed networks, and turn, localized damage result a network disorder such as aphasia. With this study, we investigate whether the integration thalamus specific thalamocortical networks underlies symptoms after stroke. We hypothesize lesions patients with language impairments functionally to for cognition.We combined...
The presence of both isolated thalamic and cortical lesions have been reported in the context pusher syndrome-a disorder characterized by a disturbed perception one's own upright body posture, following unilateral left- or right-sided stroke. In recent times, indirect quantification functional structural disconnection increases knowledge derived from focal brain inferring subsequent network damage respective lesion. We applied measures to sample 124 stroke patients investigate syndrome. Our...
Language impairments after thalamic lesions, referred to as aphasia, underscore a subcortical involvement in language processing. In this study, we investigated how the thalamus structurally connects cortex support functions. Our hypothesis posits that disconnection of white matter tracts between left and regions hemisphere cognitive control networks, such prefrontal, inferior frontal, temporal cortices, are associated with aphasia. We employed non-parametric lesion-network mapping approach...
Voxelwise disconnection mapping is a novel approach to disclose lesion-symptom relationships for symptoms caused by white matter disconnection. It uses MRI-based fiber tracking in healthy subjects seeded from patient's focal brain lesions. Resulting individual maps can then be statistically associated with symptoms. Despite increasing use the recent years, validity of this remains investigated. In study, we validated both, our own implementation and provided within BCBtoolkit. For technical...
Abstract Background and Objectives Spatial neglect is commonly attributed to lesions of a predominantly right-hemispheric cortical network. Although spatial was also repeatedly observed after the basal ganglia thalamus, many anatomical network models omit these structures. We investigated if disruption functional or structural connectivity can explain in subcortical stroke. Methods retrospectively data first-ever, acute stroke patients with right-sided (n = 27) thalamus 16). Based on lesion...
Depressive symptoms are a common stroke sequela, yet their neurobiological substrates still unclear. We sought to determine if they associated with specific lesion locations.In prospective observational study, 270 patients were tested twice the Hospital Anxiety and Depression Scale around day 6 again months poststroke voxel-based behavior mapping was performed.Frequency of depressive (depression subscale >7) after 19.6 %. Higher scores for depression only variable in multiple logistic...
Semantic cognition, i.e. processing of meaning is based on semantic representations and their controlled retrieval. control has been shown to be implemented in a network that consists left inferior frontal (IFG), anterior posterior middle temporal gyri (a/pMTG). We aimed disrupt processes with continuous theta burst stimulation (cTBS) over IFG pMTG study whether behavioral effects are moderated by induced alterations resting-state functional connectivity. To this end, we applied real cTBS as...
Poststroke depression is a common stroke sequel, yet its neurobiological substrates are still unclear. We sought to determine whether specific lesion locations associated with depressive symptoms after stroke.In prospective study, 270 patients first ever were repeatedly tested the subscale of Hospital Anxiety and Depression Scale within 4 weeks 6 months stroke. Voxel-based behavior mapping based on clinical imaging was performed test for associations between locations.Frequency poststroke...
Modifiable risk factors play an important role in preventing dementia and reducing its progression. Regular physical activity already midlife, which relies on intact multisensory balance control, can help to decrease the of dementia. However, our understanding relationship between postural cognitive functions remains limited. The objective study was investigate association during different sensory conditions with specific domains older adults.
Abstract Perfusion CT is established to aid selection of patients with proximal intracranial vessel occlusion for thrombectomy in the extended time window. Selection mostly based on simple thresholding perfusion parameter maps, which, however, does not exploit full information hidden high-dimensional data. We implemented a multiparametric mass-univariate logistic model predict tissue outcome data from 405 stroke acute anterior circulation who underwent mechanical thrombectomy. Input...
Several mechanisms have been attributed to post-stroke loss and recovery of language functions. However, the significance timing domain-general homotopic right-hemispheric activation is controversial. We aimed examine effect left-hemispheric lesion location time on activation. Voxel-based analyses were informed by auditory language-related fMRI 71 patients with left middle cerebral artery stroke examined longitudinally in acute, subacute early chronic phase. Language was determined several...