A5100670337- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Developmental Biology and Gene Regulation
- Single-cell and spatial transcriptomics
- Helicobacter pylori-related gastroenterology studies
- Bacterial Identification and Susceptibility Testing
- Ferroptosis and cancer prognosis
- Fungal and yeast genetics research
- Neurogenesis and neuroplasticity mechanisms
- Phytochemical compounds biological activities
- Diphtheria, Corynebacterium, and Tetanus
- Microbial Metabolic Engineering and Bioproduction
- Cytokine Signaling Pathways and Interactions
- Endodontics and Root Canal Treatments
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Biofuel production and bioconversion
- Ginseng Biological Effects and Applications
- Infective Endocarditis Diagnosis and Management
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- RNA and protein synthesis mechanisms
- Bioinformatics and Genomic Networks
- Mesenchymal stem cell research
- Dermatology and Skin Diseases
Anhui Medical University
2024
Kingmed Diagnostics
2024
Guangzhou Medical University
2024
Nanjing University of Chinese Medicine
2023-2024
Stanford University
2022
Center for Excellence in Molecular Cell Science
2017-2020
Chinese Academy of Sciences
2017-2020
Tianjin University of Science and Technology
2020
Shanghai Institute of Nutrition and Health
2019-2020
Nanjing Agricultural University
2020
Abstract Motivation Gene set enrichment analysis (GSEA) is a commonly used algorithm for characterizing gene expression changes. However, the currently available tools to perform GSEA have limited ability analyze large datasets, which particularly problematic of single-cell data. To overcome this limitation, we developed package in Python (GSEApy), could efficiently datasets. Results We present (GSEApy) that performs either command line or environment. GSEApy uses Rust implementation enable...
Abstract In land plants, cytidine‐to‐uridine (C‐to‐U) editing of organellar transcripts is an important post‐transcriptional process, which considered to remediate DNA genetic mutations restore the coding functional proteins. Pentatricopeptide repeat (PPR) proteins have key roles in C‐to‐U editing. Owing its large number, however, biological functions many PPR remain be identified. Through characterizing a small kernel4 ( smk4 ) mutant, here we report function Smk4 and role maize growth...
Determining the source of infection is significant for treatment bloodstream infections (BSI). The gold standard blood detection, cultures, have low positive rates to meet clinical needs. In this study, we investigated ability hybrid capture-based next generation sequencing technology detect pathogens in peripheral samples collected from patients with suspected BSI. Blood cultures and capture assays were also analyzed against final diagnoses.
The generation of brain region-specific progenitors from human embryonic stem cells (hESCs) is critical for their application. However, transcriptional regulation neural regionalization in humans poorly understood. Here, we applied a rostrocaudal patterning system hESCs to dissect global networks controlling early regionalization. We found that SOX21 required rostral forebrain fate specification. knockout led activation Wnt signaling, resulting caudalization regional identity progenitor...
Inflammation often causes irreversible damage to dental pulp tissue. Dental stem cells (DPSCs), which have multidirectional differentiation ability, play critical roles in the repair and regeneration of However, presence proinflammatory factors can affect DPSCs proliferation, differentiation, migration, other functions. LL-37 is a natural cationic polypeptide that inhibits lipopolysaccharide (LPS) activity, enhances cytokine production, promotes migration cells. potential regenerative...
Two new C13-norsesquiterpenes claulanterpene A (1) and B (2), together with two known sesquiterpenes (3-4), were isolated from methanol extract of the stem leaf Clausena lansium collected Qingyuan county, Guangdong Province, China. Their structures elucidated on base extensive spectroscopic analysis comparison data reported in literature. Among them, compound 4 showed antibacterial activity against Bacillus cereus.
Region-specific neural progenitor cells (NPCs) can be generated from human embryonic stem (hESCs) by modulating signaling pathways. However, how intrinsic transcriptional factors contribute to the regionalization is not well characterized. Here, we generate region-specific NPCs hESCs and find that SOX1 highly expressed in with rostral hindbrain identity. Moreover, OTX2 inhibits expression, displaying exclusive expression between two factors. Furthermore, knockout (KO) leads upregulation of...
Avian pathogenic Escherichia coli (APEC), an extraintestinal E. (ExPEC), is the causative agent of avian colibacillosis, a disease that causes huge economic losses in poultry industry and characterized by infection through respiratory tract colonization followed bacteraemia. A previous study our lab demonstrated phiv142-3 enhanced survival ability APEC strain DE142 chickens serum. However, mechanism this affect has not been completely revealed. Here, we analyzed transcriptional level...
Background: Reproductive endocrine disorder can impair endometrial receptivity, preventing embryo implantation and increasing miscarriage risk. Impaired receptivity contributes significantly to female infertility. Inflammatory signaling pathways including the IL-6/STAT3 pathway help embryos implant. Therefore, it is crucial explore relationship between receptivity. Objective: To investigate mechanism by which Bushen Zhuyun decoction (BSZY) enhances in rats through pathway. Methods:...
Abstract Signaling pathways transmit extracellular cues into cells and regulate transcriptome epigenome to maintain or change the cell identity. Protein kinases phosphatases are critical for signaling transduction regulation. Here, we report that CDK11, a member of CDK family, is required maintenance human embryonic stem (hESC) self‐renewal. Our results show that, among three main isoforms CDK11 p46 isoform safeguarding hESC Mechanistically, constrains two important mitogen‐activated protein...
<div>Abstract<p>MPHOSPH1 is a critical kinesin protein that functions in cytokinesis. Here, we show MPHOSPH1 overexpressed hepatocellular carcinoma (HCC) cells, where it essential for proliferation. Attenuating expression with tumor-selective shRNA-expressing adenovirus (Ad-shMPP1) was sufficient to arrest HCC cell proliferation manner associated an accumulation of multinucleated polyploid induction postmitotic apoptosis, and increased sensitivity taxol cytotoxicity. Mechanistic...